EU Training Network in understanding the molecular regulation and the role of endo-lysosomal processes in cardio-metabolic diseases

Project Information

EndoConnect

Grant agreement ID: 953489

DOI 10.3030/953489

EC signature date 3 September 2020

Start date 1 January 2021

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 4 050 849,24

EU contribution € 4 050 849,24

Coordinated by

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

Deliverables

Other (4)

Recruitment of the ESRs completed
EndoConnect animation movies
EndoConnect website, Facebook group page, Twitter acount

EndoConnect website Facebook group page Twitter acount

The first EndoConnect Symposium

Documents, reports (1)

Supervisory Board of the network

Publications

Peer reviewed articles (9)

Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling

Author(s): Ellen Thiemann, Gerburg K Schwaerzer, Ioannis Evangelakos, Marceline M Fuh, Michelle Y Jaeckstein, Janina Behrens, Stefan K Nilsson, Manju Kumari, Ludger Scheja, Alexander Pfeifer, Joerg Heeren, Markus Heine
Published in: Frontiers in Physiology, Issue 2022; 13: 859671, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.859671

Cholesterol transport in the late endocytic pathway: Roles of ORP family proteins

Author(s): Vesa Olkkonen, Elina Ikonen
Published in: J Steroid Biochem Mol Biol, Issue 2022 Feb;216:106040, 2022, ISSN 1879-1220
Publisher: Elsevier
DOI: 10.1016/j.jsbmb.2021.106040

Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation

Author(s): Camilla Ruffilli, Sascha Roth, Monica Rodrigo, Helen Boyd, Noam Zelcer, Kevin Moreau
Published in: ACS Pharmacology & Translational Science, Issue 2022, 5, 10, 2022, Page(s) 849-858, ISSN 2575-9108
Publisher: ACS Pharmacology & Translational Science
DOI: 10.1021/acsptsci.2c00142

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Author(s): Willemien van Zwol, Antoine Rimbert, Justina C Wolters, Marieke Smit, Vincent W Bloks, Niels J Kloosterhuis, Nicolette C A Huijkman, Mirjam H Koster, Umesh Tharehalli, Simon M de Neck, Colin Bournez, Marceline M Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N Ginsberg, Gerard J P van Westen, M Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van
Published in: Hepatology, Issue 2022 Sep 2, 2022, Page(s) online ahead of print, ISSN 1527-3350
Publisher: Wiley Periodicals LLC
DOI: 10.1002/hep.32709

Managing of Dyslipidaemia Characterized by Accumulation of Triglyceride-Rich Lipoproteins

Author(s): Jolien Visser, Willemien van Zwol, Jan Albert Kuivenhoven
Published in: Current Atherosclerosis Reports, Issue 2022 Jan;24(1):1-12, 2022, Page(s) 1-12, ISSN 1534-6242
Publisher: Springer Nature
DOI: 10.1007/s11883-022-00979-y

Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins

Author(s): Dyonne Y Vos, Melinde Wijers, Marieke Smit, Nicolette Huijkman, Niels J Kloosterhuis, Justina C Wolters, Joël J Tissink, Amanda C M Pronk, Sander Kooijman, Patrick C N Rensen, Jan Albert Kuivenhoven, Bart van de Sluis
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 2023;43, 2023, Page(s) e29–e45, ISSN 1524-4636
Publisher: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.122.318169

Endosomal trafficking in metabolic homeostasis and diseases

Author(s): Jerome Gilleron, Anja Zeigerer
Published in: Nature Reviews Endocrinology, Issue 19, 2023, Page(s) 28-45, ISSN 1759-5037
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-022-00737-9

Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)

Author(s): Dyonne Y Vos, Bart van de Sluis
Published in: Molecular Metabolism, Issue 2021 Aug; 50: 101146, 2021, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101146

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Author(s): Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G Okun, Michael Roden, Matthias Blüher, Timo D Müller, Natalie Krahmer, Christian Behrends, Oliver Plettenburg, Marta Miaczynska, Stephan Herzig, Anja
Published in: Cell Metabolism, Issue 2022 Nov 1;34(11):1824-1842.e9, 2022, Page(s) 1824-1842, ISSN 1626-3200
Publisher: Elsevier
DOI: 10.1016/j.cmet.2022.09.022