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GUT VIrus BRain Axis Technology In OrgaNoid Science

Objective

The battle against infectious diseases is hampered by lack of therapeutic innovations due to poor understanding of disease outcome in humans. Organoid technology is a major breakthrough for medical research that has traditionally relied heavily on animal models. In our current OrganoVIR consortium, we are at the forefront in establishing human organoids as superior models for viral pathogenesis and antiviral research. The next critical step is to integrate organoid models to create a complex multi-organ ex vivo model that better mimics the human physiology. This raises several challenges such as incorporation of various cell types, medium incompatibility, validation, high throughput, and robust ways to connect mature organoid models. At the same time, the model has to be accessible, user friendly, and affordable to all end users. Therefore, this proposed GUTVIBRATIONS consortium will leverage its expertise in microfabrication, organoid technology, virology, immunology, bioengineering, and materials science to deliver an enabling organ-on-chip system.

As a demonstrator, a modular human gut-brain axis multi-organ model will be achieved for studying viral disease and treatment. This model will be built by combining an open source 3D printed scaffold technology with human gut and brain organoid models. The deliverables will include a complex gut epithelial layer, immune cell layer, blood-brain layer and brain organoid; all individually developed and subsequently connected by vertical stacking. Our unique modular approach where individual components are separately developed and validated minimizes compatibility issues. The individual models and the multi-organ model will be used for studying three different clinically relevant viral infections with high global burden and will be validated against existing clinical data to bring the system to TRL5. Routes towards commercialization will also be assessed by performing a market analysis and developing a business plan.

Call for proposal

H2020-NMBP-TR-IND-2020-twostage
See other projects for this call

Funding Scheme

RIA-LS - Research and Innovation action Lump Sum

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 020 500

Participants (6)

DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 971 250
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 514 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
UNIQURE BIOPHARMA BV
Netherlands
EU contribution
€ 620 625
Address
Paasheuvelweg 25
1105BP Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOLAMINA AB
Sweden
EU contribution
€ 542 500
Address
Lofstroms Alle 5A
172 66 Sundbyberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STEMCELL TECHNOLOGIES UK LTD
United Kingdom
EU contribution
€ 967 500
Address
Building 7100 Cambridgde Research Park Beach Drive Waterbeach
CB25 9TL Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 425 000
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments