Project description DEENESFRITPL Engineering a novel class of peptides to develop new antibiotics Antimicrobial resistance is a global issue that affects all countries. A successful response also needs to address diagnostics, vaccines, and alternatives to antibiotics for human and animal health. The ERC-funded ENTRAP project will study the current antibiotic resistance crisis that is notably connected to the massive misuse of antibiotics and the lack of novel and efficient compounds. Specifically, it will target ribosomally synthesised and post-translationally modified peptides (RiPP). The project’s overall aim is to engineer a novel class of RiPPs in order to develop innovative antibiotics. As such, it will seek solutions to challenges related to the synthesis, stability and bioavailability of antibiotics. Show the project objective Hide the project objective Objective Antibiotic resistant bacteria are rapidly emerging worldwide. This antibiotic resistance crisis is notably connected to the massive misuse of antibiotics and the lack of novel and efficient compounds. With countless structures and properties, natural products including ribosomally synthesized and post-translationally modified peptides (RiPP) are a promising source of antibiotics . However, their development as effective antibiotics faces many challenges related notably to their synthesis, stability and bioavailability. In the frame of this project, we aim to engineer a novel class of RiPPs in order to develop innovative antibiotics. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords Natural product antibiotic peptide multi-resistant bacteria Staphylococcus Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2020-POC - Call for proposals for ERC Proof of Concept Grant Call for proposal ERC-2020-PoC See other projects for this call Funding Scheme ERC-POC - Proof of Concept Grant Coordinator INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Net EU contribution € 150 000,00 Address 147 rue de l'universite 75007 Paris France See on map Region Ile-de-France Ile-de-France Paris Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Net EU contribution € 150 000,00 Address 147 rue de l'universite 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
