Koç University Transplant Immunology Research Center of Excellence

Livrables

Set up and specifications of the Corporate Affiliates Program

Delivery of the Corporate Affiliates Program that will engage relevant industry actors in working together with the Transplant Immunology Lab researchers towards establishing common collaboration paths, joint R&D initiatives, and in support of application-driven research through the translation of the Lab’s research results to new products/services.

Final Version of the Training Plan
Innovative Doctoral Training at the KU SoM

Task 5.2. actions will be reported by M24, and progress on the implementation of the PhD programme will be reported in in M42 and M60.

Requirements, preparations and advertisement of the ERA Chair team job positions

Requirements, preparations and advertisement of the ERA Chair team job positions will be planned.

Selection and recruitment of the ERA Chair team members

Report on the selection and recruitment of the ERA Chair team members.

Set up of the Industrial and Governmental Advisory Board

Delivery of the board with the participation of national and international actors from the business and policy sectors. Initial members will be representatives from the Turkish industry and policy making level.

Plan for the structure of the ERA Chair team

Plan for the structure of the ERA Chair team will be prepared

Training Plan

A Training Plan that will be drafted by the ECH M12 updated in M36 will provide the necessary structure and content of the core training activities of the Centres researchers and KUs staff This plan will pay particular attention to the newly hired researchers by defining i A process for their orientation and integration in their new environment ii Mentoring and advisorsupport schemes for the researchers and especially younger personnel iii Specific personal career and development plans for the ERA Chair team researchers that will be codeveloped between the Labs employees and the ECH and updated throughout the project when necessary

Actions for building international relationships

Output of Task 5.3. actions will be reported in this document.

Set up and operation of the International Advisory Board

Early in the project and prior to the recruitment of the ECH the PM in cooperation with the SC will undertake the procedures in order to form the projects International Advisory Board IAB It will be composed of toplevel international scientists with vast expertise in the research area of the project holding an R4 or R3 level The IAB members will be selected based on a number of criteria ie expertise sector publications previous ECH positions etc and a shortlist invitation process see section 321 The specific Terms of Reference for its operation will be provided by M3 together with a report that will provide an overview of the scope structure operational management and expected contribution of the Board including a list and CVs of its members The principal role of the IAB will be to act as an independent validation and consultation body It will have a key role in the ECH recruitment process in evaluating the implementation of the required structural changes

Requirements, preparations and advertisement of the ECH position

Final definition of the ERA Chair Holder position requirements M1Development and release of the job vacancy advertisement M1

Scientific and Management Plan

SMP will offer directions for the set up and organization of the new Transplant Immunology Research Centre and Lab according to the ERA priorities In doing so the ECH will elaborate on hisher draft version of the SMP developed during hisher recruitment process It has to be underlined that the development of the SMP will also take into consideration i the national and European priorities ii the standards that the European Federation for Immunogenetics EFI sets for such laboratories iii the research capacity of other KU departments The SMP will define both Scientific Agenda and its Administrative and Organisational aspects Work will start with a thorough review of the existing KU departments and their research capacity A series of informal meetings between the ECH and the leaders and researchers of other KU research group is foreseen right after the hiring of the ECH These will put in place the required mechanisms so that the Lab is integrated naturally within an interdisciplinary platform of KUThe ECH will be supported by the entire project team as well as by the research leaders of all the identified synergetic KU research groups and the projects IAB On this basis and by leveraging the information from the abovementioned process the ECH will set up the Scientific Agenda research program of the new Lab Overall the Scientific Agenda will define the scientific orientation of the new Lab and elaborate on the research topics objectives and tasks that will be pursued The SMP will be developed by ECH in M7 and updated in M36 It will be dynamically updated to ensure the orientation of the group in line with research developments in the field

Publications

The balance between memory and regulatory cell populations in kidney transplant recipients with operational tolerance

Auteurs: Caner Süsal, Cristiam M Alvarez, Louise Benning, Volker Daniel, Martin Zeier, Matthias Schaier, Christian Morath, Claudius Speer
Publié dans: Clinical and Experimental Immunology, Numéro 216, 2024, Page(s) 318-330, ISSN 0009-9104
Éditeur: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxae018

Targeting IL-6 in antibody-mediated kidney transplant rejection

Auteurs: Mehmet Kanbay, Berk Mizrak, Sidar Copur, Ezgi N Alper, Sebahat Akgul, Alberto Ortiz, Caner Susal
Publié dans: Clinical Kidney Journal, Numéro 18, 2025, ISSN 2048-8505
Éditeur: Oxford University Press
DOI: 10.1093/ckj/sfaf108

Molecular HLA mismatching for prediction of primary humoral alloimmunity and graft function deterioration in paediatric kidney transplantation

