Volumetric light-driven bioprinting capturing complex physiological shape, size and function in artificial tissues and organoids

Informazioni relative al progetto

VOLUME-BIO

ID dell’accordo di sovvenzione: 949806

DOI

10.3030/949806

Data della firma CE 6 Novembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Dicembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 870 250,00

Contributo UE

€ 1 870 250,00

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (25)

The road ahead in materials and technologies for volumetric 3D printing

Autori: Paulina Nunez Bernal, Sammy Florczak, Sebastian Inacker, Xiao Kuang, Jorge Madrid-Wolff, Martin Regehly, Stefan Hecht, Yu Shrike Zhang, Christophe Moser, Riccardo Levato
Pubblicato in: Nature Reviews Materials, 2025, ISSN 2058-8437
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41578-025-00785-3

Biofabricating the vascular tree in engineered bone tissue

Autori: Leanne de Silva, Paulina Nunez Bernal, Antoine Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Pubblicato in: Acta Biomaterialia, 2022, Pagina/e 250/268, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2022.08.051

Acceleration of Bone Regeneration Induced by a Soft-Callus Mimetic Material

Autori: Alessia Longoni, Lizette Utomo, Abbie Robinson, Riccardo Levato, Antoine J. W. P. Rosenberg, Debby Gawlitta
Pubblicato in: Advanced Science, Numero 2103284, 2021, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202103284

Light-based vat-polymerization bioprinting

Autori: Riccardo Levato, Oksana Dudaryeva, Carlo Ezio Garciamendez-Mijares, Bruce Kirkpatrick, Riccardo Rizzo, Jacob Schimelman, Kristi Anseth, Shaochen Chen, Marcy Zenobi-Wong, Yu Shrike Zhang
Pubblicato in: Nature Reviews Methods Primers, 2023, ISSN 2662-8449
Editore: Springer Nature
DOI: 10.1038/s43586-023-00231-0

Biofunctionalization of 3D printed collagen with bevacizumab-loaded microparticles targeting pathological angiogenesis

Autori: Anna Abbadessa, Paulina Nunez Bernal, Giorgio Buttitta, Alfredo Ronca, Ugo D'Amora, Carla Zihlmann, Niklaus Stiefel, Luigi Ambrosio, Jos Malda, Riccardo Levato, Jose Crecente-Campo, Maria Jose Alonso
Pubblicato in: Journal of Controlled Release, Numero Volume 360, 2023, Pagina/e 747-758, ISSN 1873-4995
Editore: Elsevier
DOI: 10.1016/j.jconrel.2023.07.017

Non-neotissue constituents as underestimated confounders in the assessment of tissue engineered constructs by near-infrared spectroscopy

Autori: Omar Elkadi, Florencia Abinzano, Ervi Nippolainen, Ona Bach Gonzalez, Riccardo Levato, Jos Malda, Isaac Afara
Pubblicato in: Materials Today Bio, Numero 24, 2023, Pagina/e 100879, ISSN 2590-0064
Editore: Elsevier
DOI: 10.1016/j.mtbio.2023.100879

Multi‐material Volumetric Bioprinting and Plug‐and‐play Suspension Bath Biofabrication via Bioresin Molecular Weight Tuning and via Multiwavelength Alignment Optics

Autori: Davide Ribezzi, Jan‐Philip Zegwaart, Thomas Van Gansbeke, Aitor Tejo‐Otero, Sammy Florczak, Joska Aerts, Paul Delrot, Andreas Hierholzer, Martin Fussenegger, Jos Malda, Jos Olijve, Riccardo Levato
Pubblicato in: Advanced Materials, Numero 37, 2025, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202409355

Bioprinting of Human Liver-Derived Epithelial Organoids for Toxicity Studies

Autori: Manon C. Bouwmeester, Paulina Nunez Bernal, Loes A. Oosterhoff, Monique E. van Wolferen, Vivian Lehmann, Monique Vermaas, Maj-Britt Buchholz, Quentin C. Peiffer, Jos Malda, Luc J. W. van der Laan, Nynke I. Kramer, Kerstin Schneeberger, Riccardo Levato, Bart Spee
Pubblicato in: Macromolecular Bioscience, 2021, ISSN 1616-5195
Editore: Wiley
DOI: 10.1002/mabi.202100327

A review of materials used in tomographic volumetric additive manufacturing

Autori: Jorge Madrid-Wolff; Joseph Toombs; Riccardo Rizzo; Paulina Nunez Bernal; Dominique Porcincula; Rebecca Walton; Bin Wang; Frederik Kotz-Helmer; Yi Yang; David Kaplan; Yu Shrike Zhang; Marcy Zenobi-Wong; Robert McLeod; Bastian Rapp; Johanna Schwartz; Maxim Shusteff; Hayden Taylor; Riccardo Levato; Christophe Moser
Pubblicato in: MRS Communications, 2023, ISSN 2159-6867
Editore: Springer
DOI: 10.1557/s43579-023-00447-x

