Project description
Using long non-coding RNAs as diagnostic biomarkers
Accumulating evidence underscores various important biological roles for non-coding RNAs (nc-RNAs). RNAs with a length of more than 200 nucleotides, the long non-coding RNAs (lncRNAs), can potentially serve as diagnostic biomarkers as their aberrant expression has been linked to various neurodegenerative and psychiatric diseases, diabetes and cancer. However, current technologies for lncRNA isolation and detection are laborious and hence unsuitable for routine diagnosis. Employing computer modelling for molecular reactions and RNA structure, scientists of the EU-funded LONGSENSE project aim to develop a novel biosensor for lncRNA detection both for research and diagnostic purposes.
Objective
The function of ribonucleic acid (RNA) was long thought to be only an intermediate product in the protein synthesis machinery, but this view changed since the biological significance of the non-coding protein fraction of RNA was discovered. More recently a still evolving class of RNAs with a length above 200 nucleotides, the long non-coding RNAs (lncRNA) came into the spotlight. Up- or downregulation have been associated with human diseases, such as neurodegenerative and psychiatric diseases, cardiac diseases, diabetes as well as cancer, offering the possibility to use lncRNA as biomarker for diagnosis and prognosis. The currently used method for lncRNA detection is complicated and only a reliable method for an experienced researcher with the necessary lab facilities. Detection of lncRNA follows a time-consuming protocol, taking at least 1 day from sample preparation to analysed data. To exploit the full potential of lncRNA as new biomarker for several diseases, the detection method needs to be simplified. This would allow to use lncRNA as biomarker on-spot in private praxis and integrate lncRNA in the routine diagnostic of clinics. LONGSENSE will develop a fast, user-friendly and cost-effective biosensor for lncRNA detection. The use of computer modelling for molecular reactions and RNA structure, will enable us to work efficiently and remain flexible to the rapid development in the scientific field and adapt a product to meet the needs of the market. The aims of the project are to (1) create a multi-level biosensor for the detection of disease relevant lncRNA in well-plate format for high throughput screening to be used in clinical labs or research; (2) design a device to be used on the spot; (3) asses the commercial feasibility of the technology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC-LS - ERC Proof of Concept Lump Sum Pilot
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2020-PoC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
64289 DARMSTADT
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.