Auteurs: Jon Jin Kim, Alexander Fichtner, Hannah C. Copley, Loren Gragert , Caner Süsal, Luca Dello Strologo, Jun Oh,Lars Pape, Lutz T. Weber , Marcus Weitz,Jens König, Kai Krupka, Burkhard Tönshoff and Vasilis Kosmoliaptsis
Publié dans: Frontiers in Immunology, Numéro Volume 14, 2023, Page(s) 1092335, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1092335

Differences in excess mortality by recipient sex after heart transplant: An Individual Patient Data Meta-Analysis

Auteurs: Amanda J. Vinson MD, MSc, Xun Zhang PhD, Mourad Dahhou MSc, Caner Süsal MD, Bernd Döhler PhD, Anette Melk MD, Ruth Sapir-Pichhadze MD, MSc, PhD, Heloise Cardinal MD, PhD, Germaine Wong MD, Anna Francis PhD, Helen Pilmore MD, Lauren T. Grinspan MD and Bethany J. Foster MD, MSc.
Publié dans: The Journal of Heart and Lung Transplantation, 2024, ISSN 1053-2498
Éditeur: Elsevier BV
DOI: 10.1016/j.healun.2024.03.016

Influence of donor sex and age on graft outcome in kidney transplantation

Auteurs: Anette Melk, Rizky I Sugianto, Xun Zhang, Mourad Dahhou, Bernd Döhler, Caner Süsal, Ruth Sapir-Pichhadze, Germaine Wong, Bethany J Foster
Publié dans: Nephrology Dialysis Transplantation, Numéro 39, 2024, Page(s) 607-617, ISSN 0931-0509
Éditeur: Oxford University Press
DOI: 10.1093/ndt/gfad181

Importance of Parental Consanguinity and Family History of Kidney Disease in the Turkish Adult Chronic Kidney Disease Population: An Epidemiologic Study

Auteurs: null null, Erol Demir, Yasar Caliskan, null null, Numune Aliyeva, null null, Ozlem Yilmaz, null null, Dilara Celik, null null, Sabahat Usta Akgul, null null, Aydin Turkmen, null null
Publié dans: Turkish Journal of Nephrology, Numéro 33, 2024, Page(s) 333-341, ISSN 2667-4440
Éditeur: Aves
DOI: 10.5152/turkjnephrol.2024.22442

Donor-Derived Cell-Free DNA (dd-cfDNA) in Kidney Transplant Recipients With Indication Biopsy—Results of a Prospective Single-Center Trial

Auteurs: Louise Benning , Christian Morath , Annette Fink , Markus Rudek , Claudius Speer , Florian Kälble , Christian Nusshag , Jörg Beimler , Constantin Schwab , Rüdiger Waldherr , Martin Zeier , Caner Süsal , and Thuong Hien Tran
Publié dans: Transplant International, Numéro Volume 36, 2023, Page(s) 11899, ISSN 0934-0874
Éditeur: Blackwell Publishing Inc.
DOI: 10.3389/ti.2023.11899

Corrigendum: Molecular HLA mismatching for prediction of primary humoral alloimmunity and graft function deterioration in paediatric kidney transplantation

Auteurs: Jon Jin Kim, Alexander Fichtner, Hannah C. Copley, Loren Gragert, Caner Süsal, Luca Dello Strologo, Jun Oh, Lars Pape, Lutz T. Weber, Marcus Weitz, Jens König, Kai Krupka, Burkhard Tönshoff, Vasilis Kosmoliaptsis
Publié dans: Frontiers in Immunology, Numéro 14, 2023, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1188527

Incidence, risk factors, management strategies, and outcomes of antibody-mediated rejection in pediatric kidney transplant recipients—a multicenter analysis of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN)

Auteurs: Alexander Fichtner, Laura Gauché, Caner Süsal, Thuong Hien Tran, Rüdiger Waldherr, Kai Krupka, Isabella Guzzo, Andrea Carraro, Jun Oh, Matthias Zirngibl, Marcus Weitz, Jens König, Anja Büscher, Laszlo Berta, Thomas Simon, Atif Awan, Krisztina Rusai, Rezan Topaloglu, Licia Peruzzi, Nikoleta Printza, Jon Jin Kim, Lutz T. Weber, Anette Melk, Lars Pape, Susanne Rieger, Christian Patry, Britta Hö
Publié dans: Pediatric Nephrology, 2024, ISSN 0931-041X
Éditeur: Springer Verlag
DOI: 10.1007/s00467-024-06487-2

Blood group-specific apheresis in combination with daratumumab as a rescue therapy of acute antibody-mediated rejection in a case of ABO- and human leukocyte antigen-incompatible kidney transplantation

Auteurs: Can C Süsal, Leonie Kraft, Andrea Ender, Caner Süsal, Amelie Schwenger, Kerstin Amann, Georg A Böhmig, and Vedat Schwenger Abstract
Publié dans: SAGE Open Medical Case Reports, Numéro Volume 11, 2023, ISSN 2050-313X
Éditeur: SAGE Publications Ltd
DOI: 10.1177/2050313x231211050

Summary Report of the CTS-TIREX Expert Meeting 2024 “Innovative Approaches to Immunogenetics and Organ Transplantation”

Auteurs: Caner Süsal, Idil Orhon, Georg A. Böhmig, Lionel Rostaing, Klemens Budde, Bariş Akin, Mehmet Kanbay, Burak Kocak, Thuong Hien Tran, Christian Morath
Publié dans: Transplantation, Numéro 109, 2025, Page(s) 1271-1273, ISSN 0041-1337
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000005430

The novel HLA-B*39:199 allele identified in a candidate bone marrow donor

Auteurs: Sebahat Usta Akgul , Talin Catalbasyan , Demir Kaan Demir , Mahdis Borjkhani , Caner Süsal
Publié dans: HLA, Numéro Volume 103, Numéro 2, 2024, Page(s) e15360, ISSN 2059-2302
Éditeur: John Wiley and Sons Inc
DOI: 10.1111/tan.15360

Imlifidase in kidney transplantation

Auteurs: Mehmet Kanbay, Sidar Copur, Mustafa Guldan, Ahmet U Topcu, Lasin Ozbek, Baris Hasbal, Caner Süsal, Burak Kocak, Jasper Callemeyn, Mårten Segelmark
Publié dans: Clinical Kidney Journal, Numéro Volume 17, Numéro 3, 2024, Page(s) sfae033, ISSN 2048-8505
Éditeur: Oxford University Press
DOI: 10.1093/ckj/sfae033

Outcome and Risk Factors for Mortality in Peritoneal Dialysis Patients: 22 Years of Experience in a Turkish Center

Auteurs: null null, Erol Demir, Yaşar Çalışkan, null null, Yagmur Goksoy, null null, Fadime Sevgi Sacli, null null, Ummu Mutlu, null null, Aydın Türkmen, null null, Semra Bozfakioglu, null null
Publié dans: Turkish Journal of Nephrology, Numéro 33, 2024, Page(s) 223-228, ISSN 2667-4440
Éditeur: Aves
DOI: 10.5152/turkjnephrol.2024.22491

Risk Stratification Before Living Donor Kidney Transplantation in Patients With Preformed Donor-specific Antibodies by Different Crossmatch Methods

Auteurs: Malte Ziemann, Monika Lindemann, Michael Hallensleben, Wolfgang Altermann, Karina Althaus, Klemens Budde, Gunilla Einecke, Ute Eisenberger, Andrea Ender, Thorsten Feldkamp, Florian Grahammer, Martina Guthoff, Christopher Holzmann-Littig, Christian Hugo, Teresa Kauke, Stephan Kemmner, Martina Koch, Nils Lachmann, Matthias Marget, Christian Morath, Martin Nitschke, Lutz Renders, Sabine Scherer, Juli
Publié dans: Transplantation Direct, Numéro 10, 2025, Page(s) e1680, ISSN 2373-8731
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/txd.0000000000001680

Does <i>de novo</i> malignancy heighten the risk of rejection in kidney transplant recipients?

Auteurs: Erol Demir, Mevlut Tamer Dincer, Cebrail Karaca, Cansu Erel, Latif Karahan, Aslihan Pekmezci, Sinan Trabulus, Nurhan Seyahi, Aydin Turkmen
Publié dans: Clinical Kidney Journal, Numéro 17, 2024, ISSN 2048-8505
Éditeur: Oxford University Press
DOI: 10.1093/ckj/sfae349

A multinational cohort study uncovered sex differences in excess mortality after kidney transplant

Auteurs: Amanda J Vinson , Xun Zhang , Mourad Dahhou , Caner Süsal , Bernd Döhler , Anette Melk , Ruth Sapir-Pichhadze , Heloise Cardinal , Germaine Wong , Anna Francis , Helen Pilmore , Bethany J Foster
Publié dans: Kidney International, Numéro Volume 103, Numéro 6, 2023, Page(s) 1131 - 1143, ISSN 0085-2538
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2023.01.022

New Tools for Data Harmonization and Their Potential Applications in Organ Transplantation

Auteurs: Seyed Amir Tabatabaei Hosseini, Reza Kazemzadeh, Bethany Joy Foster, Emre Arpali, Caner Süsal
Publié dans: Transplantation, Numéro 108, 2025, Page(s) 2306-2317, ISSN 0041-1337
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000005048

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Publications

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