Perspectives For Future Innovation in Tendon Repair

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Awarding 15 double PhD degrees

Double doctoral degree certificates (M44 or M48 in cases of authorized extension).

Communication products (radio/TV interview, journal articles, social networks post, etc.)

Articles, interviews on local, national and international media

OpenAIRE repository of dissemination products

30 publications on JCR and/or WoS journals and 30 short communications on OpenAIRE

P4 FIT website and social

Project website and interactive communication and dissemination tools

EURAXESS advertisement of vacancies

Starts M2 ends M3

Catalogue and teaching materials on e-platform

Relevant materials to be open on e-platform

Integrated set of preclinical and clinical tendon healing screening data

Integrated set of preclinical and clinical tendon healing screening data.

AI solutions for tendons healthcare

AI solutions for tendons healthcare by providing database and digitalized service to facilitate personalized clinical diagnosis and therapeutical approach solutions.

Publications

Impact of morphological features and chemical composition of tendon biomimetic scaffolds on immune recognition via Toll-like receptors

Author(s): Sara Gil-Cantero, Francesco Iorio, Irem Unalan, Fatih Kurtuldu, Sarojinidevi Künig, Claus Wenhardt, Veronica Pinnaro′, Katharina Aigner-Radakovics, Peter Steinberger, Aldo R. Boccaccini, Johannes Stöckl
Published in: Biomaterials Science, Issue 12, 2024, Page(s) 4695-4712, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4bm00147h

Unraveling the link: locomotor activity exerts a dual role in predicting Achilles tendon healing and boosting regeneration in mice

Author(s): Melisa Faydaver, Mohammad El Khatib, Valentina Russo, Mara Rigamonti, Marcello Raspa, Oriana Di Giacinto, Paolo Berardinelli, Annunziata Mauro, Ferdinando Scavizzi, Fabrizio Bonaventura, Valentina Mastrorilli, Luca Valbonetti, Barbara Barboni
Published in: Frontiers in Veterinary Science, Issue 10, 2023, ISSN 2297-1769
Publisher: Frontiers Media SA
DOI: 10.3389/fvets.2023.1281040

In Vitro Study of the Anti-inflammatory and Antifibrotic Activity of Tannic Acid-Coated Curcumin-Loaded Nanoparticles in Human Tenocytes

Author(s): Giuseppina Molinaro, Flavia Fontana, Rubén Pareja Tello, Shiqi Wang, Sandra López Cérda, Giulia Torrieri, Alexandra Correia, Eero Waris, Jouni T. Hirvonen, Goncalo Barreto, Hélder A. Santos
Published in: ACS Applied Materials & Interfaces, Issue 15, 2023, Page(s) 23012-23023, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.3c05322

<scp>ColMA</scp>‐based bioprinted <scp>3D</scp> scaffold allowed to study tenogenic events in human tendon stem cells

Author(s): Giacomo Cortella, Erwin Pavel Lamparelli, Maria Camilla Ciardulli, Joseph Lovecchio, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta
Published in: Bioengineering & Translational Medicine, Issue 10, 2025, ISSN 2380-6761
Publisher: John Wiley and Sons Inc
DOI: 10.1002/btm2.10723

Development of siRNA and Budesonide Dual‐Loaded Hybrid Lipid–Polymer Nanoparticles by Microfluidics Technology as a Platform for Dual Drug Delivery to Macrophages: An In Vitro Mechanistic Study

Author(s): Sandra López Cerdá, Flavia Fontana, Shiqi Wang, Alexandra Correia, Giuseppina Molinaro, Rubén Pareja Tello, Jouni Hirvonen, Christian Celia, Goncalo Barreto, Hélder A. Santos
Published in: Advanced Therapeutics, Issue 6, 2023, Page(s) 1-16, ISSN 2366-3987
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adtp.202300048

Assessing the functional potential of conditioned media derived from amniotic epithelial stem cells engineered on 3D biomimetic scaffolds: An in vitro model for tendon regeneration

