Disruptive materials, technologies & approaches to unravel the role of Astrocytes in brain function and dysfunction: towards to Glial interfaces

Informations projet

ASTROTECH

N° de convention de subvention: 956325

DOI

10.3030/956325

Projet clôturé

Date de signature de la CE 4 Septembre 2020

Date de début 1 Novembre 2020

Date de fin 30 Avril 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 980 625,48

Contribution de l’UE

€ 3 980 625,48

Coordonné par

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (22)

Dissemination, communication and exploitation Plan

Dissemination communication and exploitation Plan

Report on the common training standards and recruitment plans and policies
Final Dissemination, communication and exploitation Plan
Definition of ASTROTECH Management Guidelines AGM
Fabrication and assessment of glioelectronic device efficacy and efficiency in vivo
Biophysical model of astrocytic bioelectricity
Validated glioelectronic carbon based and hybrid device providing stimulation and recording of astrocytes in vitro
Assessment of gliophotonic device efficacy in vivo and protocols for testing in humans
Validated glioelectronic carbon based and hybrid device providing stimulation and recording of astrocytes ex-vivo
Optoceutic device providing stimulation of astrocytes function in vitro and ex vivo
Assessment of glioelectronic device in epileptic model in vivo and pilot in human
Scalable NGVU model and integration in TVB and clinical technology
Design and implementation of glial-based clamping simulations
Properties (viability, structural and functional) of primary astrocytes and co-cultures models in ASTROTECH scaffold
Chemico-physical features of ASTROTECH materials interface
Report on recruitment; Collection of all PDCP

Report on recruitment Collection of all PDCP

Properties of gliotic astrocytes in ASTROTECH scaffold

Properties (viability, structural and functional) of gliotic astrocytes in ASTROTECH scaffold

Assessment of ASTROTECH in vitro model for the study of glioma
Design and Validation of multi-scale models of volume transmission in the NGVU
Validated glioelectronic AuSiNws device providing stimulation and recording of astrocytes in vitro
Optoelectronic devices providing stimulation of astrocytes function in vitro and ex vivo
Validated optogenetic approaches for stimulation and recording of astrocytes function ex vivo

Websites, patent fillings, videos etc. (1)

ASTROTECH website

Publications

Peer reviewed articles (29)

AQP4-dependent glioma cell features affect the phenotype of surrounding cells via extracellular vesicles

Auteurs: Laura Simone; Francesco Pisani; Elena Binda; Antonio Frigeri; Angelo L. Vescovi; Maria Svelto; Grazia P. Nicchia
Publié dans: Cell and BIOSCIENCE, Numéro 1, 2022, ISSN 2045-3701
Éditeur: Society of Chinese Bioscientists in America
DOI: 10.1186/s13578-022-00888-2

Optimizing Electrospun PVA Fibers with MXene Integration for Biomedical Applications

Auteurs: Nergis Zeynep Renkler, Zaheer Ud Din Babar, Mario Barra, Iriczalli Cruz‐Maya, Roberto De Santis, Rocco di Girolamo, Marcello Marelli, Anna Maria Ferretti, Ayesha Zaheer, Vincenzo Iannotti, Vincenzo Guarino
Publié dans: Macromolecular Materials and Engineering, 2025, ISSN 1438-7492
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/mame.202400433

Electrophysiological In Vitro Study of Long-Range Signal Transmission by Astrocytic Networks

Auteurs: Nataly Hastings, Yi-Lin Yu, Botian Huang, Sagnik Middya, Misaki Inaoka,Nadia A. Erkamp, Roger J. Mason, Alejandro Carnicer-Lombarte, Saifur Rahman, Tuomas P. J. Knowles, Manohar Bance, George G. Malliaras, and Mark R. N. Kotter
Publié dans: Advanced Science, 2023, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202301756

The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain

Auteurs: Roberta Pati, Claudia Palazzo, Onofrio Valente, Pasqua Abbrescia, Raffaella Messina, Nicoletta Concetta Surdo, Konstantinos Lefkimmiatis, Francesco Signorelli, Grazia Paola Nicchia, Antonio Frigeri
Publié dans: Biomolecules, Numéro 12, 2025, Page(s) 633, ISSN 2218-273X
Éditeur: MDPI AG
DOI: 10.3390/biom12050633

