Volumetric light-driven bioprinting capturing complex physiological shape, size and function in artificial tissues and organoids

Información del proyecto

VOLUME-BIO

Identificador del acuerdo de subvención: 949806

DOI

10.3030/949806

Fecha de la firma de la CE 6 Noviembre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 870 250,00

Aportación de la UE

€ 1 870 250,00

Coordinado por

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (25)

The road ahead in materials and technologies for volumetric 3D printing

Autores: Paulina Nunez Bernal, Sammy Florczak, Sebastian Inacker, Xiao Kuang, Jorge Madrid-Wolff, Martin Regehly, Stefan Hecht, Yu Shrike Zhang, Christophe Moser, Riccardo Levato
Publicado en: Nature Reviews Materials, 2025, ISSN 2058-8437
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41578-025-00785-3

Biofabricating the vascular tree in engineered bone tissue

Autores: Leanne de Silva, Paulina Nunez Bernal, Antoine Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Publicado en: Acta Biomaterialia, 2022, Página(s) 250/268, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2022.08.051

Acceleration of Bone Regeneration Induced by a Soft-Callus Mimetic Material

Autores: Alessia Longoni, Lizette Utomo, Abbie Robinson, Riccardo Levato, Antoine J. W. P. Rosenberg, Debby Gawlitta
Publicado en: Advanced Science, Edición 2103284, 2021, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202103284

Light-based vat-polymerization bioprinting

Autores: Riccardo Levato, Oksana Dudaryeva, Carlo Ezio Garciamendez-Mijares, Bruce Kirkpatrick, Riccardo Rizzo, Jacob Schimelman, Kristi Anseth, Shaochen Chen, Marcy Zenobi-Wong, Yu Shrike Zhang
Publicado en: Nature Reviews Methods Primers, 2023, ISSN 2662-8449
Editor: Springer Nature
DOI: 10.1038/s43586-023-00231-0

Biofunctionalization of 3D printed collagen with bevacizumab-loaded microparticles targeting pathological angiogenesis

Autores: Anna Abbadessa, Paulina Nunez Bernal, Giorgio Buttitta, Alfredo Ronca, Ugo D'Amora, Carla Zihlmann, Niklaus Stiefel, Luigi Ambrosio, Jos Malda, Riccardo Levato, Jose Crecente-Campo, Maria Jose Alonso
Publicado en: Journal of Controlled Release, Edición Volume 360, 2023, Página(s) 747-758, ISSN 1873-4995
Editor: Elsevier
DOI: 10.1016/j.jconrel.2023.07.017

Non-neotissue constituents as underestimated confounders in the assessment of tissue engineered constructs by near-infrared spectroscopy

Autores: Omar Elkadi, Florencia Abinzano, Ervi Nippolainen, Ona Bach Gonzalez, Riccardo Levato, Jos Malda, Isaac Afara
Publicado en: Materials Today Bio, Edición 24, 2023, Página(s) 100879, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2023.100879

Multi‐material Volumetric Bioprinting and Plug‐and‐play Suspension Bath Biofabrication via Bioresin Molecular Weight Tuning and via Multiwavelength Alignment Optics

Autores: Davide Ribezzi, Jan‐Philip Zegwaart, Thomas Van Gansbeke, Aitor Tejo‐Otero, Sammy Florczak, Joska Aerts, Paul Delrot, Andreas Hierholzer, Martin Fussenegger, Jos Malda, Jos Olijve, Riccardo Levato
Publicado en: Advanced Materials, Edición 37, 2025, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202409355

Bioprinting of Human Liver-Derived Epithelial Organoids for Toxicity Studies

Autores: Manon C. Bouwmeester, Paulina Nunez Bernal, Loes A. Oosterhoff, Monique E. van Wolferen, Vivian Lehmann, Monique Vermaas, Maj-Britt Buchholz, Quentin C. Peiffer, Jos Malda, Luc J. W. van der Laan, Nynke I. Kramer, Kerstin Schneeberger, Riccardo Levato, Bart Spee
Publicado en: Macromolecular Bioscience, 2021, ISSN 1616-5195
Editor: Wiley
DOI: 10.1002/mabi.202100327

A review of materials used in tomographic volumetric additive manufacturing

Autores: Jorge Madrid-Wolff; Joseph Toombs; Riccardo Rizzo; Paulina Nunez Bernal; Dominique Porcincula; Rebecca Walton; Bin Wang; Frederik Kotz-Helmer; Yi Yang; David Kaplan; Yu Shrike Zhang; Marcy Zenobi-Wong; Robert McLeod; Bastian Rapp; Johanna Schwartz; Maxim Shusteff; Hayden Taylor; Riccardo Levato; Christophe Moser
Publicado en: MRS Communications, 2023, ISSN 2159-6867
Editor: Springer
DOI: 10.1557/s43579-023-00447-x