Author(s): Valentina Russo, Giuseppe Prencipe, Annunziata Mauro, Mohammad El Khatib, Arlette A. Haidar-Montes, Nico Cambise, Maura Turriani, Johannes Stöckl, Peter Steinberger, Loreto Lancia, Matthias Schnabelrauch, Paolo Berardinelli, Barbara Barboni
Published in: Materials Today Bio, Issue 25, 2024, Page(s) 101001, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2024.101001

Unveiling the immunomodulatory shift: Epithelial-mesenchymal transition Alters immune mechanisms of amniotic epithelial cells

Author(s): Valeria Di Lollo, Angelo Canciello, Alessia Peserico, Massimiliano Orsini, Valentina Russo, Adrián Cerveró-Varona, Beatrice Dufrusine, Mohammad El Khatib, Valentina Curini, Annunziata Mauro, Paolo Berardinelli, Cathy Tournier, Massimo Ancora, Cesare Cammà, Enrico Dainese, Luana Fiorella Mincarelli, Barbara Barboni
Published in: iScience, Issue 26, 2024, Page(s) 107582, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2023.107582

Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers

Author(s): Florencia Diaz, Leander Zimmermann, Tina P. Dale, Nicholas R. Forsyth, Aldo R. Boccaccini
Published in: Carbohydrate Polymer Technologies and Applications, Issue 7, 2024, Page(s) 100447, ISSN 2666-8939
Publisher: Elsevier
DOI: 10.1016/j.carpta.2024.100447

Graphene oxide accelerates TGFβ-mediated epithelial-mesenchymal transition and stimulates pro-inflammatory immune response in amniotic epithelial cells

Author(s): Adrian Cerverò-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Published in: Materials Today Bio, Issue 22, 2023, Page(s) 100758, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2023.100758

Mechanobiological Strategies to Enhance Ovine (Ovis aries) Adipose-Derived Stem Cells Tendon Plasticity for Regenerative Medicine and Tissue Engineering Applications

Author(s): Arlette A. Haidar-Montes, Annunziata Mauro, Mohammad El Khatib, Giuseppe Prencipe, Laura Pierdomenico, Umberto Tosi, Guy Wouters, Adrián Cerveró-Varona, Paolo Berardinelli, Valentina Russo, Barbara Barboni
Published in: Animals, Issue 14, 2025, Page(s) 2233, ISSN 2076-2615
Publisher: MDPI
DOI: 10.3390/ani14152233

Stem-Cell-Driven Chondrogenesis: Perspectives on Amnion-Derived Cells

Author(s): Ludovica Sulcanese, Giuseppe Prencipe, Angelo Canciello, Adrián Cerveró-Varona, Monia Perugini, Annunziata Mauro, Valentina Russo, Barbara Barboni
Published in: Cells, Issue 13, 2024, Page(s) 744, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells13090744

Predictive Neuromarker Patterns for Calcification Metaplasia in Early Tendon Healing

Author(s): Melisa Faydaver, Valeria Festinese, Oriana Di Giacinto, Mohammad El Khatib, Marcello Raspa, Ferdinando Scavizzi, Fabrizio Bonaventura, Valentina Mastrorilli, Paolo Berardinelli, Barbara Barboni, Valentina Russo
Published in: Veterinary Sciences, Issue 11, 2025, Page(s) 441, ISSN 2306-7381
Publisher: MDPI
DOI: 10.3390/vetsci11090441

Wearable approaches for non-invasive monitoring of tendons: A scoping review

Author(s): Halldór Kárason, Pierluigi Ritrovato, Nicola Maffulli, Aldo R. Boccaccini, Francesco Tortorella
Published in: Internet of Things, Issue 26, 2024, Page(s) 101199, ISSN 2542-6605
Publisher: Elsevier
DOI: 10.1016/j.iot.2024.101199

Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide and Serpine1 siRNA Lipid–Polymer Nanoparticles Targeting Macrophage Dysregulation in Tendinopathy

Author(s): Sandra López-Cerdá, Giuseppina Molinaro, Rubén Pareja Tello, Alexandra Correia, Sarojinidevi Künig, Peter Steinberger, Michael Jeltsch, Jouni T. Hirvonen, Goncalo Barreto, Johannes Stöckl, Hélder A. Santos
Published in: ACS Applied Materials & Interfaces, Issue 16, 2024, Page(s) 18643-18657, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c02363

