Structure and functions of the brain extracellular space

Project description

Shedding light on the black areas between brain cells

The extracellular space (ECS) is the black area between the cells of the brain where many physiological events unfold at the same time. Despite its importance, the ECS remains a mystery mainly due to the absence of dedicated investigation strategies. The ERC-funded ENSEMBLE project will shed light on the conceptual and methodological roadblocks that prevent further understanding of the fine architecture of the ECS and how molecules navigate within it throughout the brain. It will unveil in vivo the structure and functions and propose a new theoretical framework. ENSEMBLE will determine whether molecular diffusion in the ECS is locally regulated by the properties of the ECS.

Fields of science

• natural sciences › biological sciences › neurobiology
• medical and health sciences › basic medicine › physiology › pathophysiology
• natural sciences › physical sciences › optics › microscopy › super resolution microscopy
• medical and health sciences › basic medicine › immunology › immunotherapy
• natural sciences › biological sciences › molecular biology › molecular neuroscience

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2020-SyG - ERC Synergy Grant

Call for proposal

ERC-2020-SyG

See other projects for this call

Funding Scheme

ERC-SyG - Synergy grant

Host institution

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Net EU contribution

€ 5 085 310,00

Address

Rue Michel Ange 3
75794 Paris
France

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

€ 0,00

Beneficiaries (3)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

Net EU contribution

€ 5 085 310,00

Address

Rue Michel Ange 3
75794 Paris

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

€ 0,00

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Net EU contribution

€ 2 407 637,50

Address

Rue De Tolbiac 101
75654 Paris

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

€ 0,00

UNIVERSITE DE BORDEAUX

France

Net EU contribution

€ 2 499 525,00

Address

Place Pey Berland 35
33000 Bordeaux

Region

Nouvelle-Aquitaine › Aquitaine › Gironde

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00