Hybrid Plasmonic Bioresins and dECM-Based Materials for Volumetric Bioprinting of Vascular-Inspired Architectures

Autori: Uxue Aizarna-Lopetegui, Gabriel Größbacher, Ada Herrero-Ruiz, Aitor Tejo-Otero, Malou Henriksen-Lacey, Riccardo Levato, Dorleta Jimenez de Aberasturi
Pubblicato in: ACS Applied Materials & Interfaces, Numero 17, 2025, Pagina/e 36982-36991, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.5c03880

Volumetric Printing across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics

Autori: Gabriel Größbacher, Michael Bartolf-Kopp, Csaba Gergely, Paulina Núñez Bernal, Sammy Florczak, Mylène de Ruijter, Núria Ginés Rodriguez, Jürgen Groll, Jos Malda, Tomasz Jüngst, Riccardo Levato
Pubblicato in: Advanced Materials, 2023, ISSN 1521-4095
Editore: Wiley
DOI: 10.1002/adma.202300756

Shaping Synthetic Multicellular and Complex Multimaterial Tissues via Embedded Extrusion-Volumetric Printing of Microgels

Autori: Davide Ribezzi, MArieme Gueye, Sammy Florczak, Franziska Dusi, Dieuwke de Vos, Francesca Manente, Andreas Hierholzer, Martin Fussenegger, Massimiliano Caiazzo, Torsten Blunk, Jos Malda, Riccardo Levato
Pubblicato in: Advanced Materials, 2023, ISSN 1521-4095
Editore: Wiley
DOI: 10.1002/adma.202301673

Progenitor Cells in Healthy and Osteoarthritic Human Cartilage Have Extensive Culture Expansion Capacity while Retaining Chondrogenic Properties.

Autori: Rikkers, M; Korpershoek, J V; Levato, R; Malda, J; Vonk, L A; Equine Musculoskeletal Biology; dES RMSC; Afd methoden en statistieken
Pubblicato in: Cartilage, 2021, ISSN 1947-6043
Editore: Sage
DOI: 10.1177/19476035211059600

High-resolution lithographic biofabrication of hydrogels with complex microchannels from low-temperature-soluble gelatin bioresins

Autori: Riccardo Levato, Khoon S. Lim, Wanlu Li, Ane Urigoitia Asua, Laura Blanco Peña, Mian Wang, Marc Falandt, Paulina Nuñez Bernal, Debby Gawlitta, Yu Shrike Zhang, Tim B.F. Woodfield, Jos Malda
Pubblicato in: Materials Today Bio, Numero 12, 2021, Pagina/e 100162, ISSN 2590-0064
Editore: Elsevier
DOI: 10.1016/j.mtbio.2021.100162

Development of a bioreactor and volumetric bioprinting protocol to enable perfused culture of biofabricated human epithelial mammary ducts and endothelial constructs

Autori: Maj-Britt Buchholz, Paulina Nunez Bernal, Nils Bessler, Camille Bonhomme, Riccardo Levato, Anne Rios
Pubblicato in: Biofabrication, Numero 17, 2025, Pagina/e 031001, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/add20f

Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges

Autori: Tommaso Zandrini, Sammy Florczak, Riccardo Levato, Aleksandr Ovsianikov
Pubblicato in: Trends in Biotechnology, 2022, ISSN 1879-3096
Editore: Cell Press
DOI: 10.1016/j.tibtech.2022.10.009

Non-destructive assessment of tissue engineered cartilage maturity using visible and near infrared spectroscopy combined with machine learning

Autori: Omar Anwar Elkadi, Florencia Abinzano, Ervin Nippolainen, Ona Bach González, Juha Töyräs, Riccardo Levato, Jos Malda, Isaac O. Afara
Pubblicato in: Biosensors and Bioelectronics, Numero 286, 2025, Pagina/e 117587, ISSN 0956-5663
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2025.117587

Towards single-cell bioprinting: micropatterning tools for organ-on-chip development

Autori: Cecile Bosmans, Nuria Rodriguez, Marcel Karperien, Jos Malda, Liliana Moreira Teixeira, Riccardo Levato, Jeroen Leijten
Pubblicato in: Trends in Biotechnology, 2024, ISSN 1879-3096
Editore: Cell Press, Elsevier
DOI: 10.1016/j.tibtech.2023.11.014

In-Depth Investigation of Electrostatic Interaction-Based Hydrogel Shrinking for Volumetric Printing and Tissue Engineering Applications

