Training experts in antigen processing to deliver new drug prototypes for cancer and autoimmune diseases

Project Information

CAPSTONE

Grant agreement ID: 954992

DOI

10.3030/954992

Project closed

EC signature date 3 September 2020

Start date 1 January 2021

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 968 730,62

EU contribution

€ 3 968 730,62

Coordinated by

UNIVERSITE DE LILLE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

ETN CAPSTONE website

Publications

Peer reviewed articles (17)

ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights

Author(s): Vasileios Fougiaxis, Ben He, Tuhina Khan, Rodolphe Vatinel, Nikoletta M. Koutroumpa, Antreas Afantitis, Laetitia Lesire, Pierre Sierocki, Benoit Deprez, Rebecca Deprez-Poulain
Published in: Journal of Medicinal Chemistry, Issue 67, 2024, Page(s) 11597-11621, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00840

Immunogenic Cell Death Inducers in Cancer Immunotherapy to Turn Cold Tumors into Hot Tumors

Author(s): Valeria Lucarini, Ombretta Melaiu, Paula Gragera, Kamila Król, Valentina Scaldaferri, Verena Damiani, Adele De Ninno, Daniela Nardozi, Luca Businaro, Laura Masuelli, Roberto Bei, Loredana Cifaldi, Doriana Fruci
Published in: International Journal of Molecular Sciences, Issue 26, 2025, Page(s) 1613, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26041613

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties

Author(s): Galateia Georgaki, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1415964

Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma

Author(s): Patrizia Tempora, Silvia D’Amico, Paula Gragera, Verena Damiani, Kamila Krol, Valentina Scaldaferri, Kirti Pandey, Shanzou Chung, Valeria Lucarini, Ezio Giorda, Marco Scarsella, Gabriele Volpe, Marco Pezzullo, Cristiano De Stefanis, Valentina D’Oria, Lorenzo De Angelis, Roberto Giovannoni, Maria Antonietta De Ioris, Ombretta Melaiu, Anthony W. Purcell, Franco Locatelli, Doriana Fruci
Published in: Journal of Experimental & Clinical Cancer Research, Issue 43, 2024, ISSN 1756-9966
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s13046-024-03180-y

First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease

Author(s): Vasileios Fougiaxis, Valentina Barcherini, Milena M. Petrovic, Pierre Sierocki, Sandrine Warenghem, Florence Leroux, Nour Bou Karroum, Fabien Petit-Cancelier, Vincent Rodeschini, Didier Roche, Benoit Deprez, Rebecca Deprez-Poulain
Published in: European Journal of Medicinal Chemistry, Issue 280, 2024, Page(s) 116926, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2024.116926

Two bullets in the gun: combining immunotherapy with chemotherapy to defeat neuroblastoma by targeting adrenergic-mesenchymal plasticity

Author(s): Silvia D’Amico, Patrizia Tempora, Paula Gragera, Kamila Król, Ombretta Melaiu, Maria Antonietta De Ioris, Franco Locatelli, Doriana Fruci
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1268645

Discovery of New Nanomolar Selective IRAP Inhibitors

Author(s): Ben He, Nour Bou Karroum, Ronan Gealageas, François-Xavier Mauvais, Sandrine Warenghem, Matthieu Roignant, Nicolas Kraupner, Bao Vy Lam, Nathalie Azaroual, Vincent Ultré, Alexandre Rech, Laetitia Lesire, Cyril Couturier, Florence Leroux, Peter van Endert, Benoit Deprez, Rebecca Deprez-Poulain
Published in: Journal of Medicinal Chemistry, Issue 68, 2025, Page(s) 4168-4195, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c01744

A Systematic Review of Deep Learning Methodologies Used in the Drug Discovery Process with Emphasis on In Vivo Validation

Author(s): Nikoletta-Maria Koutroumpa, Konstantinos D. Papavasileiou, Anastasios G. Papadiamantis, Georgia Melagraki, Antreas Afantitis
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 6573, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24076573

Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor

Author(s): Anastasia Mpakali, Galateia Georgaki, Alberto Buson, Alison D. Findlay, Jonathan S. Foot, Francois‐Xavier Mauvais, Peter van Endert, Petros Giastas, Dieter W. Hamprecht, Efstratios Stratikos
Published in: Protein Science, Issue 33, 2024, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.5151

Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)

Author(s): Aroosha Raja, Jonas J. W. Kuiper
Published in: Genes & Immunity, Issue 24, 2023, Page(s) 295-302, ISSN 1476-5470
Publisher: Nature
DOI: 10.1038/s41435-023-00225-8

Discovery of Novel Allosteric Inhibitor Hits for Insulin-Regulated Aminopeptidase Provides Insights on Enzymatic Mechanism

Author(s): Galateia Georgaki, Nikoletta-Maria Koutroumpa, Panagiotis Lagarias, Antreas Afantitis, Athanasios Papakyriakou, Efstratios Stratikos
Published in: ACS Omega, Issue 10, 2025, Page(s) 17960-17972, ISSN 2470-1343
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsomega.5c01169

ERAP1 Activity Modulates the Immunopeptidome but Also Affects the Proteome, Metabolism, and Stress Responses in Cancer Cells

Author(s): Martha Nikopaschou, Martina Samiotaki, Elli-Anna Stylianaki, Kamila Król, Paula Gragera, Aroosha Raja, Vassilis Aidinis, Angeliki Chroni, Doriana Fruci, George Panayotou, Efstratios Stratikos
Published in: Molecular & Cellular Proteomics, Issue 24, 2025, Page(s) 100964, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2025.100964

Titania: an integrated tool for in silico molecular property prediction and NAM-based modeling

Author(s): Nikoletta-Maria Koutroumpa, Maria Antoniou, Dimitra-Danai Varsou, Konstantinos D. Papavasileiou, Nikolaos K. Sidiropoulos, Christoforos Kyprianou, Andreas Tsoumanis, Haralambos Sarimveis, Iseult Lynch, Georgia Melagraki, Antreas Afantitis
Published in: Molecular Diversity, 2025, ISSN 1381-1991
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11030-025-11196-5

A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors

Author(s): Paolo Romania, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Doriana Fruci
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1537876

Prediction of blood–brain barrier and Caco-2 permeability through the Enalos Cloud Platform: combining contrastive learning and atom-attention message passing neural networks

Author(s): Nikoletta-Maria Koutroumpa, Andreas Tsoumanis, Haralambos Sarimveis, Iseult Lynch, Georgia Melagraki, Antreas Afantitis
Published in: Journal of Cheminformatics, Issue 17, 2025, ISSN 1758-2946
Publisher: Chemistry Central
DOI: 10.1186/s13321-025-01007-2

An untargeted metabolomic study using MALDI-mass spectrometry imaging reveals region-specific biomarkers associated with bowel inflammation

Author(s): Adele Ponzoni, Silvia Speca, Matthew Hartle, Amandine Gerstenberg, Aurore Tomezyk, Victor Senechal, Shane Karnik, Laurent Dubuquoy, David Launay, Rebecca Deprez-Poulain, Mathieu Gaudin, Corinne Ramos, Benoit Deprez
Published in: Metabolomics, Issue 21, 2025, ISSN 1573-3890
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11306-024-02200-4

Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1

Author(s): Ioannis Temponeras, Martina Samiotaki, Despoina Koumantou, Martha Nikopaschou, Jonas J.W. Kuiper, George Panayotou, Efstratios Stratikos
Published in: European Journal of Immunology, Issue 53, 2023, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350449

Other (1)

ERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytes

Author(s): Martha Nikopaschou, Martina Samiotaki, Anna Kanavou, Nikos Angelis, Ourania Tsitsilonis, George Panayotou, Efstratios Stratikos
Published in: bioRxiv - The preprint server for biology, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.05.08.652898