Descripción del proyecto
Terapia con partículas personalizada
La terapia con partículas (TP) es un tipo de radioterapia que se dirige a los tumores con gran precisión y no afecta al tejido sano circundante. Sin embargo, la TP en su formato actual es lenta y carece de flexibilidad, lo que la hace inadecuada para los tratamientos personalizados. Para aprovechar todos los beneficios de la PT, se necesita una mayor optimización relacionada con los cambios en la anatomía o el movimiento de los órganos. El proyecto RAPTOR, financiado con fondos europeos, tiene como objetivo abordar estas limitaciones y hacer avanzar la TP para lograr su uso en tiempo real. El proyecto involucra a líderes industriales clave, lo que asegura la traducción rápida de los hallazgos en soluciones innovadoras y comercializables que se puedan implementar en la práctica clínica.
Objetivo
The Real-time Adaptive Particle Therapy Of CanceR (RAPTOR) consortium comprises world-class research institutes, non-academic particle therapy (PT) centres and industrial providers of PT equipment, offering a platform for intercultural, interdisciplinary and intersectoral training of early stage researchers (ESRs) in the field of medical physics with a focus on real-time adaptive PT. This comprehensive expertise and infrastructure is required to address and solve challenges in the clinical implementation of real-time adaptive PT.
PT is an advanced type of radiotherapy used to treat a constantly rising number of cancer patients. PT allows to target tumour with a high accuracy while sparing healthy surrounding tissue from dose. However, changes in anatomy or positioning and organ motion give rise to uncertainties which need to be further minimized to exploit the full benefits of PT. Adapting PT plans in real time has the potential to provide truly personalized treatments, allowing for better target control and less toxicity. A move towards wide clinical implementation of adaptive PT approaches is currently prohibited by (i) stepwise treatment workflows that are time-consuming and largely manual, (ii) the inflexibility of commercial PT equipment, and (iii) the wide range of PT equipment and protocols.
RAPTOR ESRs will conduct research projects at both academic and non-academic health care facilities which will sharpen their focus on clinical needs with respect to real-time adaptive PT. The active involvement of industry ensures that the transfer of industry-relevant skills is an integral part of individual ESR projects. This will guarantee rapid translation of clinical needs into innovative and marketable solutions.
RAPTOR aims to train a new generation of researchers, enabling a paradigm shift from treatment approaches that are manual and stepwise to those that are automatic and seamless, while assuring standardized clinical implementation of real-time adaptive PT.
Ámbito científico
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Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
5232 Villigen Psi
Suiza