Biomimetic Platelet‐Cloaked Nanoparticles for the Delivery of Anti‐Inflammatory Curcumin in the Treatment of Atherosclerosis

Author(s): Flavia Fontana, Giuseppina Molinaro, Sofia Moroni, Giulia Pallozzi, Mónica P. A. Ferreira, Rubén Pareja Tello, Khalil Elbadri, Giulia Torrieri, Alexandra Correia, Marianna Kemell, Luca Casettari, Christian Celia, Hélder A. Santos
Published in: Advanced Healthcare Materials, Issue 13, 2024, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302074

Electrospun poly(ε‐caprolactone)/poly(glycerol sebacate) aligned fibers fabricated with benign solvents for tendon tissue engineering

Author(s): Francesco Iorio, Mohammad El Khatib, Natalie Wöltinger, Maura Turriani, Oriana Di Giacinto, Annunziata Mauro, Valentina Russo, Barbara Barboni, Aldo R. Boccaccini
Published in: Journal of Biomedical Materials Research Part A, Issue 113, 2025, ISSN 1549-3296
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jbm.a.37794

Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential

Author(s): Marta Clerici, Vera Citro, Amy L. Byrne ,Tina P. Dale, Aldo R. Boccaccini, Giovanna Della Porta, Nicola Maffulli, and Nicholas R. Forsyth
Published in: International Journal of Molecular Sciences, Issue 24(20), 2023, Page(s) 15107, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015107

Amniotic Epithelial Cell Microvesicles Uptake Inhibits PBMCs and Jurkat Cells Activation by Inducing Mitochondria-Dependent Apoptosis

Author(s): Adrián Cerveró-Varona, Giuseppe Prencipe, Alessia Peserico, Angelo Canciello, Andrew H. House, Hélder A. Santos, Monia Perugini, Ludovica Sulcanese, Chika Takano, Toshio Miki, Annamaria Iannetta, Valentina Russo, Mauro Mattioli, Barbara Barboni
Published in: iScience, 2025, Page(s) 111830, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2025.111830

Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration

Author(s): Valentina Russo, Mohammad El Khatib, Giuseppe Prencipe, Maria Rita Citeroni, Melisa Faydaver, Annunziata Mauro, Paolo Berardinelli, Adrián Cerveró-Varona, Arlette A. Haidar-Montes, Maura Turriani, Oriana Di Giacinto, Marcello Raspa, Ferdinando Scavizzi, Fabrizio Bonaventura, Johannes Stöckl and Barbara Barboni
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11030434

Development of Amniotic Epithelial Stem Cells Secretome-Loaded In Situ Inverse Electron Demand Diels–Alder-Cross-Linked Hydrogel as a Potential Immunomodulatory Therapeutical Tool

Author(s): Rubén Pareja Tello, Adrián Cerveró-Varona, Giuseppe Prencipe, Giuseppina Molinaro, Veronica Pinnarò, Arlette Alina Haidar-Montes, Alexandra Correia, Sami Hietala, Johannes Stöckl, Jouni Hirvonen, Goncalo Barreto, Valentina Russo, Barbara Barboni, Hélder A. Santos
Published in: ACS Applied Materials & Interfaces, Issue 17, 2025, Page(s) 2977-2990, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c16659

Amphiregulin orchestrates the paracrine immune-suppressive function of amniotic-derived cells through its interplay with COX-2/PGE2/EP4 axis

Author(s): Giuseppe Prencipe, Adrián Cerveró-Varona, Monia Perugini, Ludovica Sulcanese, Annamaria Iannetta, Arlette Alina Haidar-Montes, Johannes Stöckl, Angelo Canciello, Paolo Berardinelli, Valentina Russo, Barbara Barboni
Published in: iScience, Issue 27, 2024, Page(s) 110508, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2024.110508

Oxidized Phospholipids Regulate Tenocyte Function via Induction of Amphiregulin in Dendritic Cells

Author(s): Veronica Pinnarò, Stefanie Kirchberger, Sarojinidevi Künig, Sara Gil Cantero, Maria Camilla Ciardulli, Giovanna Della Porta, Stephan Blüml, Adelheid Elbe-Bürger, Valery Bochkov, Johannes Stöckl
Published in: International Journal of Molecular Sciences, Issue 25, 2024, Page(s) 7600, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25147600

