Analysis of the T cell’s Tactical Arsenal for Cancer Killing

Lytic granule exocytosis at immune synapses: lessons from neuronal synapses

Autori: Hsin-Fang Chang; Claudia Schirra; Varsha Pattu; Elmar Krause; Ute Becherer
Pubblicato in: Frontiers in Immunology, 2023, ISSN 1664-3224
Editore: Frontiers Media S.A
DOI: 10.3389/fimmu.2023.1177670

Greek Fire, Poison Arrows, and Scorpion Bombs: How Tumor Cells Defend Against the Siege Weapons of Cytotoxic T Lymphocytes

Autori: McKenzie B, Khazen R, Valitutti S
Pubblicato in: Frontiers in Immunology, Numero 16643224, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.894306

Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)

Autori: Chiara Cassioli; Laura Patrussi; Salvatore Valitutti; Cosima T. Baldari
Pubblicato in: International Journal of Molecular Sciences, Numero Monthly, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232214255

Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation

Autori: Kristina Zec, Barbora Schonfeldova, Zhichao Ai, Erinke Van Grinsven, Gabriela Pirgova, Hayley L. Eames, Dorothée L. Berthold, Moustafa Attar, Ewoud B. Compeer, Tal I. Arnon, Irina A. Udalova
Pubblicato in: Journal of Experimental Medicine, Numero 220, 2023, Pagina/e e20220595., ISSN 1540-9538
Editore: Rockefeller University Press
DOI: 10.1084/jem.20220595

The Expanding Arsenal of Cytotoxic T Cells

Autori: Chiara Cassioli, Cosima Tatiana Baldari
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.883010

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Autori: Hsin-Fang Chang; Claudia Schirra; Momchil Ninov; Ulrike Hahn; Keerthana Ravichandran; Elmar Krause; Ute Becherer; Štefan Bálint; Maria Harkiolaki; Henning Urlaub; Salvatore Valitutti; Cosima T. Baldari; Michael L. Dustin; Reinhard Jahn; Jens Rettig
Pubblicato in: Nature Communications, Numero 20411723, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28596-y

Comparison of different methods for isolating CD8+ T lymphocyte-derived extracellular vesicles and supramolecular attack particles

Autori: Ashwin K. Jainarayanan, Jesusa Capera, Pablo F. Céspedes, Mariana Conceição, Mirudula Elanchezhian, Tom Thomas, Scott Bonner, Salvatore Valvo, Elke Kurz, Ranjeet Singh Mahla, Georgina Berridge, Svenja Hester, Roman Fischer, Lynn B. Dustin, Matthew J. A. Wood, Michael L. Dustin
Pubblicato in: Journal of Extracellular Biology, Numero 2, 2023, ISSN 2768-2811
Editore: International Society for Extracellular Vesicles
DOI: 10.1002/jex2.74

A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

Autori: Nagaja Capitani; Anna Onnis; Francesca Finetti; Chiara Cassioli; Alessandro Plebani; Jlenia Brunetti; Arianna Troilo; Sofia D'Elios; Manuela Baronio; Luisa Gazzurelli; Chiara Della Bella; Daniel D Billadeau; Mario Milco D'Elios; Vassilios Lougaris; Cosima T Baldari
Pubblicato in: Cell Death & Differentiation, 2022, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-021-00837-5

Emerging roles of SARS-CoV-2 Spike/ACE2 in immune evasion and pathogenesis

Autori: Cosima T. Baldari; Anna Onnis; Emanuele Andreano; Giuseppe Del Giudice; Rino Rappuoli
Pubblicato in: Trends in Immunology, Numero 44, 2023, Pagina/e 424-434, ISSN 1471-4981
Editore: Elsevier Ltd
DOI: 10.1016/j.it.2023.04.001

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK3 activation and PD-1 expression

Autori: Montecchi T, Nannini G, De Tommaso D, Cassioli C, Monaci S, Coppola F, Ringressi Mn, Naldini A, Taddei A, Marotta G, Amedei A, Baldari CT, Ulivieri C
Pubblicato in: Cancer Immunology, Immunotherapy, Numero 73, 2024, Pagina/e 2, ISSN 1432-0851
Editore: Springer
DOI: 10.1007/s00262-023-03614-0

A solution for highly efficient electroporation of primary cytotoxic T lymphocytes

Autori: Alawar N, Schirra C, Hohmann M, Becherer U
Pubblicato in: BMC Biotechnology, Numero 24, 2024, Pagina/e 16, ISSN 1472-6750
Editore: BioMed Central
DOI: 10.1186/s12896-024-00839-4

IFT20: An Eclectic Regulator of Cellular Processes beyond Intraflagellar Transport.

Autori: Francesca Finetti; Anna Onnis; Cosima T. Baldari
Pubblicato in: International Journal of Molecular Science, Numero Monthly, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232012147

p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-κB

Autori: Tatangelo V, Boncompagni G, Capitani N, Lopresti L, Manganaro N, Frezzato F, Visentin A, Trentin L, Baldari CT, Patrussi L
Pubblicato in: Frontiers in Oncology, Numero 12, 2022, Pagina/e 877495, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.877495

Lymphocyte Polarization During Immune Synapse Assembly: Centrosomal Actin Joins the Game

Autori: Chiara Cassioli; Cosima T. Baldari
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.830835

SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

Autori: Anna Onnis; Emanuele Andreano; Chiara Cassioli; Francesca Finetti; Chiara Della Bella; Oskar Staufer; Elisa Pantano; Valentina Abbiento; Giuseppe Marotta; Mario Milco D’Elios; Rino Rappuoli; Cosima T. Baldari
Pubblicato in: Journal of Experimental Medicine, Numero Monthly, 2023, ISSN 1540-9538
Editore: Rockefeller University Press
DOI: 10.1084/jem.20220906

Ultra-rapid lytic granule release from CTL activates Ca2+-dependent synaptic resistance pathways in melanoma cell

Autori: Liza Filali; Marie-Pierre Puissegur; Kevin Cortacero; Sylvain Cussat-Blanc; Roxana Khazen; Nathalie Van Acker; François-Xavier Frenois, Arnaud Abreu; Laurence Lamant; Nicolas Meyer, Béatrice Vergier; Sabina Müller; Brienne McKenzie; Salvatore Valitutti
Pubblicato in: Science Advances, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abk3234

Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia

Autori: Boncompagni G, Tatangelo V, Lopresti L, Ulivieri C, Capitani N, Tangredi C, Marotta G, Frezzato F, Visentin A, Ciofini S, Gozzetti A, Calzada-Fraile D, Martin Cofreces NB, Trentin L, Patrussi L, Baldari CT
Pubblicato in: Cell Death & Disease, Numero 15, 2024, Pagina/e 144, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-024-06528-6

Resisting T cell attack: tumor-cell-intrinsic defense and reparation mechanisms

Autori: Brienne McKenzie, Salvatore Valitutti
Pubblicato in: Trends in Cancer, Numero 9, 2023, Pagina/e 198-211, ISSN 2405-8033
Editore: Elsevier Inc.
DOI: 10.1016/j.trecan.2022.12.003

The Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens

Autori: Nagaja Capitani; Cosima Tatiana Baldari
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.943344

Increasing LFA-1 Expression Enhances Immune Synapse Architecture and T Cell Receptor Signaling in Jurkat E6.1 Cells

Autori: Chiara Cassioli; Stefan Balint; Ewoud B Compeer; James H Felce; Alessandra Gamberucci; Chiara Della Bella; Suet Ling Felce; Jlenia Brunetti; Salvatore Valvo; Daniela Pende; Mario M D’Elios; Lorenzo Moretta; Michael L Dustin; Cosima T Baldari
Pubblicato in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.673446

