C-C Bond Formation Using Top Performing Enzymes

Informations projet

CC-TOP

N° de convention de subvention: 956631

DOI

10.3030/956631

Projet clôturé

Date de signature de la CE 20 Août 2020

Date de début 1 Mars 2021

Date de fin 28 Février 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 971 466,72

Contribution de l’UE

€ 3 971 466,72

Coordonné par

TECHNISCHE UNIVERSITAT DARMSTADT
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (3)

Education Program Report

Summary of CC-TOP training activities and designed networking events, as a reference for structuring future multidisciplinary training programs

Award of doctoral degrees

Report on status of PhD awarding processes, expected to be completed for all ESR

Report on the structure-function relationship within the PEP enzyme class

Report or scientific review summarizing knowledge gained on the structure-function relationship within the enzyme class of PEP dependent biocatalysts

Other (4)

Training School 3

Industrial Biotechnology training. Industrial skills training.

Training Schools (first part of the project) and Mid-Term Workshop

Kick-off training. Bioinformatics training. Soft skills training. Enabling technology training. Network fellows meeting. Project counselling.

Final Outreach Conference

Dissemination of project results to scientific community, industry stakeholders and trade organizations

CC-TOP vacancies advertised

To recruit among the best candidates, advertisement will start as soon as a favourable evaluation notification is obtained. Vacancies will be published simultaneously through various media: European and world-wide read journals (e.g. Nature Jobs), the EU portal for jobs advert, the Commission’s own pages for the Marie Skłodowska-Curie Actions, CC-TOP website, beneficiaries’ graduate recruiting procedures, and through the colleague network both in academia and industry.

Websites, patent fillings, videos etc. (1)

CC-TOP website

The CCTOP website will be hosted at the coordinators institution as the platform for general information job applications courses project plans and progress and scientific information access to the data repository publications training material

Publications

Peer reviewed articles (11)

Cross-acyloin condensation of aldehydes catalysed by transketolase variants for the synthesis of aliphatic α-hydroxyketones

Auteurs: Giuseppe Arbia, Camille Gadona, Hubert Casajus, Lionel Nauton, Franck Charmantray, Laurence Hecquet
Publié dans: Green Chemistry, Numéro 26, 2024, Page(s) 7320-7330, ISSN 1463-9262
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4gc01373e

Kinetic characterization of two neuraminic acid synthases and evaluation of their application potential

Auteurs: Mehmet Mervan Çakar, Nevena Milčić, Theofania Andreadaki, Simon Charnock, Wolf-Dieter Fessner, Zvjezdana Findrik Blažević
Publié dans: Applied Microbiology and Biotechnology, Numéro 108, 2024, Page(s) 108:446 Pages 1-18, ISSN 0175-7598
Éditeur: Springer Verlag
DOI: 10.1007/s00253-024-13277-1

Broadening The Substrate Scope of Aldolases Through Metagenomic Enzyme Discovery

Auteurs: Andrea Rizzo, Carmen Aranda, James Galman, Annette Alcasabas, Akash Pandya, Amin Bornadel, Bruna Costa, Helen C. Hailes, John M. Ward, Jack W. E. Jeffries, Beatriz Dominguez
Publié dans: ChemBioChem, Numéro Broadening The Substrate Scope of Aldolases Through Metagenomic Enzyme Discovery, 2024, Page(s) Volume25, Numéro20 October 16, 2024 e202400278, ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400278

Identification of Kibdelomycin and Related Biosynthetic Gene Clusters and Characterization of the C‐Branching of Amycolose

Auteurs: Leonhard Krug, Daniela Bjarnesen, Lucrezia Lanza, Lucia Lindemann, Nico D. Fessner, Michael Müller
Publié dans: Angewandte Chemie International Edition, Numéro October 14, 2024 , Volume63, Numéro42 e202403535, 2024, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202403535

