Analysis of the T cell’s Tactical Arsenal for Cancer Killing

Información del proyecto

ATTACK

Identificador del acuerdo de subvención: 951329

DOI

10.3030/951329

Fecha de la firma de la CE 25 Abril 2021

Fecha de inicio 1 Mayo 2021

Fecha de finalización 30 Abril 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 9 999 019,00

Aportación de la UE

€ 9 999 017,00

Coordinado por

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (28)

Lytic granule exocytosis at immune synapses: lessons from neuronal synapses

Autores: Hsin-Fang Chang; Claudia Schirra; Varsha Pattu; Elmar Krause; Ute Becherer
Publicado en: Frontiers in Immunology, 2023, ISSN 1664-3224
Editor: Frontiers Media S.A
DOI: 10.3389/fimmu.2023.1177670

Greek Fire, Poison Arrows, and Scorpion Bombs: How Tumor Cells Defend Against the Siege Weapons of Cytotoxic T Lymphocytes

Autores: McKenzie B, Khazen R, Valitutti S
Publicado en: Frontiers in Immunology, Edición 16643224, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.894306

Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)

Autores: Chiara Cassioli; Laura Patrussi; Salvatore Valitutti; Cosima T. Baldari
Publicado en: International Journal of Molecular Sciences, Edición Monthly, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232214255

Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation

Autores: Kristina Zec, Barbora Schonfeldova, Zhichao Ai, Erinke Van Grinsven, Gabriela Pirgova, Hayley L. Eames, Dorothée L. Berthold, Moustafa Attar, Ewoud B. Compeer, Tal I. Arnon, Irina A. Udalova
Publicado en: Journal of Experimental Medicine, Edición 220, 2023, Página(s) e20220595., ISSN 1540-9538
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220595

The Expanding Arsenal of Cytotoxic T Cells

Autores: Chiara Cassioli, Cosima Tatiana Baldari
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.883010

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Autores: Hsin-Fang Chang; Claudia Schirra; Momchil Ninov; Ulrike Hahn; Keerthana Ravichandran; Elmar Krause; Ute Becherer; Štefan Bálint; Maria Harkiolaki; Henning Urlaub; Salvatore Valitutti; Cosima T. Baldari; Michael L. Dustin; Reinhard Jahn; Jens Rettig
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28596-y

Comparison of different methods for isolating CD8+ T lymphocyte-derived extracellular vesicles and supramolecular attack particles

Autores: Ashwin K. Jainarayanan, Jesusa Capera, Pablo F. Céspedes, Mariana Conceição, Mirudula Elanchezhian, Tom Thomas, Scott Bonner, Salvatore Valvo, Elke Kurz, Ranjeet Singh Mahla, Georgina Berridge, Svenja Hester, Roman Fischer, Lynn B. Dustin, Matthew J. A. Wood, Michael L. Dustin
Publicado en: Journal of Extracellular Biology, Edición 2, 2023, ISSN 2768-2811
Editor: International Society for Extracellular Vesicles
DOI: 10.1002/jex2.74

A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

Autores: Nagaja Capitani; Anna Onnis; Francesca Finetti; Chiara Cassioli; Alessandro Plebani; Jlenia Brunetti; Arianna Troilo; Sofia D'Elios; Manuela Baronio; Luisa Gazzurelli; Chiara Della Bella; Daniel D Billadeau; Mario Milco D'Elios; Vassilios Lougaris; Cosima T Baldari
Publicado en: Cell Death & Differentiation, 2022, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00837-5

Emerging roles of SARS-CoV-2 Spike/ACE2 in immune evasion and pathogenesis

Autores: Cosima T. Baldari; Anna Onnis; Emanuele Andreano; Giuseppe Del Giudice; Rino Rappuoli
Publicado en: Trends in Immunology, Edición 44, 2023, Página(s) 424-434, ISSN 1471-4981
Editor: Elsevier Ltd
DOI: 10.1016/j.it.2023.04.001

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK3 activation and PD-1 expression

Autores: Montecchi T, Nannini G, De Tommaso D, Cassioli C, Monaci S, Coppola F, Ringressi Mn, Naldini A, Taddei A, Marotta G, Amedei A, Baldari CT, Ulivieri C
Publicado en: Cancer Immunology, Immunotherapy, Edición 73, 2024, Página(s) 2, ISSN 1432-0851
Editor: Springer
DOI: 10.1007/s00262-023-03614-0

A solution for highly efficient electroporation of primary cytotoxic T lymphocytes

Autores: Alawar N, Schirra C, Hohmann M, Becherer U
Publicado en: BMC Biotechnology, Edición 24, 2024, Página(s) 16, ISSN 1472-6750
Editor: BioMed Central
DOI: 10.1186/s12896-024-00839-4

IFT20: An Eclectic Regulator of Cellular Processes beyond Intraflagellar Transport.

