Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies

Deliverables

Bioaccumulation and persistency evaluation of selected NMs

Report describing the bioaccumulation at the entry-point of the trophic chain, according to the data obtained for algae and daphnia, and the possibilities of biomagnification according to the data obtained for fish. Since persistency of the NMs plays a key role in bioaccumulation by determining the availability of NMs for organisms, the report will incorporate the results of the persistency studies.

Overview of relevant AOPs to inform NAM choice of KEs

Report summarizing relevant AOPs and selection of candidate Key Events and Adverse Outcomes suitable forNAM in WP3

Open access repository of mRNA single cell response

Open access repository of mRNA single cell response profiles detected in lung tissue flowing pulmonary exposure. Report on the comparison of lung single cell response profiles of (intubated ventilated) inhalation and instillation exposed rodents.

HARMLESS database with extensions to handle advanced materials

The report will include description of HARMLESS-eNanoMapper database setup, content and ontology annotations, and the implemented approach of advanced materials representation.

Publications

Breathing-induced stretch enhances the efficacy of an inhaled and orally delivered anti-fibrosis drug in vitro

Author(s): Doryab, A., Heydarian, M., Yildirim, A.Ö., Hilgendorff, A., Behr, J., Schmid, O.,
Published in: Journal of Drug Delivery Science and Technology, Issue 85, 2023, Page(s) still ePub, ISSN 1773-2247
Publisher: Editions de Sante
DOI: 10.1016/j.jddst.2023.104316

evaluating use and performance

Author(s): Krans, N A; Ammar, A; Nymark, P; Willighagen, E L; Bakker, M I; Quik, J T K
Published in: NanoImpact, Issue 24520748, 2022, ISSN 2452-0748
Publisher: Elservier BV
DOI: 10.1016/j.impact.2022.100402

Towards Computer-Aided Graphene Covered TiO2-Cu/(CuxOy) Composite Design for the Purpose of Photoinduced Hydrogen Evolution

Author(s): Łukasz Lewandowski; Agnieszka Gajewicz-Skretna; Tomasz Klimczuk; Grzegorz Trykowski; Kostiantyn Nikiforow; Wojciech Lisowski; Anna Gołąbiewska; Adriana Zaleska-Medynska
Published in: Catalysts Issue 6, Issue 2, 2021, ISSN 2073-4344
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal11060698

Single-walled vs. Multi-walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses of Mouse Lungs

Author(s): Silvia A. Solorio-Rodriguez, Andrew Williams, Sarah Søs Poulsen, Kristina B. Knudsen, Keld Alstrup Jensen, Per A. Clausen, Pernille Høgh Danielsen, Håkan Wallin, Ulla Vogel, Sabina Halappanavar
Published in: "NanoMaterials - Special Issue ""Safety and Toxicity of Carbon Nanotubes""", Issue 13, 2023, Page(s) 1059, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13061059

Meta‐Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure–Activity Relationship of Carbon Materials with Different Morphologies

Author(s): Verónica I. Dumit; Yuk‐Chien Liu; Aileen Bahl; Pekka Kohonen; Roland C. Grafström; Penny Nymark; Christine Müller‐Graf; Andrea Haase; Mario Pink
Published in: Advanced Science, Issue 2, 2023, ISSN 1613-6829
Publisher: Wiley Online Library
DOI: 10.1002/advs.202306268

Referee report. For: ELIXIR and Toxicology: a community in development [version 1; peer review: 1 approved, 1 approved with reservations]

Author(s): Eide, Marta
Published in: ELIXIR, Issue 3, 2023, ISSN 2229-712X
Publisher: F1000 Research
DOI: 10.5256/f1000research.78265.r124031

Editorial: Exploring impacts of combined exposures to particles and chemicals on immune reactions across living organisms

Author(s): Diana Boraschi, Albert Duschl, Iseult Lynch and Tobias Stoeger
Published in: Frontiers in Toxicology, Issue 5, 2023, Page(s) still ePub, ISSN 2673-3080
Publisher: Frontiers in Toxicology
DOI: 10.3389/ftox.2023.1148374

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials

Author(s): Bannuscher, A., Schmid, O., et al. Doryab, A., et al. Clift, M.J.D., Rothen-Rutishauser, B.
Published in: NanoImpact, Issue 28, 2022, Page(s) 100439, ISSN 2452-0748
Publisher: ScienceDirect
DOI: 10.1016/j.impact.2022.100439

ELIXIR and Toxicology: a community in development

Author(s): Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Published in: ELIXIR and Toxicology: a community in development, Issue 20461402, 2021, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.1

Behaviour of advanced materials in environmental aquatic media – dissolution kinetics and dispersion stability of perovskite automotive catalysts

Author(s): Veronica Di Battista; Kai Werle; Lars Michael Skjolding; Wendel Wohlleben; Anders Baun
Published in: Environmental science: Nano, on the special issue on Advanced Materials, Issue 2, 2023, ISSN 2754-7000
Publisher: RSC - The Royal Society of Chemistry
DOI: 10.1039/d3en00685a

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Author(s): Irini Furxhi, Anna Costa, Socorro Vázquez-Campos, Carlos Fito-López, Danail Hristozov, Juan Antonio Tamayo Ramos, Susanne Resch, Margherita Cioffi, Steffi Friedrichs, Cris Rocca, Eugenia Valsami-Jones, Iseult Lynch, Sánchez Jiménez Aracelil, Lucian Farcal
Published in: RSC Sustainability, 2023, ISSN 2753-8125
Publisher: The Royal Society of Chemistry
DOI: 10.1039/d2su00101b

Transferability and reproducibility of exposed air-liquid interface co-culture lung models

Author(s): Hedwig M, Braakhuis; Eric R, Gremmer; Anne, Bannuscher; Barbara, Drasler; Sandeep, Keshavan; Barbara, Rothen-Rutishauser; Barbara, Birk; Andreas, Verlohner; Robert, Landsiedel; Kirsty, Meldrum; Shareen H, Doak; Martin J D, Clift; Johanna Samulin, Erdem; Oda A H, Foss; Shanbeh, Zienolddiny-Narui; Tommaso, Serchi; Elisa, Moschini; Pamina, Weber; Sabina, Burla; Pramod, Kumar; Otmar, Schmid; Edwin, Zw
Published in: NanoImpact, Issue 4, 2023, ISSN 2452-0748
Publisher: ScienceDirect
DOI: 10.1016/j.impact.2023.100466

Effect of Exposure Concentration and Growth Conditions on the Association of Cerium Oxide Nanoparticles with Green Algae

Author(s): Aiga Mackevica; Lyndsey Hendriks; Olga Meili-Borovinskaya; Anders Baun; Lars Michael Skjolding
Published in: Nanomaterials , vol. 13 , no. 17, Issue 2, 2023, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13172468

Release of particulate matter from nano-enabled building materials (NEBMs) across their lifecycle: Potential occupational health and safety implications

Author(s): Dilpreet Singh, Antonella Marrocco, Wendel Wohlleben, Hae-Ryung Park, Avantika R. Diwadkar, Blanca E. Himes, Quan Lu, David C. Christiani, Philip Demokritou
Published in: Journal of Hazarous Materials, Issue 03043894, 2022, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2021.126771

Prospective environmental risk screening of seven advanced materials based on production volumes and aquatic ecotoxicity

Author(s): Rickard Arvidsson; Gregory Peters; Steffen Foss Hansen; Anders Baun
Published in: NanoImpact, Issue 24520748, 2022, ISSN 2452-0748
Publisher: Elsevier BV
DOI: 10.1016/j.impact.2022.100393

A novel quantitative read-across tool designed purposefully to fill the existing gaps in nanosafety data

Author(s): Mainak Chatterjee; Arkaprava Banerjee; Priyanka De; Agnieszka Gajewicz-Skretna; Kunal Roy
Published in: Environmental Science: Nano, Issue 1, 2021, ISSN 2051-8153
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en00725d

highlights from the Basic and Translational Science Assembly

Author(s): Sara Cuevas Ocaña; Natalia El-Merhie; Merian E. Kuipers; Mareike Lehmann; Sara Rolandsson Enes; Carola Voss; Lareb S.N. Dean; Matthew Loxham; Agnes W. Boots; Suzanne M. Cloonan; Catherine M. Greene; Irene H. Heijink; Audrey Joannes; Arnaud A. Mailleux; Nahal Mansouri; Niki L. Reynaert; Anne M. van der Does; Darcy E. Wagner; Niki Ubags
Published in: Erj Open Research, Issue 2, 2023, ISSN 2312-0541
Publisher: European Respiratory Society
DOI: 10.1183/23120541.00561-2022

Lung Organoids for Hazard Assessment of Nanomaterials

Author(s): Miriam T. Kastlmeier; Eva M. Guenther; Tobias Stoeger; Carola Voss
Published in: Int. J. Mol. Sci. 23:15666 (2022), Issue 4, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415666

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Author(s): Andreas Falk; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Mar
Published in: INISS-nano, 2022
Publisher: Concept Paper
DOI: 10.5281/zenodo.6818049

International Network Initiative on Safe and Sustainable Nanotechnologies (INISS-nano)

Author(s): Falk, Andreas
Published in: INISS-nano, 2021
Publisher: Concept Paper
DOI: 10.5281/zenodo.5004929

Engineered nanomaterial-relevant AOPs; network creation and identification of key nodes for adverse outcomes

Author(s): Pousen, Sarah Søs; Baun, Anders; Stöger, Tobias; Navas, José María; Connolly, Mona; Vogel, Ulla B.
Published in: Issue 1, 2022
Publisher: “Nano-week” & NanoCommons Final Conference
DOI: 10.5281/zenodo.6806067

AOP training session

Author(s): Vogel, Ulla; Poulsen, Sarah Søs
Published in: 2022
Publisher: NanoWeek 2022 and NanoCommons Final Conference
DOI: 10.5281/zenodo.6806125

Conceptual Design of the HARMLESS Decision Support System

Author(s): van Someren, Eugene; Shandilya, Neeraj; Franken, Remy; Krone, Tanja; van Stokkum, Robin; Suarez-Merino, Blanca; Adam, Véronique; Salieri, Beatrice; Wohlleben, Wendel; Kalkman, Gino; van Barneveld, Mark; Tolios, Ioannis; Rubingh, Carina; Krishnan, Shaji; Fransman, Wouter; Dekkers, Susan
Published in: Issue 2, 2022
Publisher: “Nano-week” & NanoCommons Final Conference
DOI: 10.5281/zenodo.6806190

Reply to: Prospects and challenges for FAIR toxicogenomics data

Author(s): Roland Grafström; Andrea Haase; Pekka Kohonen; Nina Jeliazkova; Penny Nymark
Published in: Nature Nanotechnology, Issue 17483387, 2022, Page(s) 19-20, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-021-01050-8

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