Fibrin Scaffolds Perfused with Transforming Growth Factor-β1 as an In Vitro Model to Study Healthy and Tendinopathic Human Tendon Stem/Progenitor Cells

Author(s): Maria Camilla Ciardulli, Joseph Lovecchio, Ornella Parolini, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta
Published in: International Journal of Molecular Sciences, Issue 25, 2025, Page(s) 9563, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25179563

Mammal comparative tendon biology: advances in regulatory mechanisms through a computational modeling

Author(s): Alessia Peserico, Barbara Barboni, Valentina Russo, Nicola Bernabò, Mohammad El Khatib, Giuseppe Prencipe, Adrián Cerveró-Varona, Arlette Alina Haidar-Montes, Melisa Faydaver, Maria Rita Citeroni, Paolo Berardinelli, Annunziata Mauro
Published in: Frontiers in Veterinary Science, Issue 10, 2023, ISSN 2297-1769
Publisher: Frontiers Media SA
DOI: 10.3389/fvets.2023.1175346

Tendon 3D Scaffolds Establish a Tailored Microenvironment Instructing Paracrine Mediated Regenerative Amniotic Epithelial Stem Cells Potential

Author(s): Valentina Russo, Mohammad El Khatib, Giuseppe Prencipe, Annunziata Mauro, Oriana Di Giacinto, Arlette A. Haidar-Montes, Fanny Pulcini, Beatrice Dufrusine, Adrián Cerveró-Varona, Melisa Faydaver, Chiara Di Berardino, Enrico Dainese, Paolo Berardinelli, Matthias Schnabelrauch, Barbara Barboni
Published in: Biomedicines, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10102578

Stem Cells from Healthy and Tendinopathic Human Tendons: Morphology, Collagen and Cytokines Expression and Their Response to T3 Thyroid Hormone

Author(s): Maria Camilla Ciardulli, Pasqualina Scala, Valentina Giudice, Antonietta Santoro, Carmine Selleri, Francesco Oliva, Nicola Maffulli, Giovanna Della Porta
Published in: Cells, 2022, Page(s) 11(16):2545, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11162545

Scaffold-Mediated Immunoengineering as Innovative Strategy for Tendon Regeneration

Author(s): Valentina Russo, Mohammad El Khatib, Giuseppe Prencipe, Adrián Cerveró-Varona, Maria Rita Citeroni, Annunziata Mauro, Paolo Berardinelli, Melisa Faydaver, Arlette A. Haidar-Montes, Maura Turriani, Oriana Di Giacinto, Marcello Raspa, Ferdinando Scavizzi, Fabrizio Bonaventura, Liliana Liverani, Aldo R. Boccaccini, Barbara Barboni
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11020266

Hybrid lipid nanoparticles derived from human mesenchymal stem cell extracellular vesicles by microfluidic-sonication for collagen I mRNA delivery to human tendon progenitor stem cells

Author(s): Ruben Pareja Tello, Erwin Pavel Lamparelli, Maria Camilla Ciardulli, Jouni Hirvonen, Goncalo Barreto, Nicola Maffulli, Giovanna Della Porta, Hélder A. Santos
Published in: Biomaterials Science, 2025, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4bm01405g

Beyond pixel: Superpixel-based MRI segmentation through traditional machine learning and graph convolutional network

Author(s): Zakia Khatun, Halldór Jónsson, Mariella Tsirilaki, Nicola Maffulli, Francesco Oliva, Pauline Daval, Francesco Tortorella, Paolo Gargiulo
Published in: Computer Methods and Programs in Biomedicine, Issue 256, 2024, Page(s) 108398, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108398

Aligned Ice Templated Biomaterial Strategies for the Musculoskeletal System

Author(s): Florencia Diaz, Nicholas Forsyth, Aldo R. Boccaccini
Published in: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202203205

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair

Author(s): Vera Citro, Marta Clerici, Aldo R. Boccaccini, Giovanna Della Porta, Nicola Maffulli, and Nicholas R. Forsyth
Published in: Journal of Tissue Engineering, 2023, ISSN 2041-7314
Publisher: SAGE
DOI: 10.1177/20417314231196275