Autores: Francesca Finetti; Anna Onnis; Cosima T. Baldari
Publicado en: International Journal of Molecular Science, Edición Monthly, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232012147

p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-κB

Autores: Tatangelo V, Boncompagni G, Capitani N, Lopresti L, Manganaro N, Frezzato F, Visentin A, Trentin L, Baldari CT, Patrussi L
Publicado en: Frontiers in Oncology, Edición 12, 2022, Página(s) 877495, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.877495

Lymphocyte Polarization During Immune Synapse Assembly: Centrosomal Actin Joins the Game

Autores: Chiara Cassioli; Cosima T. Baldari
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.830835

An AMBRA1, ULK1 and PP2A regulatory network regulates cytotoxic T cell differentiation via TFEB activation

Autores: Loredana Migliore, Valentina Cianfanelli, Fabrizia Zevolini, Monica Gesualdo, Leandro Marzuoli, Laura Patrussi, Cristina Ulivieri, Giuseppe Marotta, Francesco Cecconi, Francesca Finetti, Cosima T. Baldari
Publicado en: Scientific Reports, Edición 14, 2024, Página(s) e2413866122, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-82957-9

SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

Autores: Anna Onnis; Emanuele Andreano; Chiara Cassioli; Francesca Finetti; Chiara Della Bella; Oskar Staufer; Elisa Pantano; Valentina Abbiento; Giuseppe Marotta; Mario Milco D’Elios; Rino Rappuoli; Cosima T. Baldari
Publicado en: Journal of Experimental Medicine, Edición Monthly, 2023, ISSN 1540-9538
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220906

Ultra-rapid lytic granule release from CTL activates Ca2+-dependent synaptic resistance pathways in melanoma cell

Autores: Liza Filali; Marie-Pierre Puissegur; Kevin Cortacero; Sylvain Cussat-Blanc; Roxana Khazen; Nathalie Van Acker; François-Xavier Frenois, Arnaud Abreu; Laurence Lamant; Nicolas Meyer, Béatrice Vergier; Sabina Müller; Brienne McKenzie; Salvatore Valitutti
Publicado en: Science Advances, 2022, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abk3234

Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles

Autores: Chiara Cassioli, Nagaja Capitani, Claire C. Staton, Claudia Schirra, Francesca Finetti, Anna Onnis, Nadia Alawar, Szu-Min Tu, Ludovica Lopresti, Vanessa Tatangelo, Carmela Tangredi, Salvatore Valvo, Hsin-Fang Chang, Annachiara Miccoli, Ewoud B. Compeer, Jemma Nicholls, Bruce R. Blazar, Giuseppe Marotta, Matthew J. A. Wood, Livio Trentin, Laura Patrussi, Michael L. Dustin, Ute Becherer, Cosima T. B
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, Página(s) e2413866122, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2413866122

Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy

Autores: Ludovica Lopresti, Vanessa Tatangelo, Cosima T. Baldari, Laura Patrussi
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1418527

Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia

Autores: Boncompagni G, Tatangelo V, Lopresti L, Ulivieri C, Capitani N, Tangredi C, Marotta G, Frezzato F, Visentin A, Ciofini S, Gozzetti A, Calzada-Fraile D, Martin Cofreces NB, Trentin L, Patrussi L, Baldari CT
Publicado en: Cell Death & Disease, Edición 15, 2024, Página(s) 144, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-024-06528-6

Resisting T cell attack: tumor-cell-intrinsic defense and reparation mechanisms

Autores: Brienne McKenzie, Salvatore Valitutti
Publicado en: Trends in Cancer, Edición 9, 2023, Página(s) 198-211, ISSN 2405-8033
Editor: Elsevier Inc.
DOI: 10.1016/j.trecan.2022.12.003

The Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens

Autores: Nagaja Capitani; Cosima Tatiana Baldari
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.943344

Increasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells

Autores: Chiara Cassioli; Stefan Balint; Ewoud B Compeer; James H Felce; Alessandra Gamberucci; Chiara Della Bella; Suet Ling Felce; Jlenia Brunetti; Salvatore Valvo; Daniela Pende; Mario M D’Elios; Lorenzo Moretta; Michael L Dustin; Cosima T Baldari
Publicado en: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.673446

Evolutionary design of explainable algorithms for biomedical image segmentation

Autores: Cortacero K, McKenzie B, Müller S, Khazen R, Lafouresse F, Corsaut G, Van Acker N, Frenois F-X, Lamant L, Meyer N, Vergier B, Wilson DG, Luga H, Staufer S, Dustin ML, Valitutti S, Cussat-Blanc S
Publicado en: Nature Communications, Edición 14, 2023, Página(s) 7112, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42664-x

The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly

Autores: Chiara Cassioli; Anna Onnis; Francesca Finetti; Nagaja Capitani; Jlenia Brunetti; Ewoud B Compeer; Veronika Niederlova; Ondrej Stepanek; Michael L Dustin; Cosima T Baldari
Publicado en: Journal of Cell Science, Edición 24 issues a year, 2021, ISSN 1477-9137
Editor: The Company of Biologists
DOI: 10.1242/jcs.258462

p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation

Autores: Lopresti L, Capitani N, Tatangelo V, Boncompagni G, Frezzato F, Visentin A, Marotta G, Gozzetti A, Bocchia M, Trentin L, Baldari CT, Patrussi L
Publicado en: Frontiers in cell and developmental biology, Edición 12, 2024, Página(s) 1297116, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2024.1297116

Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics

Autores: Zevolini F, Onnis A, Khazen R, Mueller S, Marotta G, Valitutti S, Finetti F, Baldari CT
Publicado en: J Cell Sci, Edición 137, 2024, Página(s) jcs261476, ISSN 1477-9137
Editor: The Company of Biologists
DOI: 10.1242/jcs.261476

Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse

Autores: Audun Kvalvaag; Salvatore Valvo; Pablo F Céspedes; David G Saliba; Elke Kurz; Kseniya Korobchevskaya; Michael L Dustin
Publicado en: Proceedings of the National Academy of Sciences (PNAS), Edición 1, 2023, ISSN 1091-6490
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2211368120

Book chapters (3)

Exploiting the RUSH System to Study Lytic Granule Biogenesis in Cytotoxic T Lymphocytes

Autores: Nagaja Capitani; Chiara Cassioli; Keerthana Ravichandran; Cosima Tatiana Baldari
Publicado en: Methods in Molecular Biology, 2023, ISBN 978-1-0716-3135-5
Editor: Humana, New York, NY
DOI: 10.1007/978-1-0716-3135-5_27

Separation of Single Core and Multicore Lytic Granules by Subcellular Fractionation and Immunoisolation

Autores: Claudia Schirra; Nadia Alawar; Ute Becherer; Hsin-Fang Chang
Publicado en: Methods in Molecular Biology, 2023, ISBN 978-1-0716-3135-5
Editor: Humana, New York, NY
DOI: 10.1007/978-1-0716-3135-5_11

Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse

Autores: Sabina Müller; Liza Filali; Marie-Pierre Puissegur; Salvatore Valitutti
Publicado en: Methods in Molecular Biology, 2023, ISBN 978-1-0716-3135-5
Editor: Humana, New York, NY
DOI: 10.1007/978-1-0716-3135-5_30

Non-peer reviewed articles (1)

Kartezio: Evolutionary Design of Explainable Pipelines for Biomedical Image Analysis

Autores: Cortacero, Kévin; McKenzie, Brienne; Müller, Sabina; Khazen, Roxana; Lafouresse, Fanny; Corsaut, Gaëlle; Van Acker, Nathalie; Frenois, François-Xavier; Lamant, Laurence; Meyer, Nicolas; Vergier, Béatrice; Wilson, Dennis G.; Luga, Hervé; Staufer, Oskar; Dustin, Michael L.; Valitutti, Salvatore; Cussat-Blanc, Sylvain
Publicado en: arXiv, 2023, ISSN 2331-8422
Editor: Cornell University
DOI: 10.48550/arxiv.2302.14762