Project description DEENESFRITPL Molecular biology collaboration to tackle late-onset diseases Age-related diseases such as cancer and neurodegenerative disorders have become a public concern in Europe today due to the ageing population. The field of molecular biology is very promising for shedding light on late-onset diseases with a focus on incapacitating, age-related conditions. Portugal’s Instituto de Biologia Molecular e Celular (IBMC/i3S) has attracted international attention for its work in this domain. However, its scientists need to increase their competitivity in systems biology, bioinformatics and advanced biophysics. The EU-funded PhasAGE project will organise practical courses at the IBMC/i3S to offer the available knowledge in the field of phase transitions in ageing and age-related disorders. A unique collaborative network will be established between the IBMC/i3S, the Universities of Padua and Barcelona and the Vlaams Instituut voor Biotechnologie. Moreover, a European excellence hub will contribute to research and teaching quality. Show the project objective Hide the project objective Objective The percentage of elderly population in Portugal and Europe is in rapid expansion raising a pressing concern for the increase of seriously incapacitating age-related diseases. The Twining proposal PhasAGE aims specifically at strengthening the excellence, knowledge and innovation potential of its coordinating institution - Instituto de Biologia Molecular e Celular (IBMC/i3S) - in the emerging field of biomolecular phase transitions in age-related diseases. The coordinating institution has been increasing its international visibility, and is approaching excellence in different aspects of cell and molecular biology applied to late-onset diseases, with a focus on cancer and neurodegenerative disorders. However, IBMC/i3S researchers are lagging behind, losing their potential and external opportunities for being more competitive in different aspects of systems biology, bioinformatics and advanced biophysics, competences that are unquestionably required for complementing ongoing research and systematically exploring macromolecular assembly and phase transitions in health and their de-regulation in age-related disorders. By establishing a sustainable and unique collaborative network between IBMC/i3S and the University of Padova (UNIPD, IT), the Autonomous University of Barcelona (UAB, ES) and the Vlaams Instituut voor Biotechnologie (VIB, BE), PhasAGE will primarily enhance the impact and quality of research and training at IBMC/i3S on computational and experimental analysis of protein phase separation. It will contribute to overcome the European fragmentation in this field and to the creation of a European excellence hub at IBMC/i3S, while raising the research and teaching profile of all Partners’ staff. PhasAGE will also foster the development and implementation of novel tools and technologies, while contributing towards a more responsible and intensive science communication and outreach scientific literacy with societal impact. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesbiophysicsnatural sciencesbiological sciencesmolecular biology Keywords Computational Biology Biophysics Cell Biology Intrinsically-disordered proteins Late-onset diseases Biomolecular phase separation Aging Age-related diseases Programme(s) H2020-EU.4.b. - Twinning of research institutions Main Programme Topic(s) WIDESPREAD-05-2020 - Twinning Call for proposal H2020-WIDESPREAD-2018-2020 See other projects for this call Sub call H2020-WIDESPREAD-2020-5 Funding Scheme CSA - Coordination and support action Coordinator INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Net EU contribution € 522 991,25 Address RUA ALFREDO ALLEN 208 4200 135 Porto Portugal See on map Region Continente Norte Área Metropolitana do Porto Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 522 991,25 Participants (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI PADOVA Italy Net EU contribution € 122 500,00 Address VIA 8 FEBBRAIO 2 35122 Padova See on map Region Nord-Est Veneto Padova Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 122 500,00 UNIVERSITAT AUTONOMA DE BARCELONA Spain Net EU contribution € 117 500,00 Address EDIF A CAMPUS DE LA UAB BELLATERRA CERDANYOLA V 08193 Cerdanyola Del Valles See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 117 500,00 VIB VZW Belgium Net EU contribution € 136 750,00 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 136 750,00
