Project description
Molecular biology collaboration to tackle late-onset diseases
Age-related diseases such as cancer and neurodegenerative disorders have become a public concern in Europe today due to the ageing population. The field of molecular biology is very promising for shedding light on late-onset diseases with a focus on incapacitating, age-related conditions. Portugal’s Instituto de Biologia Molecular e Celular (IBMC/i3S) has attracted international attention for its work in this domain. However, its scientists need to increase their competitivity in systems biology, bioinformatics and advanced biophysics. The EU-funded PhasAGE project will organise practical courses at the IBMC/i3S to offer the available knowledge in the field of phase transitions in ageing and age-related disorders. A unique collaborative network will be established between the IBMC/i3S, the Universities of Padua and Barcelona and the Vlaams Instituut voor Biotechnologie. Moreover, a European excellence hub will contribute to research and teaching quality.
Objective
The percentage of elderly population in Portugal and Europe is in rapid expansion raising a pressing concern for the increase of seriously incapacitating age-related diseases.
The Twining proposal PhasAGE aims specifically at strengthening the excellence, knowledge and innovation potential of its coordinating institution - Instituto de Biologia Molecular e Celular (IBMC/i3S) - in the emerging field of biomolecular phase transitions in age-related diseases.
The coordinating institution has been increasing its international visibility, and is approaching excellence in different aspects of cell and molecular biology applied to late-onset diseases, with a focus on cancer and neurodegenerative disorders.
However, IBMC/i3S researchers are lagging behind, losing their potential and external opportunities for being more competitive in different aspects of systems biology, bioinformatics and advanced biophysics, competences that are unquestionably required for complementing ongoing research and systematically exploring macromolecular assembly and phase transitions in health and their de-regulation in age-related disorders.
By establishing a sustainable and unique collaborative network between IBMC/i3S and the University of Padova (UNIPD, IT), the Autonomous University of Barcelona (UAB, ES) and the Vlaams Instituut voor Biotechnologie (VIB, BE), PhasAGE will primarily enhance the impact and quality of research and training at IBMC/i3S on computational and experimental analysis of protein phase separation. It will contribute to overcome the European fragmentation in this field and to the creation of a European excellence hub at IBMC/i3S, while raising the research and teaching profile of all Partners’ staff. PhasAGE will also foster the development and implementation of novel tools and technologies, while contributing towards a more responsible and intensive science communication and outreach scientific literacy with societal impact.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biophysics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.4.b. - Twinning of research institutions
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
CSA - Coordination and support action
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-WIDESPREAD-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4200 135 Porto
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.