Biocatalytic alkylation: fitting enzymes for selective C-C bond formations

Project Information

BioAlk

Grant agreement ID: 949910

DOI 10.3030/949910

EC signature date 1 September 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 625 000,00

EU contribution € 1 625 000,00

Coordinated by

TECHNISCHE UNIVERSITEIT DELFT
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Peroxygenase-catalyzed allylic oxidation unlocks telescoped synthesis of (1S,3R)-3-hydroxycyclohexanecarbonitrile

Author(s): Christian M. Heckmann; Mortiz Bürgler; Caroline E. Paul
Published in: ACS Catalysis, Issue 1, 2024, Page(s) 2985-2991, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c00177

Artificial Biocatalysis: Quo Vadis?

Author(s): Aaron A. Ingram, Keiko Oike
Published in: ChemCatChem, 2024, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202301759

Insights into <i>E. coli</i> Cyclopropane Fatty Acid Synthase (CFAS) Towards Enantioselective Carbene Free Biocatalytic Cyclopropanation.

Author(s): Iman Omar, Michele Crotti, Chuhan Li, Krisztina Pisak, Blazej Czemerys, Salvatore Ferla, Aster van Noord, Caroline E. Paul, Kersti Karu, Cagakan Ozbalci, Ulrike Eggert, Richard Lloyd, Sarah M. Barry, Daniele Castagnolo
Published in: Angewandte Chemie International Edition, Issue 63, 2024, Page(s) e202403493, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202403493

Ene‐Reductase‐Catalyzed Oxidation Reactions

Author(s): Jacob M.A. van Hengst, Allison E. Wolder, Marisa Sánchez, Mieke M. E. Huijbers, Diederik J. Opperman, Pierre Gilles, Juliette Martin, Thomas Hilberath, Frank Hollmann, Caroline E. Paul
Published in: ChemCatChem, 2024, Page(s) e202401447, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202401447

H2-driven biocatalysis for flavin-dependent ene-reduction in a continuous closed-loop flow system utilizing H2 from water electrolysis

Author(s): Guiyeoul Lim, Donato Calabrese, Allison Wolder, Paul R. F. Cordero, Dörte Rother, Florian F. Mulks, Caroline E. Paul, Lars Lauterbach
Published in: Communications Chemistry, Issue 7, 2024, Page(s) 200, ISSN 2399-3669
Publisher: Springer Nature
DOI: 10.1038/s42004-024-01288-y

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

Author(s): Linyue Zhang; Edward King; William B. Black; Christian M. Heckmann; Allison Wolder; Youtian Cui; Francis Nicklen; Justin B. Siegel; Ray Luo; Caroline E. Paul; Han Li
Published in: Nature Communications, Issue 1, 2022, Page(s) 5021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32727-w

Enantio-Complementary Synthesis of 2-Substituted Pyrrolidines and Piperidines via Transaminase-Triggered Cyclizations

Author(s): Christian M. Heckmann; Caroline E. Paul
Published in: JACS Au, 2023, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00103

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Author(s): Rocio Villa; Claudia Ferrer-Carbonell; Caroline E. Paul
Published in: Catalysis Science & Technology, 2023, ISSN 2044-4753
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cy00541k

Asymmetric Monoreduction of α,β-Dicarbonyls to α-Hydroxy Carbonyls by Ene Reductases

Author(s): Allison E. Wolder, Christian M. Heckmann, Peter-Leon Hagedoorn, Diederik J. Opperman, Caroline E. Paul
Published in: ACS Catalysis, 2024, Page(s) 15713-15720, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c04676