Perspectives For Future Innovation in Tendon Repair

Información del proyecto

P4 FIT

Identificador del acuerdo de subvención: 955685

DOI

10.3030/955685

Proyecto cerrado

Fecha de la firma de la CE 3 Septiembre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 043 040,48

Aportación de la UE

€ 4 043 040,48

Coordinado por

HELSINGIN YLIOPISTO
Finland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Awarding 15 double PhD degrees

Double doctoral degree certificates (M44 or M48 in cases of authorized extension).

Communication products (radio/TV interview, journal articles, social networks post, etc.)

Articles, interviews on local, national and international media

OpenAIRE repository of dissemination products

30 publications on JCR and/or WoS journals and 30 short communications on OpenAIRE

Other (4)

P4 FIT website and social

Project website and interactive communication and dissemination tools

EURAXESS advertisement of vacancies

Starts M2 ends M3

Catalogue and teaching materials on e-platform

Relevant materials to be open on e-platform

Integrated set of preclinical and clinical tendon healing screening data

Integrated set of preclinical and clinical tendon healing screening data.

Open Research Data Pilot (1)

AI solutions for tendons healthcare

AI solutions for tendons healthcare by providing database and digitalized service to facilitate personalized clinical diagnosis and therapeutical approach solutions.

Publicaciones

Peer reviewed articles (37)

Impact of morphological features and chemical composition of tendon biomimetic scaffolds on immune recognition <i>via</i> Toll-like receptors

Autores: Sara Gil-Cantero, Francesco Iorio, Irem Unalan, Fatih Kurtuldu, Sarojinidevi Künig, Claus Wenhardt, Veronica Pinnaro′, Katharina Aigner-Radakovics, Peter Steinberger, Aldo R. Boccaccini, Johannes Stöckl
Publicado en: Biomaterials Science, Edición 12, 2024, Página(s) 4695-4712, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d4bm00147h

Unraveling the link: locomotor activity exerts a dual role in predicting Achilles tendon healing and boosting regeneration in mice

Autores: Melisa Faydaver, Mohammad El Khatib, Valentina Russo, Mara Rigamonti, Marcello Raspa, Oriana Di Giacinto, Paolo Berardinelli, Annunziata Mauro, Ferdinando Scavizzi, Fabrizio Bonaventura, Valentina Mastrorilli, Luca Valbonetti, Barbara Barboni
Publicado en: Frontiers in Veterinary Science, Edición 10, 2023, ISSN 2297-1769
Editor: Frontiers Media SA
DOI: 10.3389/fvets.2023.1281040

In Vitro Study of the Anti-inflammatory and Antifibrotic Activity of Tannic Acid-Coated Curcumin-Loaded Nanoparticles in Human Tenocytes

Autores: Giuseppina Molinaro, Flavia Fontana, Rubén Pareja Tello, Shiqi Wang, Sandra López Cérda, Giulia Torrieri, Alexandra Correia, Eero Waris, Jouni T. Hirvonen, Goncalo Barreto, Hélder A. Santos
Publicado en: ACS Applied Materials &amp; Interfaces, Edición 15, 2023, Página(s) 23012-23023, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.3c05322

<scp>ColMA</scp>‐based bioprinted <scp>3D</scp> scaffold allowed to study tenogenic events in human tendon stem cells

Autores: Giacomo Cortella, Erwin Pavel Lamparelli, Maria Camilla Ciardulli, Joseph Lovecchio, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta
Publicado en: Bioengineering &amp; Translational Medicine, Edición 10, 2025, ISSN 2380-6761
Editor: John Wiley and Sons Inc
DOI: 10.1002/btm2.10723

Development of siRNA and Budesonide Dual‐Loaded Hybrid Lipid–Polymer Nanoparticles by Microfluidics Technology as a Platform for Dual Drug Delivery to Macrophages: An In Vitro Mechanistic Study

Autores: Sandra López Cerdá, Flavia Fontana, Shiqi Wang, Alexandra Correia, Giuseppina Molinaro, Rubén Pareja Tello, Jouni Hirvonen, Christian Celia, Goncalo Barreto, Hélder A. Santos
Publicado en: Advanced Therapeutics, Edición 6, 2023, Página(s) 1-16, ISSN 2366-3987
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adtp.202300048

