Descripción del proyecto
Nanopartículas con una superficie biogénica
Las vesículas extracelulares (VE) son las lanzaderas universales de la comunicación intercelular, que transfieren lípidos, proteínas y ácidos nucleicos, median procesos naturales y propagan distintas enfermedades, como el cáncer y las infecciones. El principal objetivo del proyecto BOW, financiado con fondos europeos, es estudiar y desarrollar la tecnología capaz de dotar de las capacidades de precisión, circulación y especificidad de la superficie biológica de las VE a nanodispositivos superparamagnéticos recubriéndolos con una membrana de VE simple o de varias capas. Esta tecnología tiene por objeto hacer avanzar nanodispositivos implantables y nanomateriales hacia la producción sostenible y la traducción clínica, y demostrar así la posibilidad de sintetizar funciones biomiméticas en cualquier nanodispositivo artificial.
Objetivo
Extracellular vesicle (EVs) nanoparticles are the universal agents of intercellular and inter-organismal communication “made by cells for cells” to shuttle lipids, proteins and nucleic acids, EVs mediate physiological processes and help to spread various diseases, including cancer and infections. Their innate navigation performances take origin in the unique structure and composition of their membrane (which is to date inaccessible to synthetic mimics). The main goal of the BOW project is to explore and consolidate the technology able to impart biological surface precision, circulation and targeting abilities of EVs to superparamagnetic nanodevices (Magnetic Bead Devices, MBDs) by “dressing” them with a single- or multi-layer “wetsuit” of EV membrane “fabric”. This will proof and set a general, viable paradigm to recapitulate key biomimetic functions – including camouflage to the immune system and organ site/tumor targeting – to any synthetic nanodevice, while being disruptive as a first example of biogenic nanotechnology. If successful, such a non-incremental technology will promote the progress of implantable nanodevices and nanomaterials towards sustainable production and clinical translation, contributing to strengthen and keep in the lead position European biotechnology and impacting life quality for people. Major objectives include: (i) production high-grade EVs with biomimetic and organotropic functions, (ii) synthesis and functionalization of MBDs, (iii) engineering a microfluidic device for streamlined fabrication of EV membrane coated MBDs (evMBDs) (iv) evaluation of evMBD biological performances and nanotoxiciy in-vitro, ex-vivo and in-vivo. BOW will be made possible thanks to a balanced ecology-biology-biophysics-chemistry-engineering matrix, of well-established and internationally recognized academics (7), high biotech SMEs (3), plus 1 innovation consulting, contributing to strengthen European pool of expertise and biotechnology innovation eco-system.
Ámbito científico
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencescell biology
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- social scienceseconomics and businesseconomicssustainable economy
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-EIC-FETPROACT-2019
Régimen de financiación
RIA - Research and Innovation actionCoordinador
50019 Firenze
Italia