Skip to main content

PI3K/PTEN-related monogenic disease to understand cancer

Project description

New therapeutic targets for rare disorders and cancer

Phosphoinositide 3-kinase (PI3K) signalling is a key pathway that regulates cell growth, metabolism, and survival. Phosphatase and tensin homolog (PTEN) serves as a negative regulator of the pathway and has a tumour-suppressive role. The scope of the EU-funded PIPgen project is to exploit existing knowledge on the involvement of PI3K/PTEN in cancer to understand the implication of the pathway in monogenic rare diseases, such as overgrowth syndromes, primary immunodeficiencies and cognitive deficiencies. Conversely, information on PI3K in rare diseases will be fed back to cancer. The generated basic science results will lay the foundation for the design of novel therapies for the numerous rare diseases that affect millions of citizens across Europe.

Coordinator

FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Net EU contribution
€ 501 809,76
Address
Carretera De Can Ruti Cami De Les Escoles S/n
08916 Badalona
Spain

See on map

Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00

Participants (10)

UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 606 345,12
Address
Gower Street
WC1E 6BT London

See on map

Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 549 604,08
Address
Rue De Tolbiac 101
75654 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 606 345,12
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

See on map

Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITE PARIS CITE
France
Net EU contribution
€ 274 802,04
Address
85 Bd Saint Germain
75006 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 265 619,88
Address
Dr Molewaterplein 40
3015 GD Rotterdam

See on map

Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STICHTING VUMC
Netherlands
Net EU contribution
€ 265 619,88
Address
De Boelelaan 1117
1081 HV Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 265 619,88
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

See on map

Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
Net EU contribution
€ 250 904,88
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya

See on map

Region
Noreste País Vasco Bizkaia
Activity type
Research Organisations
Other funding
€ 0,00
KITHER BIOTECH SRL
Italy
Net EU contribution
€ 261 499,68
Address
Via Nizza 52
10126 Torino

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Piemonte Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
QUANTITATIVE GENOMIC MEDICINE LABORATORIES SL
Spain
Net EU contribution
€ 250 904,88
Address
Calle Joan Xxiii 10
08950 Esplugues Del Llobregat

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00