EU Training Network in understanding the molecular regulation and the role of endo-lysosomal processes in cardio-metabolic diseases

Project Information

EndoConnect

Grant agreement ID: 953489

DOI

10.3030/953489

Project closed

EC signature date 3 September 2020

Start date 1 January 2021

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 050 849,24

EU contribution

€ 4 050 849,24

Coordinated by

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (8)

Press release start/end EndoConnect
Recruitment of the ESRs completed
Oral/Poster presentations, Reviews/Scientific publications
EndoConnect animation movies
EndoConnect website, Facebook group page, Twitter acount

EndoConnect website Facebook group page Twitter acount

Completion of doctoral programme - awarding of doctoral degrees

Completion of doctoral programme – awarding of doctoral degrees

The first EndoConnect Symposium
Training certificate for all ESRs

Documents, reports (1)

Supervisory Board of the network

Publications

Peer reviewed articles (18)

ERICH4 is not involved in the assembly and secretion of intestinal lipoproteins

Author(s): Ankia Visser, Willemien van Zwol, Niels Kloosterhuis, Nicolette Huijkman, Marieke Smit, Mirjam Koster, Vincent Bloks, M. Mahmood Hussain, Bart van de Sluis, Jan Albert Kuivenhoven
Published in: Atherosclerosis, Issue 399, 2024, Page(s) 118635, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.118635

Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling

Author(s): Ellen Thiemann, Gerburg K Schwaerzer, Ioannis Evangelakos, Marceline M Fuh, Michelle Y Jaeckstein, Janina Behrens, Stefan K Nilsson, Manju Kumari, Ludger Scheja, Alexander Pfeifer, Joerg Heeren, Markus Heine
Published in: Frontiers in Physiology, Issue 2022; 13: 859671, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.859671

The low-density lipoprotein receptor: emerging post-transcriptional regulatory mechanisms

Author(s): Klevis Ndoj, Amber Meurs, Dimitra Papaioannou, Katrine Bjune, Noam Zelcer
Published in: Atherosclerosis, 2024, Page(s) 119082, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.119082

Cholesterol transport in the late endocytic pathway: Roles of ORP family proteins

Author(s): Vesa Olkkonen, Elina Ikonen
Published in: J Steroid Biochem Mol Biol, Issue 2022 Feb;216:106040, 2022, ISSN 1879-1220
Publisher: Elsevier
DOI: 10.1016/j.jsbmb.2021.106040

Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation

Author(s): Camilla Ruffilli, Sascha Roth, Monica Rodrigo, Helen Boyd, Noam Zelcer, Kevin Moreau
Published in: ACS Pharmacology & Translational Science, Issue 2022, 5, 10, 2022, Page(s) 849-858, ISSN 2575-9108
Publisher: ACS Pharmacology & Translational Science
DOI: 10.1021/acsptsci.2c00142

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Author(s): Willemien van Zwol, Antoine Rimbert, Justina C Wolters, Marieke Smit, Vincent W Bloks, Niels J Kloosterhuis, Nicolette C A Huijkman, Mirjam H Koster, Umesh Tharehalli, Simon M de Neck, Colin Bournez, Marceline M Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N Ginsberg, Gerard J P van Westen, M Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van
Published in: Hepatology, Issue 2022 Sep 2, 2022, Page(s) online ahead of print, ISSN 1527-3350
Publisher: Wiley Periodicals LLC
DOI: 10.1002/hep.32709

Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway

Author(s): Rebeka Butkovič, Alexander P. Walker, Michael D. Healy, Kerrie E. McNally, Meihan Liu, Tineke Veenendaal, Kohji Kato, Nalan Liv, Judith Klumperman, Brett M. Collins, Peter J. Cullen
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-50971-0

Structure of the Commander Endosomal Trafficking Complex Linked to X-Linked Intellectual Disability/Ritscher-Schinzel Syndrome

Author(s): Michael D. Healy, Kerrie E. McNally, Rebeka Butkovic, Molly Chilton, Kohji Kato, Joanna Sacharz, Calum McConville, Edmund Moody, Shrestha Shaw, Vincente Planelles-Herrero, Sathish Yadav, Jennifer Ross, Ufuk Borucu, Catherine Palmer, Kai-En Chen, Tristan Croll, Ryan Hall, Nikeisha Caruana, Rajesh Ghai, Thi Nguyen, Kate Heesom, Shinji Saitoh, Imre Berger, Christiane Schaffitzel, Tom Williams, Davi
Published in: Cell, 2023, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.2139/ssrn.4330804

