Descripción del proyecto
Administración de nanomedicamentos personalizados en el microentorno tumoral
Hay muchas enfermedades con necesidades médicas insatisfechas, incluido el cáncer. La nanotecnología ha surgido como una solución prometedora para encapsular fármacos y aumentar su estabilidad y biodistribución. El equipo del proyecto ICARUS, financiado con fondos europeos, pretende mejorar la eficacia y el resultado terapéutico de nanomedicamentos antineoplásicos personalizados. Estos compuestos son biodegradables y tienen un gran perfil farmacocinético. En ICARUS, los investigadores planean desarrollar metodologías analíticas innovadoras de última generación que ayuden a dilucidar la distribución y el comportamiento de estos nanomedicamentos en el microentorno tumoral. Los resultados posibilitarán unos fármacos mejor tolerados en comparación con las modalidades de tratamiento convencionales.
Objetivo
Cristal Therapeutics (CT) is an innovative SME based in the Netherlands dedicated to the creation of the next generation of targeted nanomedicines (NM). CT has developed CriPec, a nanoparticle technology that can entrap a wide range of drugs, transforming them into custom-made NM. CriPec-based products have demonstrated excellent pharmacokinetics and tumour accumulation as well as highly improved safety, both in laboratory and patient settings. However, the full therapeutic potential of CriPec has not been obtained due to a lack of understanding of its tumour microenvironment (TME) microdistribution and behaviour, hindered by the lack of highly specific (bio)analytical expertise within Cristal Therapeutics.
ICARUS will enable CT to solidify its position as an innovative SME and provide them a competitive edge through hiring an Innovation Associate (IA). The envisioned IA will develop and implement state-of-art (bio)analytical methodologies (including advanced MALDI-techniques) that have not been exploited in the field of NM until now, and that will provide CT with essential insights that will guide the composition optimisation of all CriPec-based products.
Furthermore, the ICARUS project is heavily focused around the training of the IA, thereby greatly improving his/her career development. A training programme tailored to his/her specific needs and personal career development plan will be developed, allowing the IA to:
• Gain novel skills and experience on every aspect of the development of nanoparticles, encompassing the required multidisciplinary expertise from several fields;
• Gain innovation and business related skills in a multidisciplinary setting.
Ámbito científico
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-INNOSUP-2020-02
Régimen de financiación
CSA-LSP - Coordination and support action Lump sumCoordinador
6229 EV MAASTRICHT
Países Bajos
Organización definida por ella misma como pequeña y mediana empresa (pyme) en el momento de la firma del acuerdo de subvención.