Project description
Personalised extracellular matrix for the ex vivo culture of human cells
Many biomedical processes including tissue engineering and drug discovery employ in vitro human cell culture. The EU-funded AMNIOGEL project is working on an innovative product that can be customised to closely resemble the microenvironment of any particular cell type. This is achieved by using the patient’s own extracellular matrix. The AMNIOGEL technology has the capacity to replace animal testing, accelerating drug screening and reducing associated costs. Moreover, it can form any 3D shape and be deposited on microarrays, leading to the production of organ-on-a-chip systems for high-throughput screening applications.
Objective
The aim of ‘AMNIOGEL’ is the development of human extracellular matrix (ECM) based materials, as radically innovative,
highly versatile human-derived platforms for 3D cell culture, microtissue development and disease models establishment. In
particular, we will develop 3D disease models that could be used as an enabling tool for personalized drug discovery,
increasing our understanding of the mechanisms behind bone cancer.
The proposed cutting-edge technology enables the culture of human cells in a physiologically relevant microenvironment for
applications in cell culture research, drug screening and development, cancer research, tissue engineering, replacement of
animal testing and therapeutic applications. The potential of this technology to reduce or completely replace use of animals
for biological screenings is expected to have a significant impact in the 3D cell culture market and pharmaceutical industry
by accelerating drug screening and development reducing associated costs. The innovation potential of our products is
based on the fact that contain human biochemical cues (vital for cell function), is a complete xeno-free solution (avoids
contamination) for human cell culture and easy to manipulate. It is worth mentioning that offers the possibility to be
personalised (using the patient’s own ECM) according to the customer needs. Moreover, our culture substrates are easily
processed in multiple geometries and in microarrays amenable to ‘organ-on- a-chip’ systems designed for high-throughput
screening (HTS) applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine oncology
- natural sciences mathematics pure mathematics geometry
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2020-PoC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3810-193 Aveiro
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.