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Disruptive materials, technologies & approaches to unravel the role of Astrocytes in brain function and dysfunction: towards to Glial interfaces

Objective

The past four decades demonstrated that non-neuronal cells, called astrocytesare emerging as crucial players for brain function & dysfunction. A major obstacle of previous and current initiatives on Neurotechnologiesis a lack of focus on astrocytesand most of the tools used to probe and sense astrocytes are derived from those developed to study neurons. ASTROTECH will create and develop the field of Glial Engineering, to provide a consistent range of tools to record, study, and manipulate astrocytes in the healthy and diseased brain. ASTROTECH will train 15 Early Stage Researchers (ESRs) on research, training and complimentary skills aiming at: engineering biomaterials and nanostructured interfaces to provide in vivo-like in vitro models for controlled & reliable studies of astrocytes in vitro; fabrication and characterization of nanostructured devices for stimulation, recording and biosensing of astrocytes; optogenetics tools, optoelectronic device &photonic methods for precice and cell selective stimulation of astrocytes; computationalapproaches to describe and predict neuron-astrocytes interactions.The training on state-of-the-art biomaterials interfaces, electronic, photonic devices will be combined with in depth knowledge on optogenetics, neuroscience, glial physiology and biology and computational methodsto validate the developed tools in vitro, ex vivo, in silico & in pathological models of glioma, ischemia, epilepsy and depression.The ASTROTECH network combines 11 beneficiaries and 14 partners belonging to 9 European and Non-EU countries Academia, Public Research Centersand industrial labs, that combines interdisciplinary, intersectoral and soft skills knowledges where the private sector is highly representedand covers every step “from benchside to bedside” of the value chain. ASTROTECH Glial Engineeringto provide a more complete understanding of brain health and disorders.

Field of science

  • /engineering and technology/industrial biotechnology/biomaterials

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 784 499,04

Participants (10)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 303 172,56
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
Czechia
EU contribution
€ 234 871,56
Address
Videnska 1083
14220 Praha 4
Activity type
Research Organisations
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 549 604,08
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
BCAM - BASQUE CENTER FOR APPLIED MATHEMATICS
Spain
EU contribution
€ 250 904,88
Address
Al Mazarredo 14
48009 Bilbao
Activity type
Research Organisations
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Portugal
EU contribution
€ 237 720,24
Address
Rua Alfredo Allen 208
4200 135 Porto
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 261 499,68
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 261 499,68
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 250 904,88
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
AVANZARE INNOVACION TECNOLOGICA SL
Spain
EU contribution
€ 250 904,88
Address
Avenida Lentiscares 4 6
26370 Navarrete
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OPTOCEUTICS APS
Denmark
EU contribution
€ 595 044
Address
Diplomvej 381
2800 Kongens Lyngby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)