Allergic multimorbidity from birth to young adulthood: determinants, epigenetic regulation and inflammatory processes

Informazioni relative al progetto

ALLERGENE

ID dell’accordo di sovvenzione: 949906

DOI

10.3030/949906

Data della firma CE 11 Dicembre 2020

Data di avvio 1 Marzo 2021

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 493 330,00

Contributo UE

€ 1 493 330,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (14)

DNA methylation and aeroallergen sensitization: The chicken or the egg?

Autori: Anna Kilanowski, Simon Kebede Merid, Sarina Abrishamcar, Dakotah Feil, Elisabeth Thiering, Melanie Waldenberger, Erik Melén, Annette Peters, Marie Standl, Anke Hüls
Pubblicato in: Clinical Epigenetics, Numero 18687083, 2022, ISSN 1868-7083
Editore: BMC (Part of Springer Nature)
DOI: 10.1186/s13148-022-01332-5

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Autori: Ashley Budu-Aggrey, Anna Kilanowski, Maria K. Sobczyk, 23andMe Research Team, Suyash S. Shringarpure, Ruth Mitchell, Kadri Reis, Anu Reigo, Estonian Biobank Research Team, Reedik Mägi, Mari Nelis, Nao Tanaka, Ben M. Brumpton, Laurent F. Thomas, Pol Sole-Navais, Christopher Flatley, Antonio Espuela-Ortiz, Esther Herrera-Luis, Jesus V. T. Lominchar, Jette Bork-Jensen, Ingo Marenholz, Aleix Arnau-So
Pubblicato in: Nature Communications, 2023, Pagina/e 6172, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-41180-2

Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies

Autori: Marie Standl, Ashley Budu‐Aggrey, Luke J. Johnston, Martina S. Elias, S. Hasan Arshad, Peter Bager, Veronique Bataille, Helena Blakeway, Klaus Bønnelykke, Dorret Boomsma, Ben M. Brumpton, Mariona Bustamante Pineda, Archie Campbell, John A. Curtin, Anders Eliasen, João P. S. Fadista, Bjarke Feenstra, Trine Gerner, Carolina Medina‐Gomez, Sarah Grosche, Kristine B. Gutzkow, Anne‐Sofie Halling
Pubblicato in: Allergy, Numero 80, 2025, Pagina/e 2201-2212, ISSN 0105-4538
Editore: Blackwell Publishing Inc.
DOI: 10.1111/all.16605

Allergic disease trajectories up to adolescence: Characteristics, early-life, and genetic determinants

Autori: Anna Kilanowski, Elisabeth Thiering, Gang Wang, Ashish Kumar, Sara Kress, Claudia Flexeder, Carl-Peter Bauer, Dietrich Berdel, Andrea von Berg, Anna Bergström, Monika Gappa, Joachim Heinrich, Gunda Herberth, Sibylle Koletzko, Inger Kull, Erik Melén, Tamara Schikowski, Annette Peters, Marie Standl
Pubblicato in: Allergy, Numero 13989995, 2022, ISSN 1398-9995
Editore: Wiley
DOI: 10.1111/all.15511

Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study

Autori: Natalia Hernandez-Pacheco, Anna Kilanowski, Ashish Kumar, John A. Curtin, Núria Olvera, Sara Kress, Xander Bertels, Lies Lahousse, Laxmi Bhatta, Raquel Granell, Sergi Marí, Jose Ramon Bilbao, Yidan Sun, Casper-Emil Tingskov Pedersen, Tarik Karramass, Elisabeth Thiering, Christina Dardani, Simon Kebede Merid, Gang Wang, Jenny Hallberg, Sarah Koch, Judith Garcia-Aymerich, Ana Esplugues, Maties Tor
Pubblicato in: eClinicalMedicine, Numero 75, 2024, Pagina/e 102731, ISSN 2589-5370
Editore: Elsevier BV
DOI: 10.1016/j.eclinm.2024.102731

Trajectories of allergic diseases in children: Destination unknown?

Autori: Birgit Kalb, Ekaterina Khaleva, Mattia Giovannini, Karine Adel‐Patient, Flore Amat, Stefania Arasi, Susanne Lau, Antonio Nieto, Bianca Schaub, Marie Standl, Jonathan O'B Hourihane, Philippe Eigenmann, Antoine Deschildre, null null
Pubblicato in: Pediatric Allergy and Immunology, Numero 36, 2025, ISSN 0905-6157
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pai.70131

Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging

Autori: Miriam Leskien, Elisabeth Thiering, Zhebin Yu, Anke Huels, Yueli Yao, Simon Kebede Merid, Olena Gruzieva, Stephan Weidinger, Melanie Waldenberger, Annette Peters, Erik Melén, Marie Standl
Pubblicato in: Allergy, Numero 80, 2025, Pagina/e 1912-1922, ISSN 0105-4538
Editore: Blackwell Publishing Inc.
DOI: 10.1111/all.16583

a meta-analysis of 150 000 European children

Autori: van Meel, Evelien R; Mensink-Bout, Sara M; den Dekker, Herman T; Ahluwalia, Tarunveer S; Annesi-Maesano, Isabella; Arshad, Syed Hasan; Baïz, Nour; Barros, Henrique; von Berg, Andrea; Bisgaard, Hans; Bønnelykke, Klaus; Carlsson, Christian J; Casas, Maribel; Chatzi, Leda; Chevrier, Cecile; Dalmeijer, Geertje; Dezateux, Carol; Duchen, Karel; Eggesbø, Merete; van der Ent, Cornelis; Fantini, Maria;
Pubblicato in: European Respiratory Journal, Numero 60, 2022, Pagina/e 2102395, ISSN 0903-1936
Editore: European Respiratory Society
DOI: 10.48350/169634

Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative

Autori: Carlos A. Valencia-Hernández, Zhebin Yu, Ulrike Gehring, Gerard H. Koppelman, Marie Standl, Claudia Flexeder, Tamara Schikowski, Sara Kress, Erik Melén, Olena Gruzieva, Mare Lõhmus, Rosa Faner, Alvar Agusti, Jadwiga A. Wedzicha, Judith Garcia-Aymerich, Sarah Koch, Mark Nieuwenhuijsen, Aitana Lertxundi, Ana Esplugues, Ferran Ballester, Ane Arregi, Iana Markevych, Chloe I. Bloom, Elaine Fuertes
Pubblicato in: Environment International, Numero 199, 2025, Pagina/e 109493, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2025.109493

External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project

Autori: Zhebin Yu, Sara Kress, Natalia Blay, Petr Gregor, Hanna-Maria Kukk, Miriam Leskien, Renata Majewska, Max J. Oosterwegel, Daniel Szabó, Margreet ten Have, Jana Klánová, Ondřej Mikeš, Anna Bergström, Alonso Bussalleu, Rafael de Cid, Andrea Dalecka, Payam Dadvand, Saskia van Dorsselaer, Krista Fischer, Kees de Hoogh, Gerard H. Koppelman, Jaanika Kronberg, Andres Metspalu, Lili Milani, Tõnu Esk
Pubblicato in: The Lancet Regional Health - Europe, Numero 54, 2025, Pagina/e 101314, ISSN 2666-7762
Editore: Elsevier BV
DOI: 10.1016/j.lanepe.2025.101314

Accelerometry-assessed sleep clusters and obesity in adolescents and young adults: a longitudinal analysis in GINIplus/LISA birth cohorts

Autori: Mingming Wang, Claudia Flexeder, Carla P. Harris, Sara Kress, Tamara Schikowski, Annette Peters, Marie Standl
Pubblicato in: World Journal of Pediatrics, Numero 21, 2025, Pagina/e 48-61, ISSN 1708-8569
Editore: Springer Verlag
DOI: 10.1007/s12519-024-00872-5

Maternal exposure to polychlorinated biphenyls in indoor air and asthma, allergic rhinitis, atopic eczema, and respiratory tract infections in childhood

Autori: Laura Deen, Karin Sørig Hougaard, Harald William Meyer, Camilla Sandal Sejbæk, Kajsa Ugelvig Petersen, Marie Frederiksen, Jens Peter Bonde, Marie Standl, Claudia Flexeder, Sandra Søgaard Tøttenborg
Pubblicato in: International Journal of Hygiene and Environmental Health, Numero 266, 2025, Pagina/e 114567, ISSN 1438-4639
Editore: Elsevier BV
DOI: 10.1016/j.ijheh.2025.114567

Methylation risk scores for childhood aeroallergen sensitization: Results from the LISA birth cohort

Autori: Anna Kilanowski, Junyu Chen, Todd Everson, Elisabeth Thiering, Rory Wilson, Nicole Gladish, Melanie Waldenberger, Hongmei Zhang, Juan C. Celedón, Esteban G. Burchard, Annette Peters, Marie Standl, Anke Hüls
Pubblicato in: Allergy, 2022, ISSN 1398-9995
Editore: Wiley
DOI: 10.1111/all.15315

Prospective association between psychopathological symptoms in childhood and asthma in adolescence: Results from the GINIplus and LISA birth cohort studies

Autori: Pia‐Marie Keim, Ellen Greimel, Lisa Feldmann, Charlotte Elisabeth Piechaczek, Carla P. Harris, Claudia Flexeder, Dietrich Berdel, Andrea von Berg, Sibylle Koletzko, Carl‐Peter Bauer, Tamara Schikowski, Gunda Herberth, Joachim Heinrich, Gerd Schulte‐Körne, Marie Standl
Pubblicato in: Pediatric Allergy and Immunology, Numero 36, 2025, ISSN 0905-6157
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pai.70151