Expanding the Enzymatic Toolbox for Carboligation: Increasing the Diversity of the ‘Split’ Transketolase Sequence Space

Auteurs: Alessia Tonoli, Silvia Anselmi, John M. Ward, Helen C. Hailes, Jack W. E. Jeffries
Publié dans: ChemBioChem, Numéro 26, 2025, Page(s) ChemBioChem 2025, 26, e202401028 (1 of 10), ISSN 1439-4227
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202401028

Enzymatic Upgrading of Biomass-Derived Aldoses to Rare Deoxy Ketoses Catalyzed by Transketolase Variants

Auteurs: Giuseppe Arbia, Muriel Joly, Lionel Nauton, Camilla Leogrande, Kai Tittmann, Franck Charmantray, Laurence Hecquet
Publié dans: ChemSusChem, Numéro Online Version of Record before inclusion in an issue e202401834 Hot Topic: Biocatalysis, 2024, Page(s) e202401834, ISSN 1864-5631
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.2024018342024

Enzyme Reaction Engineering as a Tool to Investigate the Potential Application of Enzyme Reaction Systems

Auteurs: Nevena Milčić, Ivana Ćevid, Mehmet Mervan Çakar, Martina Sudar, Zvjezdana Findrik Blažević
Publié dans: Hungarian Journal of Industry and Chemistry, Numéro Vol. 50 No. 1 (2022):, 2022, Page(s) 45–55, ISSN 2450-5102
Éditeur: University of Pannonia, Faculty of Engineering
DOI: 10.33927/hjic-2022-08

Bacteria-Mediated Intracellular Radical Polymerizations

Auteurs: Eleonora Ornati, Jules Perrard, Tobias A. Hoffmann, Raissa Bonon, Nico Bruns
Publié dans: Journal of the American Chemical Society, Numéro 147, 2025, Page(s) 9496-9504, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.4c17257

Discovery of Plastics-degrading Enzymes

Auteurs: Mehmet Mervan Çakar, Marija Vuković Domanovac, Zvjezdana Findrik Blažević
Publié dans: Kemija u industriji, Numéro Kem. Ind. 72 (7-8) (2023), 2023, Page(s) 473–485, ISSN 1334-9090
Éditeur: Journal of Chemists and Chemical Engineers of Croatia
DOI: 10.15255/kui.2022.076

Synthesis of Deoxysugars from Aliphatic α-Ketoacids and Aldoses Catalyzed by Thermostable Transketolase Variants from Geobacillus stearothermophilus.

Auteurs: Nazim Ocal, Giuseppe Arbia, Aurélie Lagarde, Muriel Joly, Samantha Gittings, Kirsty M. Graham, Franck Charmantray, Laurence Hecquet
Publié dans: Advanced Synthesis & Catalysis, Numéro Volume365, Numéro1 January 10, 2023, 2023, Page(s) 78-87, ISSN 1615-4169
Éditeur: Wiley online Library
DOI: 10.1002/adsc.202201190

Identification and Characterization of Thiamine Diphosphate‐Dependent Lyases with an Unusual CDG Motif

Auteurs: Lucrezia Lanza, Fabian Rabe von Pappenheim, Daniela Bjarnesen, Camilla Leogrande, Alexandra Paul, Leonhard Krug, Kai Tittmann, Michael Müller
Publié dans: Angewandte Chemie, Numéro 136, 2024, Page(s) Angew Chem Int Ed Engl. 2024 Jun 14:e202404045., ISSN 0044-8249
Éditeur: Wiley com
DOI: 10.1002/ange.202404045

Other (1)

Crystal structure of transketolase from Geobacillus stearothermophilus

Auteurs: Leogrande, C., Rabe von Pappenheim, F., Tittmann, K.
Publié dans: RCSB Protein Data Bank, Numéro Online Database, 2023, Page(s) N/A
Éditeur: RCSB Protein Data Bank (RCSB PDB)
DOI: 10.2210/pdb8cip/pdb