Optimization of Polyvinyl Alcohol-Based Electrospun Fibers with Bioactive or Electroconductive Phases for Tissue-Engineered Scaffolds

Auteurs: Zeynep Renkler, Iriczalli Cruz Maya, Vincenzo Guarino
Publié dans: Fibers, 2023, ISSN 2079-6439
Éditeur: MDPI
DOI: 10.3390/fib11100085

Micro- and Nanostructured Fibrous Composites via Electro-Fluid Dynamics: Design and Applications for Brain

Auteurs: Nergis Zeynep Renkler, Stefania Scialla, Teresa Russo, Ugo D’Amora, Iriczalli Cruz-Maya, Roberto De Santis, Vincenzo Guarino
Publié dans: Pharmaceutics, 2024, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16010134

Aquaporin-4 and transient receptor potential vanilloid 4 balance in early postnatal neurodevelopment

Auteurs: Antonio Cibelli, Maria Grazia Mola, Emanuela Saracino, Barbara Barile, Pasqua Abbrescia, Guido Mogni, David C. Spray, Eliana Scemes, Andrea Rossi, Diletta Spennato, Maria Svelto, Antonio Frigeri, Valentina Benfenati, Grazia paola Nicchia
Publié dans: GLIA, 2024, ISSN 0894-1491
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/glia.24512

From phenomenological to biophysical models of seizures

Auteurs: Damien Depannemaecker, Aitakin Ezzati, Huifang E. Wang, Viktor Jirsa, Christophe Bernard
Publié dans: Neurobiology of Disease, Numéro 182, 2024, Page(s) 106131, ISSN 0969-9961
Éditeur: Academic Press
DOI: 10.1016/j.nbd.2023.106131

A Mean Field to Capture Asynchronous Irregular Dynamics of Conductance-Based Networks of Adaptive Quadratic Integrate-and-Fire Neuron Models

Auteurs: Christoffer G. Alexandersen, Chloé Duprat, Aitakin Ezzati, Pierre Houzelstein, Ambre Ledoux, Yuhong Liu, Sandra Saghir, Alain Destexhe, Federico Tesler, Damien Depannemaecker
Publié dans: Neural Computation, Numéro 36, 2024, Page(s) 1433-1448, ISSN 0899-7667
Éditeur: MIT Press
DOI: 10.1162/neco_a_01670

Graphene glial-interfaces: challenges and perspectives. Nanoscale.

Auteurs: Fabbri R , Saracino E , Treossi E , Zamboni R , Palermo V , Benfenati V .
Publié dans: Nanoscale, 2021, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0nr07824g

Revealing Low Amplitude Signals of Neuroendocrine Cells through Disordered Silicon Nanowires-Based Microelectrode Array

Auteurs: Francesco Maita, Luca Maiolo, Ivano Lucarini, Josè Ignacio Del Rio De Vicente, Antonio Sciortino, Mario Ledda, Valentina Mussi, Antonella Lisi, Annalisa Convertino
Publié dans: Advanced Science, 2023, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202301925

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Auteurs: Iriczalli Cruz-Maya, Carmine Schiavone, Rosalia Ferraro, Nergis Zeynep Renkler, Sergio Caserta, Vincenzo Guarino
Publié dans: Pharmaceutics, 2024, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16020193

Glial Interfaces: Advanced Materials and Devices to Uncover the Role of Astroglial Cells in Brain Function and Dysfunction

Auteurs: Maiolo L, Guarino V, Saracino E, Convertino A, Melucci M, Muccini M, Ambrosio L, Zamboni R, Benfenati V.
Publié dans: Advanced Healthcare Materials, 2021, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001268

An Easy-to-Handle Route for Bicomponent Porous Tubes Fabrication as Nerve Guide Conduits

Auteurs: Teresa Russo, Stefania Scialla, Marietta D’Albore, Iriczalli Cruz-Maya, Roberto De Santis, Vincenzo Guarino
Publié dans: Polymers, Numéro 16, 2024, Page(s) 2893, ISSN 2073-4360
Éditeur: MDPI AG
DOI: 10.3390/polym16202893

Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity

Auteurs: Theresia Arbring Sjöström, Anton I. Ivanov, Nariman Kiani, Iwona Bernacka‐Wojcik, Jennifer Samuelsson, Helena Saarela Unemo, Dionysios Xydias, Lida‐Evmorfia Vagiaki, Sotiris Psilodimitrakopoulos, Ioannis Konidakis, Kyriaki Sidiropoulou, Emmanuel Stratakis, Magnus Berggren, Christophe Bernard, Daniel T. Simon
Publié dans: Small, Numéro 21, 2025, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202410906

The Functional Interaction of KATP and BK Channels with Aquaporin-4 in the U87 Glioblastoma Cell

Auteurs: Fatima Maqoud, Laura Simone, Domenico Tricarico, Giulia Maria Camerino, Marina Antonacci, Grazia Paola Nicchia
Publié dans: Biomedicines, Numéro 12, 2025, Page(s) 1891, ISSN 2227-9059
Éditeur: MDPI AG
DOI: 10.3390/biomedicines12081891

Cell Volume Regulation Mechanisms in Differentiated Astrocytes.

Auteurs: Mola MG, Saracino E, Formaggio F, Amerotti AG, Barile B, Posati T, Cibelli A, Frigeri A, Palazzo C, Zamboni R, Caprini M, Nicchia GP, Benfenati V.
Publié dans: Cell Biochemistry and Physiology, 2022, ISSN 1015-8987
Éditeur: S. Karger AG
DOI: 10.33594/000000469

Study on the effect of 40 Hz non-invasive light therapy system. A protocol for a randomized, double-blinded, placebo-controlled clinical trial

Auteurs: Mikkel Pejstrup Agger, Maibritt Horning, Marcus Schultz Carstensen, Else Rubæk Danielsen, Anders Olhues Baandrup, Mai Nguyen, Peter Høgh , Kamilla Miskowiak, Paul Michael Petersen , Kristoffer Hougaard Madsen, Troels Wesenberg Kjær
Publié dans: Frontiers in ageing neuroscience, 2023, ISSN 1663-4365
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnagi.2023.1250626

Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes

Auteurs: Roberta Fabbri, Alessandra Scidà, Emanuela Saracino, Giorgia Conte, Alessandro Kovtun, Andrea Candini, Denisa Kirdajova, Diletta Spennato, Valeria Marchetti, Chiara Lazzarini, Aikaterini Konstantoulaki, Paolo Dambruoso, Marco Caprini, Michele Muccini, Mauro Ursino, Miroslava Anderova, Emanuele Treossi, Roberto Zamboni, Vincenzo Palermo, Valentina Benfenati
Publié dans: Nature Nanotechnology, Numéro 19, 2024, Page(s) 1344-1353, ISSN 1748-3387
Éditeur: Nature Publishing Group
DOI: 10.1038/s41565-024-01711-4

Simple dynamic cell culture system reduces recording noise in microelectrode array recordings

Auteurs: Darius Hoven, Misaki Inaoka, Reece McCoy, Aimee Withers, Róisín M. Owens, George G. Malliaras
Publié dans: MRS Communications, Numéro 14, 2024, Page(s) 261-266, ISSN 2159-6867
Éditeur: Springer Science and Business Media LLC
DOI: 10.1557/s43579-024-00554-3

Green Routes for Bio-Fabrication in Biomedical and Pharmaceutical Applications

Auteurs: Carla Serri, Iriczalli Cruz-Maya, Irene Bonadies, Giovanna Rassu, Paolo Giunchedi, Elisabetta Gavini, Vincenzo Guarino
Publié dans: Pharmaceutics, Numéro 15, 2023, Page(s) 1744, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15061744

Editorial: Women in neuroengineering and neurotechnologies

Auteurs: Michela Chiappalone, Alessandra Pedrocchi, Suha Abuarqub, Chiara Bartolozzi, Valentina Benfenati, Silvia Giordani, Elvira Pirondini, Marianna Semprini
Publié dans: Frontiers in Neuroscience, Numéro 19, 2025, ISSN 1662-453X
Éditeur: Frontiers Media SA
DOI: 10.3389/fnins.2025.1542839

Electroconductive and injectable hydrogels based on gelatin and PEDOT:PSS for a minimally invasive approach in nervous tissue regeneration

Auteurs: Furlani F, Montanari M, Sangiorgi N, Saracino E, Campodoni E, Sanson A, Benfenati V, Tampieri A, Panseri S, Sandri M.
Publié dans: Biomaterials Science, 2022, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2bm00116k