Evolutionary design of explainable algorithms for biomedical image segmentation

Autori: Cortacero K, McKenzie B, Müller S, Khazen R, Lafouresse F, Corsaut G, Van Acker N, Frenois F-X, Lamant L, Meyer N, Vergier B, Wilson DG, Luga H, Staufer S, Dustin ML, Valitutti S, Cussat-Blanc S
Pubblicato in: Nature Communications, Numero 14, 2023, Pagina/e 7112, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-42664-x

The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly

Autori: Chiara Cassioli; Anna Onnis; Francesca Finetti; Nagaja Capitani; Jlenia Brunetti; Ewoud B Compeer; Veronika Niederlova; Ondrej Stepanek; Michael L Dustin; Cosima T Baldari
Pubblicato in: Journal of Cell Science, Numero 24 issues a year, 2021, ISSN 1477-9137
Editore: The Company of Biologists
DOI: 10.1242/jcs.258462

p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation

Autori: Lopresti L, Capitani N, Tatangelo V, Boncompagni G, Frezzato F, Visentin A, Marotta G, Gozzetti A, Bocchia M, Trentin L, Baldari CT, Patrussi L
Pubblicato in: Frontiers in cell and developmental biology, Numero 12, 2024, Pagina/e 1297116, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2024.1297116

Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics

Autori: Zevolini F, Onnis A, Khazen R, Mueller S, Marotta G, Valitutti S, Finetti F, Baldari CT
Pubblicato in: J Cell Sci, Numero 137, 2024, Pagina/e jcs261476, ISSN 1477-9137
Editore: The Company of Biologists
DOI: 10.1242/jcs.261476

Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse

Autori: Audun Kvalvaag; Salvatore Valvo; Pablo F Céspedes; David G Saliba; Elke Kurz; Kseniya Korobchevskaya; Michael L Dustin
Pubblicato in: Proceedings of the National Academy of Sciences (PNAS), Numero 1, 2023, ISSN 1091-6490
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2211368120

Exploiting the RUSH System to Study Lytic Granule Biogenesis in Cytotoxic T Lymphocytes

Autori: Nagaja Capitani; Chiara Cassioli; Keerthana Ravichandran; Cosima Tatiana Baldari
Pubblicato in: Methods in Molecular Biology, 2023, ISBN 978-1-0716-3135-5
Editore: Humana, New York, NY
DOI: 10.1007/978-1-0716-3135-5_27

Separation of Single Core and Multicore Lytic Granules by Subcellular Fractionation and Immunoisolation

Autori: Claudia Schirra; Nadia Alawar; Ute Becherer; Hsin-Fang Chang
Pubblicato in: Methods in Molecular Biology, 2023, ISBN 978-1-0716-3135-5
Editore: Humana, New York, NY
DOI: 10.1007/978-1-0716-3135-5_11

Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse

Autori: Sabina Müller; Liza Filali; Marie-Pierre Puissegur; Salvatore Valitutti
Pubblicato in: Methods in Molecular Biology, 2023, ISBN 978-1-0716-3135-5
Editore: Humana, New York, NY
DOI: 10.1007/978-1-0716-3135-5_30

Kartezio: Evolutionary Design of Explainable Pipelines for Biomedical Image Analysis

Autori: Cortacero, Kévin; McKenzie, Brienne; Müller, Sabina; Khazen, Roxana; Lafouresse, Fanny; Corsaut, Gaëlle; Van Acker, Nathalie; Frenois, François-Xavier; Lamant, Laurence; Meyer, Nicolas; Vergier, Béatrice; Wilson, Dennis G.; Luga, Hervé; Staufer, Oskar; Dustin, Michael L.; Valitutti, Salvatore; Cussat-Blanc, Sylvain
Pubblicato in: arXiv, 2023, ISSN 2331-8422
Editore: Cornell University
DOI: 10.48550/arxiv.2302.14762

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