Allergic multimorbidity from birth to young adulthood: determinants, epigenetic regulation and inflammatory processes

Project Information

ALLERGENE

Grant agreement ID: 949906

DOI

10.3030/949906

EC signature date 11 December 2020

Start date 1 March 2021

End date 31 August 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 493 330,00

EU contribution

€ 1 493 330,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

DNA methylation and aeroallergen sensitization: The chicken or the egg?

Author(s): Anna Kilanowski, Simon Kebede Merid, Sarina Abrishamcar, Dakotah Feil, Elisabeth Thiering, Melanie Waldenberger, Erik Melén, Annette Peters, Marie Standl, Anke Hüls
Published in: Clinical Epigenetics, Issue 18687083, 2022, ISSN 1868-7083
Publisher: BMC (Part of Springer Nature)
DOI: 10.1186/s13148-022-01332-5

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Author(s): Ashley Budu-Aggrey, Anna Kilanowski, Maria K. Sobczyk, 23andMe Research Team, Suyash S. Shringarpure, Ruth Mitchell, Kadri Reis, Anu Reigo, Estonian Biobank Research Team, Reedik Mägi, Mari Nelis, Nao Tanaka, Ben M. Brumpton, Laurent F. Thomas, Pol Sole-Navais, Christopher Flatley, Antonio Espuela-Ortiz, Esther Herrera-Luis, Jesus V. T. Lominchar, Jette Bork-Jensen, Ingo Marenholz, Aleix Arnau-So
Published in: Nature Communications, 2023, Page(s) 6172, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41180-2

Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies

Author(s): Marie Standl, Ashley Budu‐Aggrey, Luke J. Johnston, Martina S. Elias, S. Hasan Arshad, Peter Bager, Veronique Bataille, Helena Blakeway, Klaus Bønnelykke, Dorret Boomsma, Ben M. Brumpton, Mariona Bustamante Pineda, Archie Campbell, John A. Curtin, Anders Eliasen, João P. S. Fadista, Bjarke Feenstra, Trine Gerner, Carolina Medina‐Gomez, Sarah Grosche, Kristine B. Gutzkow, Anne‐Sofie Halling
Published in: Allergy, Issue 80, 2025, Page(s) 2201-2212, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.16605

Allergic disease trajectories up to adolescence: Characteristics, early-life, and genetic determinants

Author(s): Anna Kilanowski, Elisabeth Thiering, Gang Wang, Ashish Kumar, Sara Kress, Claudia Flexeder, Carl-Peter Bauer, Dietrich Berdel, Andrea von Berg, Anna Bergström, Monika Gappa, Joachim Heinrich, Gunda Herberth, Sibylle Koletzko, Inger Kull, Erik Melén, Tamara Schikowski, Annette Peters, Marie Standl
Published in: Allergy, Issue 13989995, 2022, ISSN 1398-9995
Publisher: Wiley
DOI: 10.1111/all.15511

Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study

Author(s): Natalia Hernandez-Pacheco, Anna Kilanowski, Ashish Kumar, John A. Curtin, Núria Olvera, Sara Kress, Xander Bertels, Lies Lahousse, Laxmi Bhatta, Raquel Granell, Sergi Marí, Jose Ramon Bilbao, Yidan Sun, Casper-Emil Tingskov Pedersen, Tarik Karramass, Elisabeth Thiering, Christina Dardani, Simon Kebede Merid, Gang Wang, Jenny Hallberg, Sarah Koch, Judith Garcia-Aymerich, Ana Esplugues, Maties Tor
Published in: eClinicalMedicine, Issue 75, 2024, Page(s) 102731, ISSN 2589-5370
Publisher: Elsevier BV
DOI: 10.1016/j.eclinm.2024.102731

Trajectories of allergic diseases in children: Destination unknown?

Author(s): Birgit Kalb, Ekaterina Khaleva, Mattia Giovannini, Karine Adel‐Patient, Flore Amat, Stefania Arasi, Susanne Lau, Antonio Nieto, Bianca Schaub, Marie Standl, Jonathan O'B Hourihane, Philippe Eigenmann, Antoine Deschildre, null null
Published in: Pediatric Allergy and Immunology, Issue 36, 2025, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.70131

Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging

Author(s): Miriam Leskien, Elisabeth Thiering, Zhebin Yu, Anke Huels, Yueli Yao, Simon Kebede Merid, Olena Gruzieva, Stephan Weidinger, Melanie Waldenberger, Annette Peters, Erik Melén, Marie Standl
Published in: Allergy, Issue 80, 2025, Page(s) 1912-1922, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.16583

a meta-analysis of 150 000 European children

Author(s): van Meel, Evelien R; Mensink-Bout, Sara M; den Dekker, Herman T; Ahluwalia, Tarunveer S; Annesi-Maesano, Isabella; Arshad, Syed Hasan; Baïz, Nour; Barros, Henrique; von Berg, Andrea; Bisgaard, Hans; Bønnelykke, Klaus; Carlsson, Christian J; Casas, Maribel; Chatzi, Leda; Chevrier, Cecile; Dalmeijer, Geertje; Dezateux, Carol; Duchen, Karel; Eggesbø, Merete; van der Ent, Cornelis; Fantini, Maria;
Published in: European Respiratory Journal, Issue 60, 2022, Page(s) 2102395, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.48350/169634

Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative

Author(s): Carlos A. Valencia-Hernández, Zhebin Yu, Ulrike Gehring, Gerard H. Koppelman, Marie Standl, Claudia Flexeder, Tamara Schikowski, Sara Kress, Erik Melén, Olena Gruzieva, Mare Lõhmus, Rosa Faner, Alvar Agusti, Jadwiga A. Wedzicha, Judith Garcia-Aymerich, Sarah Koch, Mark Nieuwenhuijsen, Aitana Lertxundi, Ana Esplugues, Ferran Ballester, Ane Arregi, Iana Markevych, Chloe I. Bloom, Elaine Fuertes
Published in: Environment International, Issue 199, 2025, Page(s) 109493, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2025.109493

External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project

Author(s): Zhebin Yu, Sara Kress, Natalia Blay, Petr Gregor, Hanna-Maria Kukk, Miriam Leskien, Renata Majewska, Max J. Oosterwegel, Daniel Szabó, Margreet ten Have, Jana Klánová, Ondřej Mikeš, Anna Bergström, Alonso Bussalleu, Rafael de Cid, Andrea Dalecka, Payam Dadvand, Saskia van Dorsselaer, Krista Fischer, Kees de Hoogh, Gerard H. Koppelman, Jaanika Kronberg, Andres Metspalu, Lili Milani, Tõnu Esk
Published in: The Lancet Regional Health - Europe, Issue 54, 2025, Page(s) 101314, ISSN 2666-7762
Publisher: Elsevier BV
DOI: 10.1016/j.lanepe.2025.101314

Accelerometry-assessed sleep clusters and obesity in adolescents and young adults: a longitudinal analysis in GINIplus/LISA birth cohorts

Author(s): Mingming Wang, Claudia Flexeder, Carla P. Harris, Sara Kress, Tamara Schikowski, Annette Peters, Marie Standl
Published in: World Journal of Pediatrics, Issue 21, 2025, Page(s) 48-61, ISSN 1708-8569
Publisher: Springer Verlag
DOI: 10.1007/s12519-024-00872-5

Maternal exposure to polychlorinated biphenyls in indoor air and asthma, allergic rhinitis, atopic eczema, and respiratory tract infections in childhood

Author(s): Laura Deen, Karin Sørig Hougaard, Harald William Meyer, Camilla Sandal Sejbæk, Kajsa Ugelvig Petersen, Marie Frederiksen, Jens Peter Bonde, Marie Standl, Claudia Flexeder, Sandra Søgaard Tøttenborg
Published in: International Journal of Hygiene and Environmental Health, Issue 266, 2025, Page(s) 114567, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2025.114567

Methylation risk scores for childhood aeroallergen sensitization: Results from the LISA birth cohort

Author(s): Anna Kilanowski, Junyu Chen, Todd Everson, Elisabeth Thiering, Rory Wilson, Nicole Gladish, Melanie Waldenberger, Hongmei Zhang, Juan C. Celedón, Esteban G. Burchard, Annette Peters, Marie Standl, Anke Hüls
Published in: Allergy, 2022, ISSN 1398-9995
Publisher: Wiley
DOI: 10.1111/all.15315

Prospective association between psychopathological symptoms in childhood and asthma in adolescence: Results from the GINIplus and LISA birth cohort studies

Author(s): Pia‐Marie Keim, Ellen Greimel, Lisa Feldmann, Charlotte Elisabeth Piechaczek, Carla P. Harris, Claudia Flexeder, Dietrich Berdel, Andrea von Berg, Sibylle Koletzko, Carl‐Peter Bauer, Tamara Schikowski, Gunda Herberth, Joachim Heinrich, Gerd Schulte‐Körne, Marie Standl
Published in: Pediatric Allergy and Immunology, Issue 36, 2025, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.70151