C-C Bond Formation Using Top Performing Enzymes

Informazioni relative al progetto

CC-TOP

ID dell’accordo di sovvenzione: 956631

DOI

10.3030/956631

Progetto chiuso

Data della firma CE 20 Agosto 2020

Data di avvio 1 Marzo 2021

Data di completamento 28 Febbraio 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 971 466,72

Contributo UE

€ 3 971 466,72

Coordinato da

TECHNISCHE UNIVERSITAT DARMSTADT
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Education Program Report

Summary of CC-TOP training activities and designed networking events, as a reference for structuring future multidisciplinary training programs

Award of doctoral degrees

Report on status of PhD awarding processes, expected to be completed for all ESR

Report on the structure-function relationship within the PEP enzyme class

Report or scientific review summarizing knowledge gained on the structure-function relationship within the enzyme class of PEP dependent biocatalysts

Other (4)

Training School 3

Industrial Biotechnology training. Industrial skills training.

Training Schools (first part of the project) and Mid-Term Workshop

Kick-off training. Bioinformatics training. Soft skills training. Enabling technology training. Network fellows meeting. Project counselling.

Final Outreach Conference

Dissemination of project results to scientific community, industry stakeholders and trade organizations

CC-TOP vacancies advertised

To recruit among the best candidates, advertisement will start as soon as a favourable evaluation notification is obtained. Vacancies will be published simultaneously through various media: European and world-wide read journals (e.g. Nature Jobs), the EU portal for jobs advert, the Commission’s own pages for the Marie Skłodowska-Curie Actions, CC-TOP website, beneficiaries’ graduate recruiting procedures, and through the colleague network both in academia and industry.

Websites, patent fillings, videos etc. (1)

CC-TOP website

The CCTOP website will be hosted at the coordinators institution as the platform for general information job applications courses project plans and progress and scientific information access to the data repository publications training material

Pubblicazioni

Peer reviewed articles (11)

Cross-acyloin condensation of aldehydes catalysed by transketolase variants for the synthesis of aliphatic α-hydroxyketones

Autori: Giuseppe Arbia, Camille Gadona, Hubert Casajus, Lionel Nauton, Franck Charmantray, Laurence Hecquet
Pubblicato in: Green Chemistry, Numero 26, 2024, Pagina/e 7320-7330, ISSN 1463-9262
Editore: Royal Society of Chemistry
DOI: 10.1039/d4gc01373e

Kinetic characterization of two neuraminic acid synthases and evaluation of their application potential

Autori: Mehmet Mervan Çakar, Nevena Milčić, Theofania Andreadaki, Simon Charnock, Wolf-Dieter Fessner, Zvjezdana Findrik Blažević
Pubblicato in: Applied Microbiology and Biotechnology, Numero 108, 2024, Pagina/e 108:446 Pages 1-18, ISSN 0175-7598
Editore: Springer Verlag
DOI: 10.1007/s00253-024-13277-1

Broadening The Substrate Scope of Aldolases Through Metagenomic Enzyme Discovery

Autori: Andrea Rizzo, Carmen Aranda, James Galman, Annette Alcasabas, Akash Pandya, Amin Bornadel, Bruna Costa, Helen C. Hailes, John M. Ward, Jack W. E. Jeffries, Beatriz Dominguez
Pubblicato in: ChemBioChem, Numero Broadening The Substrate Scope of Aldolases Through Metagenomic Enzyme Discovery, 2024, Pagina/e Volume25, Numero20 October 16, 2024 e202400278, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400278

Identification of Kibdelomycin and Related Biosynthetic Gene Clusters and Characterization of the C‐Branching of Amycolose

Autori: Leonhard Krug, Daniela Bjarnesen, Lucrezia Lanza, Lucia Lindemann, Nico D. Fessner, Michael Müller
Pubblicato in: Angewandte Chemie International Edition, Numero October 14, 2024 , Volume63, Numero42 e202403535, 2024, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202403535

