NeuroLF: The best small and mobile dedicated brain PET scanner for an accessible early detection of Alzheimer’s disease

Informations projet

NeuroLF

N° de convention de subvention: 953844

DOI

10.3030/953844

Projet clôturé

Date de signature de la CE 8 Juin 2020

Date de début 1 Avril 2020

Date de fin 30 Septembre 2022

Financé au titre de

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Coût total

€ 3 209 524,00

Contribution de l’UE

€ 2 246 666,80

Coordonné par

POSITRIGO AG
Switzerland

Periodic Reporting for period 2 - NeuroLF (NeuroLF: The best small and mobile dedicated brain PET scanner for an accessible early detection of Alzheimer’s disease )

Période du rapport: 2021-04-01 au 2022-09-30

Résumé du contexte et des objectifs généraux du projet

Among older people in Europe, dementia is the leading cause of dependency and disability. Alzheimer's disease (AD) is the most common type of dementia and early diagnosis is key to its treatment. Currently, a positron emission tomography scan, commonly known as a PET scan, is used to reveal the early microscopic changes in the brain caused by Alzheimer’s disease. However, PET scans are big and expensive, making population-wide screening difficult. The Swiss start-up Positrigo is developing the NeuroLF brain PET system, which is only a tenth of the price (reduced device, personnel and radiotracers costs) and a fifth of the size of traditional scanners. The EU-funded NeuroLF project will focus on the commercialisation of this new technology, which will make brain scanning affordable for everyone.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

In the first year of the NeuroLF project, we have started the design and development process from prototype towards the medical device NeuroLF. The process is governed by our newly established ISO 13485 quality management system and includes mechanics, electronics, and software developments.
We have performed the clinical study ExploreBPET to evaluate the existing prototype in the clinic and identifies aspects to be improved for the current development of NeuroLF.
Meanwhile, we have completed the development of NeuroLF and started to submit the technical documentation to TÜV Süd. With feedback and test results we are fixing the remaining bugs and aim to obtain the CE mark in 2023.
We have started to be visible in the public and have showcased the company and our product NeuroLF on several fairs and congresses. First pre-sales contracts are in sight and will be signed shortly.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

Positrigo aims to disrupt Alzheimer’s Disease diagnostic market and brain imaging field by offering the smallest and cheapest PET scanner adapted to human head. At the end of the project, we expect to have a new prototype tested, which is ready to receive the CE mark and FDA 510k clearance. NeuroLF will be a new tool with which hospitals can make five times more functional brain scans on the same space for lower cost than today. This is a stepping stone for the population-wide early detection of neurodegeneration like Alzheimer’s and subsequent effective treatments by one of the drugs that are approaching regulatory approval.

The first device of the brain PET scanner NeuroLF

Renderning of current design concept of the brain PET scanner NeuroLF