Biocatalytic alkylation: fitting enzymes for selective C-C bond formations

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Peroxygenase-catalyzed allylic oxidation unlocks telescoped synthesis of (1S,3R)-3-hydroxycyclohexanecarbonitrile

Autores: Christian M. Heckmann; Mortiz Bürgler; Caroline E. Paul
Publicado en: ACS Catalysis, Edición 1, 2024, Página(s) 2985-2991, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.4c00177

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

Autores: Linyue Zhang; Edward King; William B. Black; Christian M. Heckmann; Allison Wolder; Youtian Cui; Francis Nicklen; Justin B. Siegel; Ray Luo; Caroline E. Paul; Han Li
Publicado en: Nature Communications, Edición 1, 2022, Página(s) 5021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32727-w

Enantio-Complementary Synthesis of 2-Substituted Pyrrolidines and Piperidines via Transaminase-Triggered Cyclizations

Autores: Christian M. Heckmann; Caroline E. Paul
Publicado en: JACS Au, 2023, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/jacsau.3c00103

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Autores: Rocio Villa; Claudia Ferrer-Carbonell; Caroline E. Paul
Publicado en: Catalysis Science & Technology, 2023, ISSN 2044-4753
Editor: Royal Society of Chemistry
DOI: 10.1039/d3cy00541k

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