Disruptive materials, technologies & approaches to unravel the role of Astrocytes in brain function and dysfunction: towards to Glial interfaces

Informazioni relative al progetto

ASTROTECH

ID dell’accordo di sovvenzione: 956325

DOI

10.3030/956325

Progetto chiuso

Data della firma CE 4 Settembre 2020

Data di avvio 1 Novembre 2020

Data di completamento 30 Aprile 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 980 625,48

Contributo UE

€ 3 980 625,48

Coordinato da

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (22)

Dissemination, communication and exploitation Plan

Dissemination communication and exploitation Plan

Report on the common training standards and recruitment plans and policies
Final Dissemination, communication and exploitation Plan
Definition of ASTROTECH Management Guidelines AGM
Fabrication and assessment of glioelectronic device efficacy and efficiency in vivo
Biophysical model of astrocytic bioelectricity
Validated glioelectronic carbon based and hybrid device providing stimulation and recording of astrocytes in vitro
Assessment of gliophotonic device efficacy in vivo and protocols for testing in humans
Validated glioelectronic carbon based and hybrid device providing stimulation and recording of astrocytes ex-vivo
Optoceutic device providing stimulation of astrocytes function in vitro and ex vivo
Assessment of glioelectronic device in epileptic model in vivo and pilot in human
Scalable NGVU model and integration in TVB and clinical technology
Design and implementation of glial-based clamping simulations
Properties (viability, structural and functional) of primary astrocytes and co-cultures models in ASTROTECH scaffold
Chemico-physical features of ASTROTECH materials interface
Report on recruitment; Collection of all PDCP

Report on recruitment Collection of all PDCP

Properties of gliotic astrocytes in ASTROTECH scaffold

Properties (viability, structural and functional) of gliotic astrocytes in ASTROTECH scaffold

Assessment of ASTROTECH in vitro model for the study of glioma
Design and Validation of multi-scale models of volume transmission in the NGVU
Validated glioelectronic AuSiNws device providing stimulation and recording of astrocytes in vitro
Optoelectronic devices providing stimulation of astrocytes function in vitro and ex vivo
Validated optogenetic approaches for stimulation and recording of astrocytes function ex vivo

Websites, patent fillings, videos etc. (1)

ASTROTECH website

Pubblicazioni

Peer reviewed articles (29)

AQP4-dependent glioma cell features affect the phenotype of surrounding cells via extracellular vesicles

Autori: Laura Simone; Francesco Pisani; Elena Binda; Antonio Frigeri; Angelo L. Vescovi; Maria Svelto; Grazia P. Nicchia
Pubblicato in: Cell and BIOSCIENCE, Numero 1, 2022, ISSN 2045-3701
Editore: Society of Chinese Bioscientists in America
DOI: 10.1186/s13578-022-00888-2

Optimizing Electrospun PVA Fibers with MXene Integration for Biomedical Applications

Autori: Nergis Zeynep Renkler, Zaheer Ud Din Babar, Mario Barra, Iriczalli Cruz‐Maya, Roberto De Santis, Rocco di Girolamo, Marcello Marelli, Anna Maria Ferretti, Ayesha Zaheer, Vincenzo Iannotti, Vincenzo Guarino
Pubblicato in: Macromolecular Materials and Engineering, 2025, ISSN 1438-7492
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mame.202400433

Electrophysiological In Vitro Study of Long-Range Signal Transmission by Astrocytic Networks

Autori: Nataly Hastings, Yi-Lin Yu, Botian Huang, Sagnik Middya, Misaki Inaoka,Nadia A. Erkamp, Roger J. Mason, Alejandro Carnicer-Lombarte, Saifur Rahman, Tuomas P. J. Knowles, Manohar Bance, George G. Malliaras, and Mark R. N. Kotter
Pubblicato in: Advanced Science, 2023, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202301756

The Readthrough Isoform AQP4ex Is Constitutively Phosphorylated in the Perivascular Astrocyte Endfeet of Human Brain

Autori: Roberta Pati, Claudia Palazzo, Onofrio Valente, Pasqua Abbrescia, Raffaella Messina, Nicoletta Concetta Surdo, Konstantinos Lefkimmiatis, Francesco Signorelli, Grazia Paola Nicchia, Antonio Frigeri
Pubblicato in: Biomolecules, Numero 12, 2025, Pagina/e 633, ISSN 2218-273X
Editore: MDPI AG
DOI: 10.3390/biom12050633

