Integration of the Biochemical and Mechanical Networks of Cell Division

Project Information

BIOMECANET

Grant agreement ID: 951430

DOI

10.3030/951430

EC signature date 4 February 2021

Start date 1 July 2021

End date 30 June 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 10 613 236,00

EU contribution

€ 10 613 236,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Regulation of minimal spindle midzone organization by mitotic kinases

Author(s): Wei Ming Lim, Wei-Xiang Chew, Arianna Esposito Verza, Marion Pesenti, Andrea Musacchio, Thomas Surrey
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53500-1

Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

Author(s): Pim J. Huis in 't Veld; Sabine Wohlgemuth; Carolin Koerner; Franziska Müller; Petra Janning; Andrea Musacchio
Published in: Protein Science, 2021, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4233

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation

Author(s): Cláudia Brito; Marina Serna; Pablo Guerra; Oscar Llorca; Thomas Surrey
Published in: Science, 2024, ISSN 1095-9203
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adk6160

The minus-end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules

Author(s): Gil Henkin; Cláudia Brito; Claire Thomas; Thomas Surrey
Published in: J Cell Biol, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202304020

NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends

Author(s): Sabina Colombo, Christel Michel, Silvia Speroni, Felix Ruhnow, Maria Gili, Claudia Brito, Thomas Surrey
Published in: J Cell Biol, 2025, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1101/2024.08.30.610456

Hydrolysis-deficient mosaic microtubules as faithful mimics of the GTP cap

Author(s): Juan Estévez-Gallego, Thorsten B. Blum, Felix Ruhnow, María Gili, Silvia Speroni, Raquel García-Castellanos, Michel O. Steinmetz, Thomas Surrey
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-57555-6

Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

Author(s): Marion E. Pesenti; Tobias Raisch; Duccio Conti; Ingrid Hoffmann; Dorothee Vogt; Daniel Prumbaum; Ingrid R. Vetter; Stefan Raunser; Andrea Musacchio
Published in: Molecular Cell, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.04.027

Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores

Author(s): Tobias Raisch; Giuseppe Ciossani; Ennio d’Amico; Verena Cmentowski; Sara Carmignani; Stefano Maffini; Felipe Merino; Sabine Wohlgemuth; Ingrid R Vetter; Stefan Raunser; Andrea Musacchio
Published in: EMBO J, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021110411

A typical workflow to simulate cytoskeletal systems with Cytosim

Author(s): Lugo, Carlos A.; Saikia, Eashan; Nedelec, Francois
Published in: Journal of visualed experiments, Issue 12, 2023, Page(s) 1-22, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.48550/arxiv.2205.13852

Structure of the human KMN complex and implications for regulation of its assembly

Author(s): Soumitra Polley, Tobias Raisch, Sabrina Ghetti, Marie Körner, Melina Terbeck, Frauke Gräter, Stefan Raunser, Camilo Aponte-Santamaría, Ingrid R. Vetter, Andrea Musacchio
Published in: Nature Structural & Molecular Biology, Issue 31, 2024, Page(s) 861-873, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-024-01230-9

Crosslinker design determines microtubule network organization by opposing motors

Author(s): Gil Henkin; Wei-Xiang Chew; François Nédélec; Thomas Surrey
Published in: PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2206398119

<i>In vitro</i> reconstitution of a minimal human centrosome scaffold capable of forming and clustering microtubule asters

Author(s): Manolo U. Rios, Weronika E. Stachera, Nicole E. Familiari, Claudia Brito, Thomas Surrey, Jeffrey B. Woodruff
Published in: Journal of Cell Science, Issue 138, 2025, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.264121

On the role of phase separation in the biogenesis of membraneless compartments

Author(s): A Musacchio
Published in: EMBO J., 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021109952

RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona

Author(s): Verena Cmentowski; Giuseppe Ciossani; Ennio d'Amico; Sabine Wohlgemuth; Mikito Owa; Brian Dynlacht; Andrea Musacchio
Published in: EMBO J, 2023, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2023114838

Branched microtubule nucleation and dynein transport organize RanGTP asters in <i>Xenopus laevis</i> egg extract

Author(s): Scrofani, Jacopo, 1984-; Ruhnow, Felix; Chew, Wei-Xiang; Normanno, Davide; Nédélec, François; Surrey, Thomas; Vernos, Isabelle, 1959-
Published in: MBoC, 2024, ISSN 1939-4586
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e23-10-0407

Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin

Author(s): Ennio A. d’Amico; Misbha Ud Din Ahmad; Verena Cmentowski; Mathias Girbig; Franziska Müller; Sabine Wohlgemuth; Andreas Brockmeyer; Stefano Maffini; Petra Janning; Ingrid R. Vetter; Andrew P. Carter; Anastassis Perrakis; Andrea Musacchio
Published in: J Cell Biol, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202206131

Effects of microtubule length and crowding on active microtubule network organization

Author(s): Wei-Xiang Chew; Gil Henkin; François Nédélec; Thomas Surrey
Published in: iScience, 2023, ISSN 2589-0042
Publisher: Elsevier Inc.
DOI: 10.1016/j.isci.2023.106063

Molecular design principles for bipolar spindle organization by two opposing motors

Author(s): Wei-Xiang Chew, François Nédélec, Thomas Surrey
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2422190122

Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding

Author(s): Soumitra Polley; Helen Müschenborn; Melina Terbeck; Anna De Antoni; Ingrid R Vetter; Marileen Dogterom; Andrea Musacchio; Vladimir A Volkov; Pim J Huis in’t Veld
Published in: EMBO J, 2023, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022112504

Microtubule binding of the human augmin complex is directly controlled by importins and Ran-GTP

Author(s): Kseniya Ustinova; Felix Ruhnow; Maria Gili; Thomas Surrey
Published in: J Cell Sci., 2023, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.261096

Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin

Author(s): Gil Henkin, Cláudia Brito, Andreas Plückthun, Thomas Surrey
Published in: BIO-PROTOCOL, Issue 14, 2024, ISSN 2331-8325
Publisher: Bio-Protocol, LLC
DOI: 10.21769/bioprotoc.5109

The cell cycle controls spindle architecture in Arabidopsis by activating the augmin pathway

Author(s): Mariana Romeiro Motta, François Nédélec, Helen Saville, Elke Woelken, Claire Jacquerie, Martine Pastuglia, Sara Christina Stolze, Eveline Van De Slijke, Lev Böttger, Katia Belcram, Hirofumi Nakagami, Geert De Jaeger, David Bouchez, Arp Schnittger
Published in: Developmental Cell, Issue 59, 2024, Page(s) 2947-2961.e9, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.08.001