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Author(s): Michael D. Healy, Kerrie E. McNally, Rebeka Butkovič, Molly Chilton, Kohji Kato, Joanna Sacharz, Calum McConville, Edmund R.R. Moody, Shrestha Shaw, Vicente J. Planelles-Herrero, Sathish K.N. Yadav, Jennifer Ross, Ufuk Borucu, Catherine S. Palmer, Kai-En Chen, Tristan I. Croll, Ryan J. Hall, Nikeisha J. Caruana, Rajesh Ghai, Thi H.D. Nguyen, Kate J. Heesom, Shinji Saitoh, Imre Berger, Christiane
Published in: Cell, Issue 186, 2023, Page(s) 2219-2237.e29, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.04.003

Managing of Dyslipidaemia Characterized by Accumulation of Triglyceride-Rich Lipoproteins

Author(s): Jolien Visser, Willemien van Zwol, Jan Albert Kuivenhoven
Published in: Current Atherosclerosis Reports, Issue 2022 Jan;24(1):1-12, 2022, Page(s) 1-12, ISSN 1534-6242
Publisher: Springer Nature
DOI: 10.1007/s11883-022-00979-y

Inhibition of polyploidization in Pten-deficient livers reduces steatosis

Author(s): Eva Moreno, Augustine B Matondo, Laura Bongiovanni, Chris H A van de Lest, Martijn R Molenaar, Mathilda J M Toussaint, Saskia C van Essen, Martin Houweling, J Bernd Helms, Bart Westendorp, Alain de Bruin
Published in: Liver International, Issue 2022 Nov;42(11), 2022, Page(s) 2442-2452, ISSN 1478-3231
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/liv.15384

Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins

Author(s): Dyonne Y Vos, Melinde Wijers, Marieke Smit, Nicolette Huijkman, Niels J Kloosterhuis, Justina C Wolters, Joël J Tissink, Amanda C M Pronk, Sander Kooijman, Patrick C N Rensen, Jan Albert Kuivenhoven, Bart van de Sluis
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 2023;43, 2023, Page(s) e29–e45, ISSN 1524-4636
Publisher: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.122.318169

Endosomal trafficking in metabolic homeostasis and diseases

Author(s): Jerome Gilleron, Anja Zeigerer
Published in: Nature Reviews Endocrinology, Issue 19, 2023, Page(s) 28-45, ISSN 1759-5037
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-022-00737-9

Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)

Author(s): Dyonne Y Vos, Bart van de Sluis
Published in: Molecular Metabolism, Issue 2021 Aug; 50: 101146, 2021, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101146

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease

Author(s): Tamara Marín, Andrés E. Dulcey, Fabián Campos, Catalina de la Fuente, Mariana Acuña, Juan Castro, Claudio Pinto, María José Yañez, Cristian Cortez, David W. McGrath, Pablo J. Sáez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugán, Alejandra R. Alvarez, Silvana Zanlungo
Published in: Frontiers in Cell and Developmental Biology, Issue 10, 2022, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2022.844297

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Author(s): Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G Okun, Michael Roden, Matthias Blüher, Timo D Müller, Natalie Krahmer, Christian Behrends, Oliver Plettenburg, Marta Miaczynska, Stephan Herzig, Anja
Published in: Cell Metabolism, Issue 2022 Nov 1;34(11):1824-1842.e9, 2022, Page(s) 1824-1842, ISSN 1626-3200
Publisher: Elsevier
DOI: 10.1016/j.cmet.2022.09.022

A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion

Author(s): Amber Meurs, Klevis Ndoj, Marlene van den Berg, Goran Marinković, Matteo Tantucci, Tineke Veenendaal, Jan Albert Kuivenhoven, Judith Klumperman, Noam Zelcer
Published in: Cardiovascular Research, Issue 120, 2024, Page(s) 1253-1264, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvae121

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Author(s): Andries Heida, Theo van Dijk, Marieke Smit, Martijn Koehorst, Mirjam Koster, Niels Kloosterhuis, Rick Havinga, Vincent W. Bloks, Justina C. Wolters, Alain de Bruin, Jan Albert Kuivenhoven, Jan Freark de Boer, Folkert Kuipers, Bart van de Sluis
Published in: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Issue 1869, 2024, Page(s) 159445, ISSN 1388-1981
Publisher: Elsevier BV
DOI: 10.1016/j.bbalip.2023.159445