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Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies

Project description

Evaluating the performance and safety of future nanomaterials

As nanotechnology advances, a plethora of nanomaterials have been fabricated, which have found application in various sectors. Next-generation nanomaterials, however, challenge the existing risk assessment and management paradigm. Nanoparticles are considered mixtures for toxicological research, and therefore, as multi-constituent materials, they display much more complex behaviour. The morphologies and stoichiometry of next-generation advanced nanomaterials cannot be considered risk-free, as designs including high aspect ratio shapes and heavy metal content are abundant. The EU-funded HARMLESS project will offer novel tools, guidance as well as decision support for balancing functionality versus risk to ensure next-generation nanomaterials are harmless.

Objective

Next generation nanomaterials are a challenge for the established risk assessment and management paradigm. The regulatory frameworks have just been modified to address risk assessment of primary nanomaterials with simple coatings and are currently in the first phase of implementing methods and tools adequate for simple nanomaterials. Next generation nanomaterials and products thereof, are multiconstuent materials which exhibit much more complex behaviour, potentially including mixture toxicology. The morphologies and stoichiometry of next generation advanced nanomaterials are not harmless, as designs including high aspect ratio shapes and heavy metal content are abundant. By elucidating the role of nanostructures, their transformation and initiation of adverse outcome pathways, HARMLESS will provide novel tools, guidance and decision support for balancing functionality versus risk to ensure that the next generation nanomaterials will be harmless.

Call for proposal

H2020-NMBP-TO-IND-2018-2020

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Sub call

H2020-NMBP-TO-IND-2020-twostage

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Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Net EU contribution
€ 914 375,00
Address
Ingolstadter landstrasse 1
85764 Neuherberg
Germany

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Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
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Other funding
€ 0,00

Participants (19)