Optimization of Polyvinyl Alcohol-Based Electrospun Fibers with Bioactive or Electroconductive Phases for Tissue-Engineered Scaffolds

Autori: Zeynep Renkler, Iriczalli Cruz Maya, Vincenzo Guarino
Pubblicato in: Fibers, 2023, ISSN 2079-6439
Editore: MDPI
DOI: 10.3390/fib11100085

Micro- and Nanostructured Fibrous Composites via Electro-Fluid Dynamics: Design and Applications for Brain

Autori: Nergis Zeynep Renkler, Stefania Scialla, Teresa Russo, Ugo D’Amora, Iriczalli Cruz-Maya, Roberto De Santis, Vincenzo Guarino
Pubblicato in: Pharmaceutics, 2024, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16010134

Aquaporin-4 and transient receptor potential vanilloid 4 balance in early postnatal neurodevelopment

Autori: Antonio Cibelli, Maria Grazia Mola, Emanuela Saracino, Barbara Barile, Pasqua Abbrescia, Guido Mogni, David C. Spray, Eliana Scemes, Andrea Rossi, Diletta Spennato, Maria Svelto, Antonio Frigeri, Valentina Benfenati, Grazia paola Nicchia
Pubblicato in: GLIA, 2024, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.24512

From phenomenological to biophysical models of seizures

Autori: Damien Depannemaecker, Aitakin Ezzati, Huifang E. Wang, Viktor Jirsa, Christophe Bernard
Pubblicato in: Neurobiology of Disease, Numero 182, 2024, Pagina/e 106131, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2023.106131

A Mean Field to Capture Asynchronous Irregular Dynamics of Conductance-Based Networks of Adaptive Quadratic Integrate-and-Fire Neuron Models

Autori: Christoffer G. Alexandersen, Chloé Duprat, Aitakin Ezzati, Pierre Houzelstein, Ambre Ledoux, Yuhong Liu, Sandra Saghir, Alain Destexhe, Federico Tesler, Damien Depannemaecker
Pubblicato in: Neural Computation, Numero 36, 2024, Pagina/e 1433-1448, ISSN 0899-7667
Editore: MIT Press
DOI: 10.1162/neco_a_01670

Graphene glial-interfaces: challenges and perspectives. Nanoscale.

Autori: Fabbri R , Saracino E , Treossi E , Zamboni R , Palermo V , Benfenati V .
Pubblicato in: Nanoscale, 2021, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/d0nr07824g

Revealing Low Amplitude Signals of Neuroendocrine Cells through Disordered Silicon Nanowires-Based Microelectrode Array

Autori: Francesco Maita, Luca Maiolo, Ivano Lucarini, Josè Ignacio Del Rio De Vicente, Antonio Sciortino, Mario Ledda, Valentina Mussi, Antonella Lisi, Annalisa Convertino
Pubblicato in: Advanced Science, 2023, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202301925

Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Autori: Iriczalli Cruz-Maya, Carmine Schiavone, Rosalia Ferraro, Nergis Zeynep Renkler, Sergio Caserta, Vincenzo Guarino
Pubblicato in: Pharmaceutics, 2024, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16020193

Glial Interfaces: Advanced Materials and Devices to Uncover the Role of Astroglial Cells in Brain Function and Dysfunction

Autori: Maiolo L, Guarino V, Saracino E, Convertino A, Melucci M, Muccini M, Ambrosio L, Zamboni R, Benfenati V.
Pubblicato in: Advanced Healthcare Materials, 2021, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001268

An Easy-to-Handle Route for Bicomponent Porous Tubes Fabrication as Nerve Guide Conduits

Autori: Teresa Russo, Stefania Scialla, Marietta D’Albore, Iriczalli Cruz-Maya, Roberto De Santis, Vincenzo Guarino
Pubblicato in: Polymers, Numero 16, 2024, Pagina/e 2893, ISSN 2073-4360
Editore: MDPI AG
DOI: 10.3390/polym16202893

Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity

Autori: Theresia Arbring Sjöström, Anton I. Ivanov, Nariman Kiani, Iwona Bernacka‐Wojcik, Jennifer Samuelsson, Helena Saarela Unemo, Dionysios Xydias, Lida‐Evmorfia Vagiaki, Sotiris Psilodimitrakopoulos, Ioannis Konidakis, Kyriaki Sidiropoulou, Emmanuel Stratakis, Magnus Berggren, Christophe Bernard, Daniel T. Simon
Pubblicato in: Small, Numero 21, 2025, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202410906

The Functional Interaction of KATP and BK Channels with Aquaporin-4 in the U87 Glioblastoma Cell

Autori: Fatima Maqoud, Laura Simone, Domenico Tricarico, Giulia Maria Camerino, Marina Antonacci, Grazia Paola Nicchia
Pubblicato in: Biomedicines, Numero 12, 2025, Pagina/e 1891, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/biomedicines12081891

Cell Volume Regulation Mechanisms in Differentiated Astrocytes.

Autori: Mola MG, Saracino E, Formaggio F, Amerotti AG, Barile B, Posati T, Cibelli A, Frigeri A, Palazzo C, Zamboni R, Caprini M, Nicchia GP, Benfenati V.
Pubblicato in: Cell Biochemistry and Physiology, 2022, ISSN 1015-8987
Editore: S. Karger AG
DOI: 10.33594/000000469

Study on the effect of 40 Hz non-invasive light therapy system. A protocol for a randomized, double-blinded, placebo-controlled clinical trial

Autori: Mikkel Pejstrup Agger, Maibritt Horning, Marcus Schultz Carstensen, Else Rubæk Danielsen, Anders Olhues Baandrup, Mai Nguyen, Peter Høgh , Kamilla Miskowiak, Paul Michael Petersen , Kristoffer Hougaard Madsen, Troels Wesenberg Kjær
Pubblicato in: Frontiers in ageing neuroscience, 2023, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2023.1250626

Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes

Autori: Roberta Fabbri, Alessandra Scidà, Emanuela Saracino, Giorgia Conte, Alessandro Kovtun, Andrea Candini, Denisa Kirdajova, Diletta Spennato, Valeria Marchetti, Chiara Lazzarini, Aikaterini Konstantoulaki, Paolo Dambruoso, Marco Caprini, Michele Muccini, Mauro Ursino, Miroslava Anderova, Emanuele Treossi, Roberto Zamboni, Vincenzo Palermo, Valentina Benfenati
Pubblicato in: Nature Nanotechnology, Numero 19, 2024, Pagina/e 1344-1353, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-024-01711-4

Simple dynamic cell culture system reduces recording noise in microelectrode array recordings

Autori: Darius Hoven, Misaki Inaoka, Reece McCoy, Aimee Withers, Róisín M. Owens, George G. Malliaras
Pubblicato in: MRS Communications, Numero 14, 2024, Pagina/e 261-266, ISSN 2159-6867
Editore: Springer Science and Business Media LLC
DOI: 10.1557/s43579-024-00554-3

Green Routes for Bio-Fabrication in Biomedical and Pharmaceutical Applications

Autori: Carla Serri, Iriczalli Cruz-Maya, Irene Bonadies, Giovanna Rassu, Paolo Giunchedi, Elisabetta Gavini, Vincenzo Guarino
Pubblicato in: Pharmaceutics, Numero 15, 2023, Pagina/e 1744, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15061744

Editorial: Women in neuroengineering and neurotechnologies

Autori: Michela Chiappalone, Alessandra Pedrocchi, Suha Abuarqub, Chiara Bartolozzi, Valentina Benfenati, Silvia Giordani, Elvira Pirondini, Marianna Semprini
Pubblicato in: Frontiers in Neuroscience, Numero 19, 2025, ISSN 1662-453X
Editore: Frontiers Media SA
DOI: 10.3389/fnins.2025.1542839

Electroconductive and injectable hydrogels based on gelatin and PEDOT:PSS for a minimally invasive approach in nervous tissue regeneration

Autori: Furlani F, Montanari M, Sangiorgi N, Saracino E, Campodoni E, Sanson A, Benfenati V, Tampieri A, Panseri S, Sandri M.
Pubblicato in: Biomaterials Science, 2022, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d2bm00116k

