Illuminating the role of transcription factor dynamics in development

Project description

Real-time imaging of transcription in living animals

Gene expression regulation is paramount for all biological processes including development. However, the role of genomic regulatory elements such as enhancers in time remains an open question. The EU-funded TF-Dynamics project proposes to study transcriptional regulation in living animals. For this purpose, scientists will use Drosophila as a model as well as imaging approaches that allow the visualisation of transcription factor concentration dynamics. This cutting-edge technology will help image individual protein–protein interactions with temporospatial resolution and determine how they drive transcription. Moreover, they will delineate the role of enhancer sequences in gene expression regulation.

Fields of science

Host institution

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Net EU contribution

€ 1 330 400,00

Address

Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Netherlands

Region

West-Nederland Noord-Holland Groot-Amsterdam

Activity type

Other

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 0,00

Beneficiaries (1)