Optimal use of hospital resources and intervention using suPAR for improving prognosis and care for patients with COVID-19

Información del proyecto

RISCinCOVID

Identificador del acuerdo de subvención: 961844

DOI

10.3030/961844

Proyecto cerrado

Fecha de la firma de la CE 2 Julio 2020

Fecha de inicio 1 Agosto 2020

Fecha de finalización 31 Julio 2022

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Coste total

€ 1 470 057,00

Aportación de la UE

€ 884 990,00

Coordinado por

VIROGATES AS
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

Dissimination of results

ViroGates will use efforts to dissiminate the results obtained by the consortium. This can be through marketing material, video presentations, presentation at conferences, and through SoMe, e.g. Linkedin etc.

Final data reporting

Final data report and publication of study results

Documents, reports (4)

Study approval

Approval for the conduct of the trial by the first study site (M1)

Approval by ethical committee in countries where suPAR is not already routine

Approval by ethical committee and regulatory authorities in countries where suPAR is not already routine

Reporting of results

Statistical analysis of data Writing of manuscripts Publication in peer reviewed journals and presentations at conferences etc

Registration and consent

HISS will finalize the protocol and the informed consent forms; EudraCT registration; drafting of contracts between investigators and hospital/university administration

Data sets, microdata, etc (1)

Establish suPAR measurements

Set-up of suPAR measurements in 14 Intensive Care Units (ICUs) in Greece. Three of these already have suPAR set-up, but 11 need to have the suPARnostic QT or suPARnostic Turbidimetric assay installed

Open Research Data Pilot (1)

First patient enrolled

Enrolment of the first patient

Publicaciones

Peer reviewed articles (3)

Soluble Urokinase Receptor (SuPAR) in COVID-19–Related AKI

Autores: Tariq U. Azam, Husam R. Shadid, Pennelope Blakely, Patrick O’Hayer, Hanna Berlin, Michael Pan, Peiyao Zhao, Lili Zhao, Subramaniam Pennathur, Rodica Pop-Busui, Izzet Altintas, Jens Tingleff, Marius A. Stauning, Ove Andersen, Maria-Evangelia Adami, Nicky Solomonidi, Maria Tsilika, Pinkus Tober-Lau, Eleni Arnaoutoglou, Verena Keitel, Frank Tacke, Athanasios Chalkias, Sven H. Loosen, Evangelos J. G
Publicado en: Journal of the American Society of Nephrology, Edición 31/11, 2020, Página(s) 2725-2735, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2020060829

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Autores: Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Georgios Adamis, Konstantinos Tsiakos, Archontoula Fragkou, Aggeliki Rapti, Christina Damoulari, Massimo Fantoni, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Maria Tsilika, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Evan
Publicado en: Nature Medicine, 2021, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-021-01499-z

An open label trial of anakinra to prevent respiratory failure in COVID-19

Autores: Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, D
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.66125