Electro Fluid Dynamics: A Route to Design Polymers and Composites for Biomedical and Bio-Sustainable Applications

Autori: Renkler, NZ (Renkler, Nergis Zeynep) ; Cruz-Maya, I (Cruz-Maya, Iriczalli) ; Bonadies, I (Bonadies, Irene) [1] ; Guarino, V
Pubblicato in: Polymers, 2022, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym14194249

ALS-like pathology diminishes swelling of spinal astrocytes in the SOD1 animal model

Autori: Tereza Filipi, Jana Tureckova, Ondrej Vanatko, Martina Chmelova, Monika Kubiskova, Natalia Sirotova, Stanislava Matejkova, Lydia Vargova, Miroslava Anderova
Pubblicato in: Frontiers in Cellular Neuroscience, Numero 18, 2024, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2024.1472374

Innovative solutions for disease management

Autori: Dafni Carmina, Valentina Benfenati, Claudia Simonelli, Alessia Rotolo, Paola Cardano, Nicoletta Grovale, Lorenza Mangoni di S. Stefano, Tiziana de Santo, Roberto Zamboni, Vincenzo Palermo, Michele Muccini, Francesco De Seta
Pubblicato in: Bioelectronic Medicine, Numero 9, 2023, ISSN 2332-8886
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s42234-023-00131-4

AQP4-independent TRPV4 modulation of plasma membrane water permeability

Autori: Barbara Barile, Maria Grazia Mola, Francesco Formaggio,Emanuela Saracino, Antonio Cibelli, Concetta Domenica Gargano, Guido Mogni, Antonio Frigeri,Marco Caprini, Valentina Benfenati and Grazia Paola Nicchia
Pubblicato in: Frontiers in cellular neuroscience, 2023, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1247761

Safety, Feasibility, and Potential Clinical Efficacy of 40 Hz Invisible Spectral Flicker versus Placebo in Patients with Mild-to-Moderate Alzheimer’s Disease: A Randomized, Placebo-Controlled, Double-Blinded, Pilot Study

Autori: Agger, Mikkel Pejstrup; Danielsen, Else Rubæk; Carstensen, Marcus Schultz; Nguyen, N. Mai; Horning, Maibritt; Henney, Mark Alexander; Jensen, Christopher Boe Ravn; Baandrup, Anders Ohlhues; Kjær, Troels Wesenberg; Madsen, Kristoffer Hougaard; Miskowiak, Kamilla; Petersen, Paul Michael; Høgh, Peter
Pubblicato in: Journal of Alzheimer's Disease, Numero 2, 2023, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/jad-221238

Astrocytic TRPV4 Channels and Their Role in Brain Ischemia

Autori: Jana Tureckova, Zuzana Hermanova, Valeria Marchetti, Miroslava Anderova
Pubblicato in: International journal of molecular sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24087101

Book chapters (1)

Ionotropic cross-linked polymeric beads for drug delivery and in vitro applications

Autori: Iriczalli Cruz-Maya, Nergis Zeynep Renkler, Luigi Ambrosio, Vincenzo Guarino
Pubblicato in: Ionotropic Cross-Linking of Biopolymers, 2024, Pagina/e 387-416
Editore: Elsevier
DOI: 10.1016/b978-0-323-96116-5.00020-x

Non-peer reviewed articles (1)

Protocol to downregulate GABAergic-astrocyte signaling via astrocyte-selective ablation of GABAB receptor in adult mice

Autori: Sara Mederos, Andrea Sánchez-Ruiz, Gertrudis Perea
Pubblicato in: STAR Protocols, Numero 3, 2024, Pagina/e 101667, ISSN 2666-1667
Editore: Elsevier BV
DOI: 10.1016/j.xpro.2022.101667

Conference proceedings (1)

Development of ZnO NRs-rGO Low-Impedance Electrodes for Astrocyte Cell Signal Recording

Autori: José Ignacio Del Río De Vicente, Ivano Lucarini, Francesco Maita, Davide Salvò, Valeria Marchetti, Miroslava Anderova, Julio Gómez, Luca Maiolo
Pubblicato in: 2023 IEEE SENSORS, 2024, Pagina/e 1-4
Editore: IEEE
DOI: 10.1109/sensors56945.2023.10325202