Assessing the functional potential of conditioned media derived from amniotic epithelial stem cells engineered on 3D biomimetic scaffolds: An in vitro model for tendon regeneration

Autores: Valentina Russo, Giuseppe Prencipe, Annunziata Mauro, Mohammad El Khatib, Arlette A. Haidar-Montes, Nico Cambise, Maura Turriani, Johannes Stöckl, Peter Steinberger, Loreto Lancia, Matthias Schnabelrauch, Paolo Berardinelli, Barbara Barboni
Publicado en: Materials Today Bio, Edición 25, 2024, Página(s) 101001, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2024.101001

Unveiling the immunomodulatory shift: Epithelial-mesenchymal transition Alters immune mechanisms of amniotic epithelial cells

Autores: Valeria Di Lollo, Angelo Canciello, Alessia Peserico, Massimiliano Orsini, Valentina Russo, Adrián Cerveró-Varona, Beatrice Dufrusine, Mohammad El Khatib, Valentina Curini, Annunziata Mauro, Paolo Berardinelli, Cathy Tournier, Massimo Ancora, Cesare Cammà, Enrico Dainese, Luana Fiorella Mincarelli, Barbara Barboni
Publicado en: iScience, Edición 26, 2024, Página(s) 107582, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2023.107582

Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers

Autores: Florencia Diaz, Leander Zimmermann, Tina P. Dale, Nicholas R. Forsyth, Aldo R. Boccaccini
Publicado en: Carbohydrate Polymer Technologies and Applications, Edición 7, 2024, Página(s) 100447, ISSN 2666-8939
Editor: Elsevier
DOI: 10.1016/j.carpta.2024.100447

Graphene oxide accelerates TGFβ-mediated epithelial-mesenchymal transition and stimulates pro-inflammatory immune response in amniotic epithelial cells

Autores: Adrian Cerverò-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Publicado en: Materials Today Bio, Edición 22, 2023, Página(s) 100758, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2023.100758

Mechanobiological Strategies to Enhance Ovine (Ovis aries) Adipose-Derived Stem Cells Tendon Plasticity for Regenerative Medicine and Tissue Engineering Applications

Autores: Arlette A. Haidar-Montes, Annunziata Mauro, Mohammad El Khatib, Giuseppe Prencipe, Laura Pierdomenico, Umberto Tosi, Guy Wouters, Adrián Cerveró-Varona, Paolo Berardinelli, Valentina Russo, Barbara Barboni
Publicado en: Animals, Edición 14, 2025, Página(s) 2233, ISSN 2076-2615
Editor: MDPI
DOI: 10.3390/ani14152233

Stem-Cell-Driven Chondrogenesis: Perspectives on Amnion-Derived Cells

Autores: Ludovica Sulcanese, Giuseppe Prencipe, Angelo Canciello, Adrián Cerveró-Varona, Monia Perugini, Annunziata Mauro, Valentina Russo, Barbara Barboni
Publicado en: Cells, Edición 13, 2024, Página(s) 744, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells13090744

Predictive Neuromarker Patterns for Calcification Metaplasia in Early Tendon Healing

Autores: Melisa Faydaver, Valeria Festinese, Oriana Di Giacinto, Mohammad El Khatib, Marcello Raspa, Ferdinando Scavizzi, Fabrizio Bonaventura, Valentina Mastrorilli, Paolo Berardinelli, Barbara Barboni, Valentina Russo
Publicado en: Veterinary Sciences, Edición 11, 2025, Página(s) 441, ISSN 2306-7381
Editor: MDPI
DOI: 10.3390/vetsci11090441

Wearable approaches for non-invasive monitoring of tendons: A scoping review

Autores: Halldór Kárason, Pierluigi Ritrovato, Nicola Maffulli, Aldo R. Boccaccini, Francesco Tortorella
Publicado en: Internet of Things, Edición 26, 2024, Página(s) 101199, ISSN 2542-6605
Editor: Elsevier
DOI: 10.1016/j.iot.2024.101199

Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide and Serpine1 siRNA Lipid–Polymer Nanoparticles Targeting Macrophage Dysregulation in Tendinopathy