Hybrid Plasmonic Bioresins and dECM-Based Materials for Volumetric Bioprinting of Vascular-Inspired Architectures

Autores: Uxue Aizarna-Lopetegui, Gabriel Größbacher, Ada Herrero-Ruiz, Aitor Tejo-Otero, Malou Henriksen-Lacey, Riccardo Levato, Dorleta Jimenez de Aberasturi
Publicado en: ACS Applied Materials & Interfaces, Edición 17, 2025, Página(s) 36982-36991, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.5c03880

Volumetric Printing across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics

Autores: Gabriel Größbacher, Michael Bartolf-Kopp, Csaba Gergely, Paulina Núñez Bernal, Sammy Florczak, Mylène de Ruijter, Núria Ginés Rodriguez, Jürgen Groll, Jos Malda, Tomasz Jüngst, Riccardo Levato
Publicado en: Advanced Materials, 2023, ISSN 1521-4095
Editor: Wiley
DOI: 10.1002/adma.202300756

Shaping Synthetic Multicellular and Complex Multimaterial Tissues via Embedded Extrusion-Volumetric Printing of Microgels

Autores: Davide Ribezzi, MArieme Gueye, Sammy Florczak, Franziska Dusi, Dieuwke de Vos, Francesca Manente, Andreas Hierholzer, Martin Fussenegger, Massimiliano Caiazzo, Torsten Blunk, Jos Malda, Riccardo Levato
Publicado en: Advanced Materials, 2023, ISSN 1521-4095
Editor: Wiley
DOI: 10.1002/adma.202301673

Progenitor Cells in Healthy and Osteoarthritic Human Cartilage Have Extensive Culture Expansion Capacity while Retaining Chondrogenic Properties.

Autores: Rikkers, M; Korpershoek, J V; Levato, R; Malda, J; Vonk, L A; Equine Musculoskeletal Biology; dES RMSC; Afd methoden en statistieken
Publicado en: Cartilage, 2021, ISSN 1947-6043
Editor: Sage
DOI: 10.1177/19476035211059600

High-resolution lithographic biofabrication of hydrogels with complex microchannels from low-temperature-soluble gelatin bioresins

Autores: Riccardo Levato, Khoon S. Lim, Wanlu Li, Ane Urigoitia Asua, Laura Blanco Peña, Mian Wang, Marc Falandt, Paulina Nuñez Bernal, Debby Gawlitta, Yu Shrike Zhang, Tim B.F. Woodfield, Jos Malda
Publicado en: Materials Today Bio, Edición 12, 2021, Página(s) 100162, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2021.100162

Development of a bioreactor and volumetric bioprinting protocol to enable perfused culture of biofabricated human epithelial mammary ducts and endothelial constructs

Autores: Maj-Britt Buchholz, Paulina Nunez Bernal, Nils Bessler, Camille Bonhomme, Riccardo Levato, Anne Rios
Publicado en: Biofabrication, Edición 17, 2025, Página(s) 031001, ISSN 1758-5082
Editor: IOS Press
DOI: 10.1088/1758-5090/add20f

Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges

Autores: Tommaso Zandrini, Sammy Florczak, Riccardo Levato, Aleksandr Ovsianikov
Publicado en: Trends in Biotechnology, 2022, ISSN 1879-3096
Editor: Cell Press
DOI: 10.1016/j.tibtech.2022.10.009

Non-destructive assessment of tissue engineered cartilage maturity using visible and near infrared spectroscopy combined with machine learning

Autores: Omar Anwar Elkadi, Florencia Abinzano, Ervin Nippolainen, Ona Bach González, Juha Töyräs, Riccardo Levato, Jos Malda, Isaac O. Afara
Publicado en: Biosensors and Bioelectronics, Edición 286, 2025, Página(s) 117587, ISSN 0956-5663
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2025.117587

Towards single-cell bioprinting: micropatterning tools for organ-on-chip development

Autores: Cecile Bosmans, Nuria Rodriguez, Marcel Karperien, Jos Malda, Liliana Moreira Teixeira, Riccardo Levato, Jeroen Leijten
Publicado en: Trends in Biotechnology, 2024, ISSN 1879-3096
Editor: Cell Press, Elsevier
DOI: 10.1016/j.tibtech.2023.11.014

In-Depth Investigation of Electrostatic Interaction-Based Hydrogel Shrinking for Volumetric Printing and Tissue Engineering Applications

Autores: Dmitrii Iudin, Léon J. J. A. Gerridzen, Paulina N. Bernal, Carl C. L. Schuurmans, Myriam Neumann, Lam Nguyen, Mies J. van Steenbergen, Jaimie Hak, Wanlu Li, Cristina Casadidio, Anne Metje van Genderen, Rosalinde Masereeuw, Riccardo Levato, Yu Shrike Zhang, Bas G. P. van Ravensteijn, Tina Vermonden
Publicado en: Biomacromolecules, Edición 26, 2025, Página(s) 4108-4123, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.5c00117

