Biocatalytic alkylation: fitting enzymes for selective C-C bond formations

Project Information

BioAlk

Grant agreement ID: 949910

DOI

10.3030/949910

Project closed

EC signature date 1 September 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 625 000,00

EU contribution

€ 1 625 000,00

Coordinated by

TECHNISCHE UNIVERSITEIT DELFT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Enantioselective synthesis of (<i>R</i>)-citronellal from geraniol with an immobilised copper alcohol oxidase and ene reductase

Author(s): Beatrice Tagliabue, Christian M. Heckmann, Rocio Villa, Sacha Grisel, Jean-Guy Berrin, Mickael Lafond, David Ribeaucourt, Caroline E. Paul
Published in: Reaction Chemistry &amp; Engineering, Issue 10, 2025, Page(s) 1320-1325, ISSN 2058-9883
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5re00034c

Peroxygenase-catalyzed allylic oxidation unlocks telescoped synthesis of (1S,3R)-3-hydroxycyclohexanecarbonitrile

Author(s): Christian M. Heckmann; Mortiz Bürgler; Caroline E. Paul
Published in: ACS Catalysis, Issue 1, 2024, Page(s) 2985-2991, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c00177

Artificial Biocatalysis: Quo Vadis?

Author(s): Aaron A. Ingram, Keiko Oike
Published in: ChemCatChem, 2024, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202301759

Insights into <i>E. coli</i> Cyclopropane Fatty Acid Synthase (CFAS) Towards Enantioselective Carbene Free Biocatalytic Cyclopropanation.

Author(s): Iman Omar, Michele Crotti, Chuhan Li, Krisztina Pisak, Blazej Czemerys, Salvatore Ferla, Aster van Noord, Caroline E. Paul, Kersti Karu, Cagakan Ozbalci, Ulrike Eggert, Richard Lloyd, Sarah M. Barry, Daniele Castagnolo
Published in: Angewandte Chemie International Edition, Issue 63, 2024, Page(s) e202403493, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202403493

Pioneering Women Shaping the Field of Biocatalysis

Author(s): Ana I. Benítez‐Mateos, Caroline E. Paul, Sandy Schmidt, Martina Letizia Contente
Published in: ChemCatChem, Issue 17, 2025, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202500088

Asymmetric Enantio-complementary Synthesis of Thioethers via Ene-Reductase-Catalyzed C–C Bond Formation

Author(s): Christian M. Heckmann, Derren J. Heyes, Martin Pabst, Edwin Otten, Nigel S. Scrutton, Caroline E. Paul
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 18618-18625, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5c00761

Ene‐Reductase‐Catalyzed Oxidation Reactions

Author(s): Jacob M.A. van Hengst, Allison E. Wolder, Marisa Sánchez, Mieke M. E. Huijbers, Diederik J. Opperman, Pierre Gilles, Juliette Martin, Thomas Hilberath, Frank Hollmann, Caroline E. Paul
Published in: ChemCatChem, 2024, Page(s) e202401447, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202401447

H2-driven biocatalysis for flavin-dependent ene-reduction in a continuous closed-loop flow system utilizing H2 from water electrolysis

Author(s): Guiyeoul Lim, Donato Calabrese, Allison Wolder, Paul R. F. Cordero, Dörte Rother, Florian F. Mulks, Caroline E. Paul, Lars Lauterbach
Published in: Communications Chemistry, Issue 7, 2024, Page(s) 200, ISSN 2399-3669
Publisher: Springer Nature
DOI: 10.1038/s42004-024-01288-y

Discovery and Synthetic Applications of a NAD(P)H-Dependent Reductive Aminase from <i>Rhodococcus erythropolis</i>

Author(s): Ewald P. J. Jongkind, Jack Domenech, Arthur Govers, Marcel van den Broek, Jean-Marc Daran, Gideon Grogan, Caroline E. Paul
Published in: ACS Catalysis, Issue 15, 2025, Page(s) 211-219, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c04935

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

Author(s): Linyue Zhang; Edward King; William B. Black; Christian M. Heckmann; Allison Wolder; Youtian Cui; Francis Nicklen; Justin B. Siegel; Ray Luo; Caroline E. Paul; Han Li
Published in: Nature Communications, Issue 1, 2022, Page(s) 5021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32727-w

Enantio-Complementary Synthesis of 2-Substituted Pyrrolidines and Piperidines via Transaminase-Triggered Cyclizations

Author(s): Christian M. Heckmann; Caroline E. Paul
Published in: JACS Au, 2023, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00103

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Author(s): Rocio Villa; Claudia Ferrer-Carbonell; Caroline E. Paul
Published in: Catalysis Science & Technology, 2023, ISSN 2044-4753
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cy00541k

Asymmetric Monoreduction of α,β-Dicarbonyls to α-Hydroxy Carbonyls by Ene Reductases

Author(s): Allison E. Wolder, Christian M. Heckmann, Peter-Leon Hagedoorn, Diederik J. Opperman, Caroline E. Paul
Published in: ACS Catalysis, 2024, Page(s) 15713-15720, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c04676

Enzymatic Synthesis of Enantiopure (<i>R</i>)‐Citronellal from Geraniol via a Short‐Chain Dehydrogenase and Ene Reductase

Author(s): Claudia Ferrer‐Carbonell, Rocio Villa, Iris Viskaal, Diederik J. Opperman, Caroline E. Paul
Published in: Advanced Synthesis &amp; Catalysis, Issue 367, 2025, Page(s) e202500060, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202500060

Non-peer reviewed articles (1)

Harnessing a versatile monooxygenase GorA to synthesize N-hydroxy compounds

Author(s): Caroline E. Paul
Published in: Chem Catalysis, Issue 5, 2025, Page(s) 101495, ISSN 2667-1093
Publisher: Elsevier BV
DOI: 10.1016/j.checat.2025.101495

Other (1)

Asymmetric Enantio-Complementary Synthesis of Thioethers via Ene-Reductase Catalysed C-C bond formation

Author(s): Christian M. Heckmann, Derren J. Heyes, Martin Pabst, Edwin Otten, Nigel S. Scrutton, Caroline E. Paul
Published in: 2024
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-shnqc