Autores: Sandra López-Cerdá, Giuseppina Molinaro, Rubén Pareja Tello, Alexandra Correia, Sarojinidevi Künig, Peter Steinberger, Michael Jeltsch, Jouni T. Hirvonen, Goncalo Barreto, Johannes Stöckl, Hélder A. Santos
Publicado en: ACS Applied Materials &amp; Interfaces, Edición 16, 2024, Página(s) 18643-18657, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.4c02363

Biomimetic Platelet‐Cloaked Nanoparticles for the Delivery of Anti‐Inflammatory Curcumin in the Treatment of Atherosclerosis

Autores: Flavia Fontana, Giuseppina Molinaro, Sofia Moroni, Giulia Pallozzi, Mónica P. A. Ferreira, Rubén Pareja Tello, Khalil Elbadri, Giulia Torrieri, Alexandra Correia, Marianna Kemell, Luca Casettari, Christian Celia, Hélder A. Santos
Publicado en: Advanced Healthcare Materials, Edición 13, 2024, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302074

Electrospun poly(ε‐caprolactone)/poly(glycerol sebacate) aligned fibers fabricated with benign solvents for tendon tissue engineering

Autores: Francesco Iorio, Mohammad El Khatib, Natalie Wöltinger, Maura Turriani, Oriana Di Giacinto, Annunziata Mauro, Valentina Russo, Barbara Barboni, Aldo R. Boccaccini
Publicado en: Journal of Biomedical Materials Research Part A, Edición 113, 2025, ISSN 1549-3296
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jbm.a.37794

Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential

Autores: Marta Clerici, Vera Citro, Amy L. Byrne ,Tina P. Dale, Aldo R. Boccaccini, Giovanna Della Porta, Nicola Maffulli, and Nicholas R. Forsyth
Publicado en: International Journal of Molecular Sciences, Edición 24(20), 2023, Página(s) 15107, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015107

Amniotic Epithelial Cell Microvesicles Uptake Inhibits PBMCs and Jurkat Cells Activation by Inducing Mitochondria-Dependent Apoptosis

Autores: Adrián Cerveró-Varona, Giuseppe Prencipe, Alessia Peserico, Angelo Canciello, Andrew H. House, Hélder A. Santos, Monia Perugini, Ludovica Sulcanese, Chika Takano, Toshio Miki, Annamaria Iannetta, Valentina Russo, Mauro Mattioli, Barbara Barboni
Publicado en: iScience, 2025, Página(s) 111830, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2025.111830

Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration

Autores: Valentina Russo, Mohammad El Khatib, Giuseppe Prencipe, Maria Rita Citeroni, Melisa Faydaver, Annunziata Mauro, Paolo Berardinelli, Adrián Cerveró-Varona, Arlette A. Haidar-Montes, Maura Turriani, Oriana Di Giacinto, Marcello Raspa, Ferdinando Scavizzi, Fabrizio Bonaventura, Johannes Stöckl and Barbara Barboni
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11030434

Development of Amniotic Epithelial Stem Cells Secretome-Loaded <i>In Situ</i> Inverse Electron Demand Diels–Alder-Cross-Linked Hydrogel as a Potential Immunomodulatory Therapeutical Tool

Autores: Rubén Pareja Tello, Adrián Cerveró-Varona, Giuseppe Prencipe, Giuseppina Molinaro, Veronica Pinnarò, Arlette Alina Haidar-Montes, Alexandra Correia, Sami Hietala, Johannes Stöckl, Jouni Hirvonen, Goncalo Barreto, Valentina Russo, Barbara Barboni, Hélder A. Santos
Publicado en: ACS Applied Materials &amp; Interfaces, Edición 17, 2025, Página(s) 2977-2990, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.4c16659

Amphiregulin orchestrates the paracrine immune-suppressive function of amniotic-derived cells through its interplay with COX-2/PGE2/EP4 axis

Autores: Giuseppe Prencipe, Adrián Cerveró-Varona, Monia Perugini, Ludovica Sulcanese, Annamaria Iannetta, Arlette Alina Haidar-Montes, Johannes Stöckl, Angelo Canciello, Paolo Berardinelli, Valentina Russo, Barbara Barboni
Publicado en: iScience, Edición 27, 2024, Página(s) 110508, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2024.110508

Oxidized Phospholipids Regulate Tenocyte Function via Induction of Amphiregulin in Dendritic Cells