Human breast tissue engineering in health and disease

Autores: Maj-Britt Buchholz, Demi I Scheerman, Riccardo Levato, Ellen J Wehrens, Anne C Rios
Publicado en: EMBO Molecular Medicine, Edición 16, 2024, Página(s) 2299-2321, ISSN 1757-4684
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00112-3

Bioink with cartilage-derived extracellular matrix microfibers enables spatial control of vascular capillary formation in bioprinted constructs

Autores: Margo L Terpstra; Jinyu Li; Anneloes Mensinga; Mylène de Ruijter; Mattie H P van Rijen; Charalampos Androulidakis; Costas Galiotis; Ioannis Papantoniou; Michiya Matsusaki; Jos Malda; Riccardo Levato
Publicado en: Biofabrication, 2022, ISSN 1758-5090
Editor: Biofabrication
DOI: 10.1088/1758-5090/ac6282

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories

Autores: Paulina Nunez Bernal, Manon Bouwmeester, Jorge Madrid-Wolff, Marc Falandt, Sammy Florczak, Nuria Gines Rodriguez, Yang Li, Gabriel Groessbacher, Ros-Anne Samsom, Monique van Wolferenc, Luc J.W. van der Laan, Paul Delrot, Damien Loterie, Jos Malda, Christophe Moser, Bart Spee, Riccardo Levato
Publicado en: Advanced Materials, 2022, ISSN 1521-4095
Editor: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/adma.202110054

Spatial-Selective Volumetric 4D Printing and Single-Photon Grafting of Biomolecules within Centimeter-Scale Hydrogels via Tomographic Manufacturing

Autores: Marc Falandt; Paulina Bernal; Oksana Dudaryeva; Sammy Florczak; Gabriel Groessbacher; Matthias Schweiger; Alessia Longoni; Coralie Greant; Marisa Assuncao; Olaf Nijssen; Sandra van Vlierberghe; Jos Malda; Tina Vermonden; Riccardo Levato
Publicado en: Advanced Materials Technologies, 2023, ISSN 2365-709X
Editor: Wiley
DOI: 10.1002/admt.202300026

Programming Delayed Dissolution Into Sacrificial BioinksFor Dynamic Temporal Control of Architecture within3D-Bioprinted Constructs

Autores: Bram Soliman, Alessia Longoni, Mian Wang, Paulina Nunez Bernal, Alessandro Cianciosi, Gabriella Lindberg, Jos Malda, Juergen Groll, Tomasz Jungst, Riccardo Levato, Jelena Rnjak-Kovacina, Tim Woodfield, Yu Shrike Zhang, Khoon Lim
Publicado en: Advanced Functional Materials, 2023, ISSN 1616-3028
Editor: Wiley
DOI: 10.1002/adfm.202210521

Bioprinting and synthetic biology approaches to engineer functional endocrine pancreatic constructs

Autores: Davide Ribezzi, Pere Català, Cataldo Pignatelli, Antonio Citro, Riccardo Levato
Publicado en: Trends in Biotechnology, 2025, ISSN 0167-7799
Editor: Elsevier BV
DOI: 10.1016/j.tibtech.2025.03.005

Thesis and dissertations (1)

Crafting Tissue Complexity

Autores: null null, Paulina Núñez Bernal
Publicado en: 2024
Editor: Utrecht University Library
DOI: 10.33540/2116

Derechos de propiedad intelectual

Other (3)

HYBRID SUPRAMOLECULAR BIOMATERIAL FOR BIOPRINTING AND CELL CULTURE

Número de solicitud/publicación: PCT/EP 2023/073303
Fecha: 2023-08-24
Solicitante(s): UNIVERSITAIR MEDISCH CENTRUM UTRECHT

HYBRID SUPRAMOLECULAR BIOMATERIAL FOR BIOPRINTING AND CELL CULTURE

Número de solicitud/publicación: PCT/EP 2023/073303
Fecha: 2023-08-24
Solicitante(s): UNIVERSITEIT UTRECHT

USE OF GELATIN IN A SUPPORT MATERIAL FOR EMBEDDED PRINTING

Número de solicitud/publicación: PCT/EP 2024/060818
Fecha: 2023-04-21
Solicitante(s): UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Patent (1)

SYSTEM AND METHOD FOR GENERATING A THREE-DIMENSIONAL STRUCTURE WITHIN A VOLUME OF CURABLE MATERIAL

Número de solicitud/publicación: 20 24050642
Fecha: 2024-11-29
Solicitante(s): UNIVERSITAIR MEDISCH CENTRUM UTRECHT