EU Training Network in understanding the molecular regulation and the role of endo-lysosomal processes in cardio-metabolic diseases

Informazioni relative al progetto

EndoConnect

ID dell’accordo di sovvenzione: 953489

DOI

10.3030/953489

Progetto chiuso

Data della firma CE 3 Settembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Marzo 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 050 849,24

Contributo UE

€ 4 050 849,24

Coordinato da

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (8)

Press release start/end EndoConnect
Recruitment of the ESRs completed
Oral/Poster presentations, Reviews/Scientific publications
EndoConnect animation movies
EndoConnect website, Facebook group page, Twitter acount

EndoConnect website Facebook group page Twitter acount

Completion of doctoral programme - awarding of doctoral degrees

Completion of doctoral programme – awarding of doctoral degrees

The first EndoConnect Symposium
Training certificate for all ESRs

Documents, reports (1)

Supervisory Board of the network

Pubblicazioni

Peer reviewed articles (18)

ERICH4 is not involved in the assembly and secretion of intestinal lipoproteins

Autori: Ankia Visser, Willemien van Zwol, Niels Kloosterhuis, Nicolette Huijkman, Marieke Smit, Mirjam Koster, Vincent Bloks, M. Mahmood Hussain, Bart van de Sluis, Jan Albert Kuivenhoven
Pubblicato in: Atherosclerosis, Numero 399, 2024, Pagina/e 118635, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.118635

Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling

Autori: Ellen Thiemann, Gerburg K Schwaerzer, Ioannis Evangelakos, Marceline M Fuh, Michelle Y Jaeckstein, Janina Behrens, Stefan K Nilsson, Manju Kumari, Ludger Scheja, Alexander Pfeifer, Joerg Heeren, Markus Heine
Pubblicato in: Frontiers in Physiology, Numero 2022; 13: 859671, 2022, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.859671

The low-density lipoprotein receptor: emerging post-transcriptional regulatory mechanisms

Autori: Klevis Ndoj, Amber Meurs, Dimitra Papaioannou, Katrine Bjune, Noam Zelcer
Pubblicato in: Atherosclerosis, 2024, Pagina/e 119082, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.119082

Cholesterol transport in the late endocytic pathway: Roles of ORP family proteins

Autori: Vesa Olkkonen, Elina Ikonen
Pubblicato in: J Steroid Biochem Mol Biol, Numero 2022 Feb;216:106040, 2022, ISSN 1879-1220
Editore: Elsevier
DOI: 10.1016/j.jsbmb.2021.106040

Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation

Autori: Camilla Ruffilli, Sascha Roth, Monica Rodrigo, Helen Boyd, Noam Zelcer, Kevin Moreau
Pubblicato in: ACS Pharmacology & Translational Science, Numero 2022, 5, 10, 2022, Pagina/e 849-858, ISSN 2575-9108
Editore: ACS Pharmacology & Translational Science
DOI: 10.1021/acsptsci.2c00142

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Autori: Willemien van Zwol, Antoine Rimbert, Justina C Wolters, Marieke Smit, Vincent W Bloks, Niels J Kloosterhuis, Nicolette C A Huijkman, Mirjam H Koster, Umesh Tharehalli, Simon M de Neck, Colin Bournez, Marceline M Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N Ginsberg, Gerard J P van Westen, M Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van
Pubblicato in: Hepatology, Numero 2022 Sep 2, 2022, Pagina/e online ahead of print, ISSN 1527-3350
Editore: Wiley Periodicals LLC
DOI: 10.1002/hep.32709

Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway

Autori: Rebeka Butkovič, Alexander P. Walker, Michael D. Healy, Kerrie E. McNally, Meihan Liu, Tineke Veenendaal, Kohji Kato, Nalan Liv, Judith Klumperman, Brett M. Collins, Peter J. Cullen
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-50971-0

Structure of the Commander Endosomal Trafficking Complex Linked to X-Linked Intellectual Disability/Ritscher-Schinzel Syndrome

Autori: Michael D. Healy, Kerrie E. McNally, Rebeka Butkovic, Molly Chilton, Kohji Kato, Joanna Sacharz, Calum McConville, Edmund Moody, Shrestha Shaw, Vincente Planelles-Herrero, Sathish Yadav, Jennifer Ross, Ufuk Borucu, Catherine Palmer, Kai-En Chen, Tristan Croll, Ryan Hall, Nikeisha Caruana, Rajesh Ghai, Thi Nguyen, Kate Heesom, Shinji Saitoh, Imre Berger, Christiane Schaffitzel, Tom Williams, Davi
Pubblicato in: Cell, 2023, ISSN 0092-8674
Editore: Cell Press
DOI: 10.2139/ssrn.4330804