Autores: Veronica Pinnarò, Stefanie Kirchberger, Sarojinidevi Künig, Sara Gil Cantero, Maria Camilla Ciardulli, Giovanna Della Porta, Stephan Blüml, Adelheid Elbe-Bürger, Valery Bochkov, Johannes Stöckl
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, Página(s) 7600, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25147600

Fibrin Scaffolds Perfused with Transforming Growth Factor-β1 as an In Vitro Model to Study Healthy and Tendinopathic Human Tendon Stem/Progenitor Cells

Autores: Maria Camilla Ciardulli, Joseph Lovecchio, Ornella Parolini, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 9563, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25179563

Mammal comparative tendon biology: advances in regulatory mechanisms through a computational modeling

Autores: Alessia Peserico, Barbara Barboni, Valentina Russo, Nicola Bernabò, Mohammad El Khatib, Giuseppe Prencipe, Adrián Cerveró-Varona, Arlette Alina Haidar-Montes, Melisa Faydaver, Maria Rita Citeroni, Paolo Berardinelli, Annunziata Mauro
Publicado en: Frontiers in Veterinary Science, Edición 10, 2023, ISSN 2297-1769
Editor: Frontiers Media SA
DOI: 10.3389/fvets.2023.1175346

Tendon 3D Scaffolds Establish a Tailored Microenvironment Instructing Paracrine Mediated Regenerative Amniotic Epithelial Stem Cells Potential

Autores: Valentina Russo, Mohammad El Khatib, Giuseppe Prencipe, Annunziata Mauro, Oriana Di Giacinto, Arlette A. Haidar-Montes, Fanny Pulcini, Beatrice Dufrusine, Adrián Cerveró-Varona, Melisa Faydaver, Chiara Di Berardino, Enrico Dainese, Paolo Berardinelli, Matthias Schnabelrauch, Barbara Barboni
Publicado en: Biomedicines, 2022, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines10102578

Stem Cells from Healthy and Tendinopathic Human Tendons: Morphology, Collagen and Cytokines Expression and Their Response to T3 Thyroid Hormone

Autores: Maria Camilla Ciardulli, Pasqualina Scala, Valentina Giudice, Antonietta Santoro, Carmine Selleri, Francesco Oliva, Nicola Maffulli, Giovanna Della Porta
Publicado en: Cells, 2022, Página(s) 11(16):2545, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11162545

Scaffold-Mediated Immunoengineering as Innovative Strategy for Tendon Regeneration

Autores: Valentina Russo, Mohammad El Khatib, Giuseppe Prencipe, Adrián Cerveró-Varona, Maria Rita Citeroni, Annunziata Mauro, Paolo Berardinelli, Melisa Faydaver, Arlette A. Haidar-Montes, Maura Turriani, Oriana Di Giacinto, Marcello Raspa, Ferdinando Scavizzi, Fabrizio Bonaventura, Liliana Liverani, Aldo R. Boccaccini, Barbara Barboni
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11020266

Hybrid lipid nanoparticles derived from human mesenchymal stem cell extracellular vesicles by microfluidic-sonication for collagen I mRNA delivery to human tendon progenitor stem cells

Autores: Ruben Pareja Tello, Erwin Pavel Lamparelli, Maria Camilla Ciardulli, Jouni Hirvonen, Goncalo Barreto, Nicola Maffulli, Giovanna Della Porta, Hélder A. Santos
Publicado en: Biomaterials Science, 2025, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d4bm01405g

Beyond pixel: Superpixel-based MRI segmentation through traditional machine learning and graph convolutional network

Autores: Zakia Khatun, Halldór Jónsson, Mariella Tsirilaki, Nicola Maffulli, Francesco Oliva, Pauline Daval, Francesco Tortorella, Paolo Gargiulo
Publicado en: Computer Methods and Programs in Biomedicine, Edición 256, 2024, Página(s) 108398, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108398

Aligned Ice Templated Biomaterial Strategies for the Musculoskeletal System

Autores: Florencia Diaz, Nicholas Forsyth, Aldo R. Boccaccini
Publicado en: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Editor: World Scientific
DOI: 10.1002/adhm.202203205

