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Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models.

Objective

The aim of ‘AMNIOGEL’ is the development of human extracellular matrix (ECM) based materials, as radically innovative,
highly versatile human-derived platforms for 3D cell culture, microtissue development and disease models establishment. In
particular, we will develop 3D disease models that could be used as an enabling tool for personalized drug discovery,
increasing our understanding of the mechanisms behind bone cancer.
The proposed cutting-edge technology enables the culture of human cells in a physiologically relevant microenvironment for
applications in cell culture research, drug screening and development, cancer research, tissue engineering, replacement of
animal testing and therapeutic applications. The potential of this technology to reduce or completely replace use of animals
for biological screenings is expected to have a significant impact in the 3D cell culture market and pharmaceutical industry
by accelerating drug screening and development reducing associated costs. The innovation potential of our products is
based on the fact that contain human biochemical cues (vital for cell function), is a complete xeno-free solution (avoids
contamination) for human cell culture and easy to manipulate. It is worth mentioning that offers the possibility to be
personalised (using the patient’s own ECM) according to the customer needs. Moreover, our culture substrates are easily
processed in multiple geometries and in microarrays amenable to ‘organ-on- a-chip’ systems designed for high-throughput
screening (HTS) applications.

Field of science

  • /medical and health sciences/medical biotechnology/tissue engineering
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

ERC-2020-PoC
See other projects for this call

Funding Scheme

ERC-POC-LS - ERC Proof of Concept Lump Sum Pilot

Host institution

UNIVERSIDADE DE AVEIRO
Address
Campus Universitário De Santiago
3810-193 Aveiro
Portugal
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 150 000

Beneficiaries (1)

UNIVERSIDADE DE AVEIRO
Portugal
EU contribution
€ 150 000
Address
Campus Universitário De Santiago
3810-193 Aveiro
Activity type
Higher or Secondary Education Establishments