Insights into the role of post-transcriptional processes in the influenza A virus life cycle
Influenza A viruses (IAV) infect and spread among people every winter, and are also the primary agent of every flu pandemic over the last 100 years. The EU-funded PTFLU project will focus on an understudied aspect of the IAV life cycle, the post-transcriptional regulation of IAV RNA. Research over the years has provided significant knowledge about the post-transcriptional regulation of cellular mRNAs. PTFLU wishes to extend these findings in IAV by identifying the locations of various RNA modifications present in both human and avian IAVs and studying their impact on RNA characteristics. Combined with insights into the ribosomal machinery implicated in IAV mRNA translation, this information will unveil important aspects of IAV biology and life cycle.
Fields of science
Call for proposal
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