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair

Autores: Vera Citro, Marta Clerici, Aldo R. Boccaccini, Giovanna Della Porta, Nicola Maffulli, and Nicholas R. Forsyth
Publicado en: Journal of Tissue Engineering, 2023, ISSN 2041-7314
Editor: SAGE
DOI: 10.1177/20417314231196275

Antifibrotic and Pro-regenerative Effects of SMAD3 siRNA and Collagen I mRNA-Loaded Lipid Nanoparticles in Human Tenocytes

Autores: Sandra López-Cerdá, Giuseppina Molinaro, Rubén Pareja Tello, Alexandra Correia, Eero Waris, Jouni Hirvonen, Goncalo Barreto, Hélder A. Santos
Publicado en: ACS Applied Nano Materials, Edición 7, 2024, Página(s) 17736-17747, ISSN 2574-0970
Editor: American Chemical Society
DOI: 10.1021/acsanm.4c02996

Fabrication of hydrogel microspheres <i>via</i> microfluidics using inverse electron demand Diels–Alder click chemistry-based tetrazine-norbornene for drug delivery and cell encapsulation applications

Autores: Rubén Pareja Tello, Shiqi Wang, Flavia Fontana, Alexandra Correia, Giuseppina Molinaro, Sandra López Cerdà, Sami Hietala, Jouni Hirvonen, Goncalo Barreto, Hélder A. Santos
Publicado en: Biomaterials Science, Edición 11, 2024, Página(s) 4972-4984, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d3bm00292f

Assessing neuromuscular system via patellar tendon reflex analysis using EMG in healthy individuals

Autores: Zakia Khatun, Sara Kristinsdóttir, Arndís Thóra Thórisdóttir, Linda Björk Halldórsdóttir, Francesco Tortorella, Paolo Gargiulo, Thordur Helgason
Publicado en: Frontiers in Neurology, Edición 15, 2025, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2024.1522121

“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes

Autores: Angelo Canciello, Adrián Cerveró-Varona, Alessia Peserico, Annunziata Mauro, Valentina Russo, Andrea Morrione, Antonio Giordano, Barbara Barboni
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.1038841

Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds

Autores: Muhammad Nadeem Hafeez, Nicola d’Avanzo, Valentina Russo, Luisa Di Marzio, Felisa Cilurzo, Donatella Paolino, Massimo Fresta, Barbara Barboni, Hélder A. Santos, Christian Celia
Publicado en: Stem Cells International, Edición 1488829, 2021, Página(s) 23, ISSN 1687-9678
Editor: Hindawi
DOI: 10.1155/2021/1488829

Flexible AgNW/PDMS nanocomposite for strain and pressure sensing

Autores: Halldór Kárason, Pierluigi Ritrovato, Nicola Maffulli, Francesco Tortorella, Aldo R. Boccaccini
Publicado en: Materials Letters, Edición 377, 2024, Página(s) 137456, ISSN 0167-577X
Editor: Elsevier BV
DOI: 10.1016/j.matlet.2024.137456

Book chapters (2)

Amniotic Membrane and Amniotic Epithelial Cell Culture

Autores: Angelo Canciello, Adrian Cerverò-Varona, Maura Turriani, Valentina Russo, Barbara Barboni
Publicado en: Methods in Molecular Biology, Epithelial Cell Culture, 2023, Página(s) 135-149
Editor: Springer US
DOI: 10.1007/978-1-0716-3609-1_13

Generative Data Augmentation of Human Biomechanics

Autores: Halldór Kárason, Pierluigi Ritrovato, Nicola Maffulli, Francesco Tortorella
Publicado en: Lecture Notes in Computer Science, Image Analysis and Processing - ICIAP 2023 Workshops, 2024, Página(s) 482-493
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-51023-6_40

Conference proceedings (1)

The Role of Muscle and Tendon in Predicting Cartilage Degeneration and Tendinopathy

Autores: Zakia Khatun, Mariella Tsirilaki, Alessia Lindemann, Francesco Tortorella, Nicola Maffulli, Halldor Jonsson, Paolo Gargiulo
Publicado en: 2022 IEEE International Conference on Metrology for Extended Reality, Artificial Intelligence and Neural Engineering (MetroXRAINE), 2022
Editor: IEEE
DOI: 10.1109/metroxraine54828.2022.9967653