Integration of the Biochemical and Mechanical Networks of Cell Division

Información del proyecto

BIOMECANET

Identificador del acuerdo de subvención: 951430

DOI

10.3030/951430

Fecha de la firma de la CE 4 Febrero 2021

Fecha de inicio 1 Julio 2021

Fecha de finalización 30 Junio 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 10 613 236,00

Aportación de la UE

€ 10 613 236,00

Coordinado por

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (22)

Regulation of minimal spindle midzone organization by mitotic kinases

Autores: Wei Ming Lim, Wei-Xiang Chew, Arianna Esposito Verza, Marion Pesenti, Andrea Musacchio, Thomas Surrey
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-53500-1

Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

Autores: Pim J. Huis in 't Veld; Sabine Wohlgemuth; Carolin Koerner; Franziska Müller; Petra Janning; Andrea Musacchio
Publicado en: Protein Science, 2021, ISSN 0961-8368
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4233

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation

Autores: Cláudia Brito; Marina Serna; Pablo Guerra; Oscar Llorca; Thomas Surrey
Publicado en: Science, 2024, ISSN 1095-9203
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adk6160

The minus-end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules

Autores: Gil Henkin; Cláudia Brito; Claire Thomas; Thomas Surrey
Publicado en: J Cell Biol, 2023, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202304020

NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends

Autores: Sabina Colombo, Christel Michel, Silvia Speroni, Felix Ruhnow, Maria Gili, Claudia Brito, Thomas Surrey
Publicado en: J Cell Biol, 2025, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1101/2024.08.30.610456

Hydrolysis-deficient mosaic microtubules as faithful mimics of the GTP cap

Autores: Juan Estévez-Gallego, Thorsten B. Blum, Felix Ruhnow, María Gili, Silvia Speroni, Raquel García-Castellanos, Michel O. Steinmetz, Thomas Surrey
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-57555-6

Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

Autores: Marion E. Pesenti; Tobias Raisch; Duccio Conti; Ingrid Hoffmann; Dorothee Vogt; Daniel Prumbaum; Ingrid R. Vetter; Stefan Raunser; Andrea Musacchio
Publicado en: Molecular Cell, 2022, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2022.04.027

Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores

Autores: Tobias Raisch; Giuseppe Ciossani; Ennio d’Amico; Verena Cmentowski; Sara Carmignani; Stefano Maffini; Felipe Merino; Sabine Wohlgemuth; Ingrid R Vetter; Stefan Raunser; Andrea Musacchio
Publicado en: EMBO J, 2022, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2021110411

A typical workflow to simulate cytoskeletal systems with Cytosim

Autores: Lugo, Carlos A.; Saikia, Eashan; Nedelec, Francois
Publicado en: Journal of visualed experiments, Edición 12, 2023, Página(s) 1-22, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.48550/arxiv.2205.13852

Structure of the human KMN complex and implications for regulation of its assembly

Autores: Soumitra Polley, Tobias Raisch, Sabrina Ghetti, Marie Körner, Melina Terbeck, Frauke Gräter, Stefan Raunser, Camilo Aponte-Santamaría, Ingrid R. Vetter, Andrea Musacchio
Publicado en: Nature Structural & Molecular Biology, Edición 31, 2024, Página(s) 861-873, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-024-01230-9

Crosslinker design determines microtubule network organization by opposing motors

Autores: Gil Henkin; Wei-Xiang Chew; François Nédélec; Thomas Surrey
Publicado en: PNAS, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2206398119

<i>In vitro</i> reconstitution of a minimal human centrosome scaffold capable of forming and clustering microtubule asters

Autores: Manolo U. Rios, Weronika E. Stachera, Nicole E. Familiari, Claudia Brito, Thomas Surrey, Jeffrey B. Woodruff
Publicado en: Journal of Cell Science, Edición 138, 2025, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.264121

On the role of phase separation in the biogenesis of membraneless compartments

Autores: A Musacchio
Publicado en: EMBO J., 2022, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2021109952

RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona

Autores: Verena Cmentowski; Giuseppe Ciossani; Ennio d'Amico; Sabine Wohlgemuth; Mikito Owa; Brian Dynlacht; Andrea Musacchio
Publicado en: EMBO J, 2023, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2023114838

Branched microtubule nucleation and dynein transport organize RanGTP asters in <i>Xenopus laevis</i> egg extract

Autores: Scrofani, Jacopo, 1984-; Ruhnow, Felix; Chew, Wei-Xiang; Normanno, Davide; Nédélec, François; Surrey, Thomas; Vernos, Isabelle, 1959-
Publicado en: MBoC, 2024, ISSN 1939-4586
Editor: American Society for Cell Biology
DOI: 10.1091/mbc.e23-10-0407

Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin

Autores: Ennio A. d’Amico; Misbha Ud Din Ahmad; Verena Cmentowski; Mathias Girbig; Franziska Müller; Sabine Wohlgemuth; Andreas Brockmeyer; Stefano Maffini; Petra Janning; Ingrid R. Vetter; Andrew P. Carter; Anastassis Perrakis; Andrea Musacchio
Publicado en: J Cell Biol, 2022, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202206131

Effects of microtubule length and crowding on active microtubule network organization

Autores: Wei-Xiang Chew; Gil Henkin; François Nédélec; Thomas Surrey
Publicado en: iScience, 2023, ISSN 2589-0042
Editor: Elsevier Inc.
DOI: 10.1016/j.isci.2023.106063

Molecular design principles for bipolar spindle organization by two opposing motors

Autores: Wei-Xiang Chew, François Nédélec, Thomas Surrey
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2422190122

Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding

Autores: Soumitra Polley; Helen Müschenborn; Melina Terbeck; Anna De Antoni; Ingrid R Vetter; Marileen Dogterom; Andrea Musacchio; Vladimir A Volkov; Pim J Huis in’t Veld
Publicado en: EMBO J, 2023, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2022112504

Microtubule binding of the human augmin complex is directly controlled by importins and Ran-GTP

Autores: Kseniya Ustinova; Felix Ruhnow; Maria Gili; Thomas Surrey
Publicado en: J Cell Sci., 2023, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.261096

Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin

Autores: Gil Henkin, Cláudia Brito, Andreas Plückthun, Thomas Surrey
Publicado en: BIO-PROTOCOL, Edición 14, 2024, ISSN 2331-8325
Editor: Bio-Protocol, LLC
DOI: 10.21769/bioprotoc.5109

The cell cycle controls spindle architecture in Arabidopsis by activating the augmin pathway

Autores: Mariana Romeiro Motta, François Nédélec, Helen Saville, Elke Woelken, Claire Jacquerie, Martine Pastuglia, Sara Christina Stolze, Eveline Van De Slijke, Lev Böttger, Katia Belcram, Hirofumi Nakagami, Geert De Jaeger, David Bouchez, Arp Schnittger
Publicado en: Developmental Cell, Edición 59, 2024, Página(s) 2947-2961.e9, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2024.08.001