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Autori: Michael D. Healy, Kerrie E. McNally, Rebeka Butkovič, Molly Chilton, Kohji Kato, Joanna Sacharz, Calum McConville, Edmund R.R. Moody, Shrestha Shaw, Vicente J. Planelles-Herrero, Sathish K.N. Yadav, Jennifer Ross, Ufuk Borucu, Catherine S. Palmer, Kai-En Chen, Tristan I. Croll, Ryan J. Hall, Nikeisha J. Caruana, Rajesh Ghai, Thi H.D. Nguyen, Kate J. Heesom, Shinji Saitoh, Imre Berger, Christiane
Pubblicato in: Cell, Numero 186, 2023, Pagina/e 2219-2237.e29, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2023.04.003

Managing of Dyslipidaemia Characterized by Accumulation of Triglyceride-Rich Lipoproteins

Autori: Jolien Visser, Willemien van Zwol, Jan Albert Kuivenhoven
Pubblicato in: Current Atherosclerosis Reports, Numero 2022 Jan;24(1):1-12, 2022, Pagina/e 1-12, ISSN 1534-6242
Editore: Springer Nature
DOI: 10.1007/s11883-022-00979-y

Inhibition of polyploidization in Pten-deficient livers reduces steatosis

Autori: Eva Moreno, Augustine B Matondo, Laura Bongiovanni, Chris H A van de Lest, Martijn R Molenaar, Mathilda J M Toussaint, Saskia C van Essen, Martin Houweling, J Bernd Helms, Bart Westendorp, Alain de Bruin
Pubblicato in: Liver International, Numero 2022 Nov;42(11), 2022, Pagina/e 2442-2452, ISSN 1478-3231
Editore: John Wiley & Sons Ltd
DOI: 10.1111/liv.15384

Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins

Autori: Dyonne Y Vos, Melinde Wijers, Marieke Smit, Nicolette Huijkman, Niels J Kloosterhuis, Justina C Wolters, Joël J Tissink, Amanda C M Pronk, Sander Kooijman, Patrick C N Rensen, Jan Albert Kuivenhoven, Bart van de Sluis
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 2023;43, 2023, Pagina/e e29–e45, ISSN 1524-4636
Editore: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.122.318169

Endosomal trafficking in metabolic homeostasis and diseases

Autori: Jerome Gilleron, Anja Zeigerer
Pubblicato in: Nature Reviews Endocrinology, Numero 19, 2023, Pagina/e 28-45, ISSN 1759-5037
Editore: Nature Publishing Group
DOI: 10.1038/s41574-022-00737-9

Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)

Autori: Dyonne Y Vos, Bart van de Sluis
Pubblicato in: Molecular Metabolism, Numero 2021 Aug; 50: 101146, 2021, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101146

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease

Autori: Tamara Marín, Andrés E. Dulcey, Fabián Campos, Catalina de la Fuente, Mariana Acuña, Juan Castro, Claudio Pinto, María José Yañez, Cristian Cortez, David W. McGrath, Pablo J. Sáez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugán, Alejandra R. Alvarez, Silvana Zanlungo
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 10, 2022, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2022.844297

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Autori: Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G Okun, Michael Roden, Matthias Blüher, Timo D Müller, Natalie Krahmer, Christian Behrends, Oliver Plettenburg, Marta Miaczynska, Stephan Herzig, Anja
Pubblicato in: Cell Metabolism, Numero 2022 Nov 1;34(11):1824-1842.e9, 2022, Pagina/e 1824-1842, ISSN 1626-3200
Editore: Elsevier
DOI: 10.1016/j.cmet.2022.09.022

A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion

Autori: Amber Meurs, Klevis Ndoj, Marlene van den Berg, Goran Marinković, Matteo Tantucci, Tineke Veenendaal, Jan Albert Kuivenhoven, Judith Klumperman, Noam Zelcer
Pubblicato in: Cardiovascular Research, Numero 120, 2024, Pagina/e 1253-1264, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvae121

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Autori: Andries Heida, Theo van Dijk, Marieke Smit, Martijn Koehorst, Mirjam Koster, Niels Kloosterhuis, Rick Havinga, Vincent W. Bloks, Justina C. Wolters, Alain de Bruin, Jan Albert Kuivenhoven, Jan Freark de Boer, Folkert Kuipers, Bart van de Sluis
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Numero 1869, 2024, Pagina/e 159445, ISSN 1388-1981
Editore: Elsevier BV
DOI: 10.1016/j.bbalip.2023.159445