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Training experts in antigen processing to deliver new drug prototypes for cancer and autoimmune diseases

Objective

Current trends in immunotherapy are to develop immuno-modulatory small molecules for intracellular targets for single therapy or combination with existing treatments. CAPSTONE scientists have recently identified the key pathway of intracellular antigen processing for modulating the immune response. ERAP enzymes that generate antigenic peptides have thus emerged as promising targets for the cancer immunotherapy and autoimmune diseases treatments. Our innovative research approach based on ERAP, targets the upstream molecular events that cause these diseases. We aim at fully understanding this pathway, deciphering the mechanisms of antigen processing dysfunctions in diseases, and developing innovative therapeutic drugs. This will provide unique opportunities for future treatment of unmet medical needs and innovative immunotherapies. CAPSTONE will thus be an excellent scientific environment to train the next generation of 15 Early Stage Researchers (ESRs) and establish an innovative cross-fertilisation between oncology and auto-immunity. Our fellows will be able to perform outstanding research at the forefront of transdisciplinary science within a high-calibre international network of academics, industries and patient associations. CAPSTONE brings together an intersectorial and multidisciplinary group of researchers in medicinal chemistry, X-Ray crystallography, cellular biology, oncology, autoimmunity, bioanalysis, mass spectrometry imaging, formulation, systems biology, personalised medicine that will expose the ESRs to key R&D stages, from basic research to pre-clinical development. CAPSTONE will prepare the ESRs for exciting career perspectives in academia, the pharmaceutical industry, biotechnology SMEs, and provide them with scientific and transferable skills and high-value professional connections. Industrial secondments and public engagement will add to a broad skill set to ensure employability in the higher ranks of academia and industry.

Field of science

  • /medical and health sciences/basic medicine/medicinal chemistry
  • /medical and health sciences/basic medicine/immunology/immunotherapy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITE DE LILLE
Address
42 Rue Paul Duez
59800 Lille
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 549 604,08

Participants (9)

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Greece
EU contribution
€ 486 035,28
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Activity type
Research Organisations
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 606 345,12
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE PARIS
France
EU contribution
€ 549 604,08
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
EU contribution
€ 522 999,36
Address
Piazza Sant Onofrio 4
00165 Roma
Activity type
Other
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 243 017,64
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 265 619,88
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
IMABIOTECH SAS
France
EU contribution
€ 274 802,04
Address
152 Rue Du Docteur Yersin
59120 Loos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INOCURE SRO
Czechia
EU contribution
€ 234 871,56
Address
Politickych Veznu 935/13
11000 Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVAMECHANICS LIMITED
Cyprus
EU contribution
€ 235 836,72
Address
Prigkipissis Nte Tyras 16 Karantoki Building 5Th Floor Flat/office 13-14
1065 Nicosia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)