Autori: Dmitrii Iudin, Léon J. J. A. Gerridzen, Paulina N. Bernal, Carl C. L. Schuurmans, Myriam Neumann, Lam Nguyen, Mies J. van Steenbergen, Jaimie Hak, Wanlu Li, Cristina Casadidio, Anne Metje van Genderen, Rosalinde Masereeuw, Riccardo Levato, Yu Shrike Zhang, Bas G. P. van Ravensteijn, Tina Vermonden
Pubblicato in: Biomacromolecules, Numero 26, 2025, Pagina/e 4108-4123, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.5c00117

Human breast tissue engineering in health and disease

Autori: Maj-Britt Buchholz, Demi I Scheerman, Riccardo Levato, Ellen J Wehrens, Anne C Rios
Pubblicato in: EMBO Molecular Medicine, Numero 16, 2024, Pagina/e 2299-2321, ISSN 1757-4684
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00112-3

Bioink with cartilage-derived extracellular matrix microfibers enables spatial control of vascular capillary formation in bioprinted constructs

Autori: Margo L Terpstra; Jinyu Li; Anneloes Mensinga; Mylène de Ruijter; Mattie H P van Rijen; Charalampos Androulidakis; Costas Galiotis; Ioannis Papantoniou; Michiya Matsusaki; Jos Malda; Riccardo Levato
Pubblicato in: Biofabrication, 2022, ISSN 1758-5090
Editore: Biofabrication
DOI: 10.1088/1758-5090/ac6282

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories

Autori: Paulina Nunez Bernal, Manon Bouwmeester, Jorge Madrid-Wolff, Marc Falandt, Sammy Florczak, Nuria Gines Rodriguez, Yang Li, Gabriel Groessbacher, Ros-Anne Samsom, Monique van Wolferenc, Luc J.W. van der Laan, Paul Delrot, Damien Loterie, Jos Malda, Christophe Moser, Bart Spee, Riccardo Levato
Pubblicato in: Advanced Materials, 2022, ISSN 1521-4095
Editore: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/adma.202110054

Spatial-Selective Volumetric 4D Printing and Single-Photon Grafting of Biomolecules within Centimeter-Scale Hydrogels via Tomographic Manufacturing

Autori: Marc Falandt; Paulina Bernal; Oksana Dudaryeva; Sammy Florczak; Gabriel Groessbacher; Matthias Schweiger; Alessia Longoni; Coralie Greant; Marisa Assuncao; Olaf Nijssen; Sandra van Vlierberghe; Jos Malda; Tina Vermonden; Riccardo Levato
Pubblicato in: Advanced Materials Technologies, 2023, ISSN 2365-709X
Editore: Wiley
DOI: 10.1002/admt.202300026

Programming Delayed Dissolution Into Sacrificial BioinksFor Dynamic Temporal Control of Architecture within3D-Bioprinted Constructs

Autori: Bram Soliman, Alessia Longoni, Mian Wang, Paulina Nunez Bernal, Alessandro Cianciosi, Gabriella Lindberg, Jos Malda, Juergen Groll, Tomasz Jungst, Riccardo Levato, Jelena Rnjak-Kovacina, Tim Woodfield, Yu Shrike Zhang, Khoon Lim
Pubblicato in: Advanced Functional Materials, 2023, ISSN 1616-3028
Editore: Wiley
DOI: 10.1002/adfm.202210521

Bioprinting and synthetic biology approaches to engineer functional endocrine pancreatic constructs

Autori: Davide Ribezzi, Pere Català, Cataldo Pignatelli, Antonio Citro, Riccardo Levato
Pubblicato in: Trends in Biotechnology, 2025, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2025.03.005

Thesis and dissertations (1)

Crafting Tissue Complexity

Autori: null null, Paulina Núñez Bernal
Pubblicato in: 2024
Editore: Utrecht University Library
DOI: 10.33540/2116

Diritti di proprietà intellettuale

Other (3)

HYBRID SUPRAMOLECULAR BIOMATERIAL FOR BIOPRINTING AND CELL CULTURE

Numero candidatura/pubblicazione: PCT/EP 2023/073303
Data: 2023-08-24
Candidato/i: UNIVERSITAIR MEDISCH CENTRUM UTRECHT

HYBRID SUPRAMOLECULAR BIOMATERIAL FOR BIOPRINTING AND CELL CULTURE

Numero candidatura/pubblicazione: PCT/EP 2023/073303
Data: 2023-08-24
Candidato/i: UNIVERSITEIT UTRECHT

USE OF GELATIN IN A SUPPORT MATERIAL FOR EMBEDDED PRINTING

Numero candidatura/pubblicazione: PCT/EP 2024/060818
Data: 2023-04-21
Candidato/i: UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Patent (1)

SYSTEM AND METHOD FOR GENERATING A THREE-DIMENSIONAL STRUCTURE WITHIN A VOLUME OF CURABLE MATERIAL

Numero candidatura/pubblicazione: 20 24050642
Data: 2024-11-29
Candidato/i: UNIVERSITAIR MEDISCH CENTRUM UTRECHT