Project description
Knowing with certainty what goes in enhances accuracy regarding what comes out
Serial crystallography is a powerful emerging method for studying the structure of macromolecules using X-ray free-electron lasers and synchrotron radiation facilities. It has recently enabled the structural description of challenging targets, such as membrane proteins, and supports the study of molecular machines 'working' at room temperature in natural conditions. As with any emerging method, standardisation is now required. The EU-funded Serial-X project is planning to deliver simple and inexpensive devices for standardised sample delivery in serial crystallography studies. Being certain of what goes in will make us more certain that our interpretation of what comes out is correct, spurring innovation in basic research, pharmaceutical development and more.
Objective
Serial-X aims to expand of the use of serial crystallography across the academic and industrial life-science community by introducing low cost, flexible and easy to use solutions to the most common problems that occur in serial crystallography experiments today. Serial crystallography is a developing method of macromolecular X-ray crystallography that allows diffraction data to be collected at room temperature from a continuous stream of microcrystals. “ProtonPump”, the ERC Advanced Grant awarded to Richard Neutze, applies time-resolved serial crystallography to observe structural changes that occur during the reduction of molecular oxygen to water by cytochrome c oxidase. This PoC builds directly from technical solutions developed to achieve the scientific goals of “ProtonPump”. Serial crystallography was first developed at an X-ray free electron laser but is increasingly being used at synchrotron radiation facilities. Synchrotrons can potentially support up to two orders of magnitude more serial crystallography users than X-ray free electron lasers. Synchrotron based serial crystallography experiments may also become a mainstream method in structure-based-drug-design. But these possibilities will not be realized if the current lack of standardization in sample delivery continues, which is currently prohibitively expensive and requires a high level of technical support to operate. Serial-X will solve this problem by developing and bringing to market standardized, low-cost, flexible and easy-to-use solutions for sample delivery in serial crystallography studies at synchrotron radiation sources. Serial-X will thereby remove the greatest obstacle currently preventing scientists from using serial crystallography for their own research or for structure based drug-design within a pharmaceutical drug discovery context. A spin off company will be formed to manufacture and distribute the technologies developed within this Proof of Concept Grant.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences physical sciences optics laser physics
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC-LS - ERC Proof of Concept Lump Sum Pilot
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2020-PoC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
405 30 Goeteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.