Electro Fluid Dynamics: A Route to Design Polymers and Composites for Biomedical and Bio-Sustainable Applications

Auteurs: Renkler, NZ (Renkler, Nergis Zeynep) ; Cruz-Maya, I (Cruz-Maya, Iriczalli) ; Bonadies, I (Bonadies, Irene) [1] ; Guarino, V
Publié dans: Polymers, 2022, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym14194249

ALS-like pathology diminishes swelling of spinal astrocytes in the SOD1 animal model

Auteurs: Tereza Filipi, Jana Tureckova, Ondrej Vanatko, Martina Chmelova, Monika Kubiskova, Natalia Sirotova, Stanislava Matejkova, Lydia Vargova, Miroslava Anderova
Publié dans: Frontiers in Cellular Neuroscience, Numéro 18, 2024, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1472374

Innovative solutions for disease management

Auteurs: Dafni Carmina, Valentina Benfenati, Claudia Simonelli, Alessia Rotolo, Paola Cardano, Nicoletta Grovale, Lorenza Mangoni di S. Stefano, Tiziana de Santo, Roberto Zamboni, Vincenzo Palermo, Michele Muccini, Francesco De Seta
Publié dans: Bioelectronic Medicine, Numéro 9, 2023, ISSN 2332-8886
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s42234-023-00131-4

AQP4-independent TRPV4 modulation of plasma membrane water permeability

Auteurs: Barbara Barile, Maria Grazia Mola, Francesco Formaggio,Emanuela Saracino, Antonio Cibelli, Concetta Domenica Gargano, Guido Mogni, Antonio Frigeri,Marco Caprini, Valentina Benfenati and Grazia Paola Nicchia
Publié dans: Frontiers in cellular neuroscience, 2023, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1247761

Safety, Feasibility, and Potential Clinical Efficacy of 40 Hz Invisible Spectral Flicker versus Placebo in Patients with Mild-to-Moderate Alzheimer’s Disease: A Randomized, Placebo-Controlled, Double-Blinded, Pilot Study

Auteurs: Agger, Mikkel Pejstrup; Danielsen, Else Rubæk; Carstensen, Marcus Schultz; Nguyen, N. Mai; Horning, Maibritt; Henney, Mark Alexander; Jensen, Christopher Boe Ravn; Baandrup, Anders Ohlhues; Kjær, Troels Wesenberg; Madsen, Kristoffer Hougaard; Miskowiak, Kamilla; Petersen, Paul Michael; Høgh, Peter
Publié dans: Journal of Alzheimer's Disease, Numéro 2, 2023, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/jad-221238

Astrocytic TRPV4 Channels and Their Role in Brain Ischemia

Auteurs: Jana Tureckova, Zuzana Hermanova, Valeria Marchetti, Miroslava Anderova
Publié dans: International journal of molecular sciences, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24087101

Book chapters (1)

Ionotropic cross-linked polymeric beads for drug delivery and in vitro applications

Auteurs: Iriczalli Cruz-Maya, Nergis Zeynep Renkler, Luigi Ambrosio, Vincenzo Guarino
Publié dans: Ionotropic Cross-Linking of Biopolymers, 2024, Page(s) 387-416
Éditeur: Elsevier
DOI: 10.1016/b978-0-323-96116-5.00020-x

Non-peer reviewed articles (1)

Protocol to downregulate GABAergic-astrocyte signaling via astrocyte-selective ablation of GABAB receptor in adult mice

Auteurs: Sara Mederos, Andrea Sánchez-Ruiz, Gertrudis Perea
Publié dans: STAR Protocols, Numéro 3, 2024, Page(s) 101667, ISSN 2666-1667
Éditeur: Elsevier BV
DOI: 10.1016/j.xpro.2022.101667

Conference proceedings (1)

Development of ZnO NRs-rGO Low-Impedance Electrodes for Astrocyte Cell Signal Recording

Auteurs: José Ignacio Del Río De Vicente, Ivano Lucarini, Francesco Maita, Davide Salvò, Valeria Marchetti, Miroslava Anderova, Julio Gómez, Luca Maiolo
Publié dans: 2023 IEEE SENSORS, 2024, Page(s) 1-4
Éditeur: IEEE
DOI: 10.1109/sensors56945.2023.10325202