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Beyond super-resolution: ultra-resolution imaging provides solutions for synapse physiology and brain pathology

Project description

Development of ultra-resolution imaging for brain synapse studies

Modern imaging technologies are unable to present the topology of proteins accurately as the best super-resolution tools’ limits are at 20–30 nm, which is several times more than the sizes of the individual proteins. The EU-funded ULTRARESOLUTION project aims to develop reliable ultra-resolution imaging with a true molecular resolution of 1–5 nm. The project will combine optics-based super-resolution technologies with the innovative physical expansion of the samples. This approach will be employed to decipher the functional organisation of key components in brain synapses. The final goal is to establish simple protocols to expand the application of ultra resolution to every biomedical laboratory.

Call for proposal

ERC-2020-SyG
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Host institution

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Address
Robert-koch-strasse 40
37075 Goettingen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 078 736

Beneficiaries (3)

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 3 078 736
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
United States
EU contribution
€ 3 645 000
Address
Massachusetts Avenue 77
02139 Cambridge
Activity type
Higher or Secondary Education Establishments
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 4 376 485
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments