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Illuminating the role of transcription factor dynamics in development

Project description

Real-time imaging of transcription in living animals

Gene expression regulation is paramount for all biological processes including development. However, the role of genomic regulatory elements such as enhancers in time remains an open question. The EU-funded TF-Dynamics project proposes to study transcriptional regulation in living animals. For this purpose, scientists will use Drosophila as a model as well as imaging approaches that allow the visualisation of transcription factor concentration dynamics. This cutting-edge technology will help image individual protein–protein interactions with temporospatial resolution and determine how they drive transcription. Moreover, they will delineate the role of enhancer sequences in gene expression regulation.

Host institution

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Net EU contribution
€ 1 330 400,00
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
€ 0,00

Beneficiaries (1)

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
Net EU contribution
€ 1 330 400,00
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
€ 0,00