Expanding the Enzymatic Toolbox for Carboligation: Increasing the Diversity of the ‘Split’ Transketolase Sequence Space

Autori: Alessia Tonoli, Silvia Anselmi, John M. Ward, Helen C. Hailes, Jack W. E. Jeffries
Pubblicato in: ChemBioChem, Numero 26, 2025, Pagina/e ChemBioChem 2025, 26, e202401028 (1 of 10), ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202401028

Enzymatic Upgrading of Biomass-Derived Aldoses to Rare Deoxy Ketoses Catalyzed by Transketolase Variants

Autori: Giuseppe Arbia, Muriel Joly, Lionel Nauton, Camilla Leogrande, Kai Tittmann, Franck Charmantray, Laurence Hecquet
Pubblicato in: ChemSusChem, Numero Online Version of Record before inclusion in an issue e202401834 Hot Topic: Biocatalysis, 2024, Pagina/e e202401834, ISSN 1864-5631
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.2024018342024

Enzyme Reaction Engineering as a Tool to Investigate the Potential Application of Enzyme Reaction Systems

Autori: Nevena Milčić, Ivana Ćevid, Mehmet Mervan Çakar, Martina Sudar, Zvjezdana Findrik Blažević
Pubblicato in: Hungarian Journal of Industry and Chemistry, Numero Vol. 50 No. 1 (2022):, 2022, Pagina/e 45–55, ISSN 2450-5102
Editore: University of Pannonia, Faculty of Engineering
DOI: 10.33927/hjic-2022-08

Bacteria-Mediated Intracellular Radical Polymerizations

Autori: Eleonora Ornati, Jules Perrard, Tobias A. Hoffmann, Raissa Bonon, Nico Bruns
Pubblicato in: Journal of the American Chemical Society, Numero 147, 2025, Pagina/e 9496-9504, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c17257

Discovery of Plastics-degrading Enzymes

Autori: Mehmet Mervan Çakar, Marija Vuković Domanovac, Zvjezdana Findrik Blažević
Pubblicato in: Kemija u industriji, Numero Kem. Ind. 72 (7-8) (2023), 2023, Pagina/e 473–485, ISSN 1334-9090
Editore: Journal of Chemists and Chemical Engineers of Croatia
DOI: 10.15255/kui.2022.076

Synthesis of Deoxysugars from Aliphatic α-Ketoacids and Aldoses Catalyzed by Thermostable Transketolase Variants from Geobacillus stearothermophilus.

Autori: Nazim Ocal, Giuseppe Arbia, Aurélie Lagarde, Muriel Joly, Samantha Gittings, Kirsty M. Graham, Franck Charmantray, Laurence Hecquet
Pubblicato in: Advanced Synthesis & Catalysis, Numero Volume365, Numero1 January 10, 2023, 2023, Pagina/e 78-87, ISSN 1615-4169
Editore: Wiley online Library
DOI: 10.1002/adsc.202201190

Identification and Characterization of Thiamine Diphosphate‐Dependent Lyases with an Unusual CDG Motif

Autori: Lucrezia Lanza, Fabian Rabe von Pappenheim, Daniela Bjarnesen, Camilla Leogrande, Alexandra Paul, Leonhard Krug, Kai Tittmann, Michael Müller
Pubblicato in: Angewandte Chemie, Numero 136, 2024, Pagina/e Angew Chem Int Ed Engl. 2024 Jun 14:e202404045., ISSN 0044-8249
Editore: Wiley com
DOI: 10.1002/ange.202404045

Other (1)

Crystal structure of transketolase from Geobacillus stearothermophilus

Autori: Leogrande, C., Rabe von Pappenheim, F., Tittmann, K.
Pubblicato in: RCSB Protein Data Bank, Numero Online Database, 2023, Pagina/e N/A
Editore: RCSB Protein Data Bank (RCSB PDB)
DOI: 10.2210/pdb8cip/pdb