Antifibrotic and Pro-regenerative Effects of SMAD3 siRNA and Collagen I mRNA-Loaded Lipid Nanoparticles in Human Tenocytes

Author(s): Sandra López-Cerdá, Giuseppina Molinaro, Rubén Pareja Tello, Alexandra Correia, Eero Waris, Jouni Hirvonen, Goncalo Barreto, Hélder A. Santos
Published in: ACS Applied Nano Materials, Issue 7, 2024, Page(s) 17736-17747, ISSN 2574-0970
Publisher: American Chemical Society
DOI: 10.1021/acsanm.4c02996

Fabrication of hydrogel microspheres via microfluidics using inverse electron demand Diels–Alder click chemistry-based tetrazine-norbornene for drug delivery and cell encapsulation applications

Author(s): Rubén Pareja Tello, Shiqi Wang, Flavia Fontana, Alexandra Correia, Giuseppina Molinaro, Sandra López Cerdà, Sami Hietala, Jouni Hirvonen, Goncalo Barreto, Hélder A. Santos
Published in: Biomaterials Science, Issue 11, 2024, Page(s) 4972-4984, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3bm00292f

Assessing neuromuscular system via patellar tendon reflex analysis using EMG in healthy individuals

Author(s): Zakia Khatun, Sara Kristinsdóttir, Arndís Thóra Thórisdóttir, Linda Björk Halldórsdóttir, Francesco Tortorella, Paolo Gargiulo, Thordur Helgason
Published in: Frontiers in Neurology, Issue 15, 2025, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2024.1522121

“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes

Author(s): Angelo Canciello, Adrián Cerveró-Varona, Alessia Peserico, Annunziata Mauro, Valentina Russo, Andrea Morrione, Antonio Giordano, Barbara Barboni
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1038841

Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds

Author(s): Muhammad Nadeem Hafeez, Nicola d’Avanzo, Valentina Russo, Luisa Di Marzio, Felisa Cilurzo, Donatella Paolino, Massimo Fresta, Barbara Barboni, Hélder A. Santos, Christian Celia
Published in: Stem Cells International, Issue 1488829, 2021, Page(s) 23, ISSN 1687-9678
Publisher: Hindawi
DOI: 10.1155/2021/1488829

Flexible AgNW/PDMS nanocomposite for strain and pressure sensing

Author(s): Halldór Kárason, Pierluigi Ritrovato, Nicola Maffulli, Francesco Tortorella, Aldo R. Boccaccini
Published in: Materials Letters, Issue 377, 2024, Page(s) 137456, ISSN 0167-577X
Publisher: Elsevier BV
DOI: 10.1016/j.matlet.2024.137456

Amniotic Membrane and Amniotic Epithelial Cell Culture

Author(s): Angelo Canciello, Adrian Cerverò-Varona, Maura Turriani, Valentina Russo, Barbara Barboni
Published in: Methods in Molecular Biology, Epithelial Cell Culture, 2023, Page(s) 135-149
Publisher: Springer US
DOI: 10.1007/978-1-0716-3609-1_13

Generative Data Augmentation of Human Biomechanics

Author(s): Halldór Kárason, Pierluigi Ritrovato, Nicola Maffulli, Francesco Tortorella
Published in: Lecture Notes in Computer Science, Image Analysis and Processing - ICIAP 2023 Workshops, 2024, Page(s) 482-493
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-51023-6_40

The Role of Muscle and Tendon in Predicting Cartilage Degeneration and Tendinopathy

Author(s): Zakia Khatun, Mariella Tsirilaki, Alessia Lindemann, Francesco Tortorella, Nicola Maffulli, Halldor Jonsson, Paolo Gargiulo
Published in: 2022 IEEE International Conference on Metrology for Extended Reality, Artificial Intelligence and Neural Engineering (MetroXRAINE), 2022
Publisher: IEEE
DOI: 10.1109/metroxraine54828.2022.9967653

Searching for OpenAIRE data...

Deliverables

Publications

Share this page Share this page on social networks

Download Download the content of the page