AN IN VIVO BIOENGINEERED CHIP AS A SMART INTRAVITAL MULTIPHOTON IMAGING WINDOW FOR NEW VALIDATION PROTOCOLS OF BIOMATERIALS

Project Information

IN2SIGHT

Grant agreement ID: 964481

DOI 10.3030/964481

EC signature date 21 December 2020

Start date 1 March 2021

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 438 959,00

EU contribution € 3 438 959,00

Coordinated by

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

Deliverables

Documents, reports (11)

Report on the design of IN2SIGHT, atlas and microlenses

Report on the design of IN2SIGHT atlas and lenses

Protocols for chip implantation and in vivo imaging
Report on the 2PP structuring of the IN2SIGHT
Regulatory Action Plan
Hybrid Nanolithography-2PP fabrication

Hybrid Nanolithography2PP fabrication

Report of immune reaction to INSIGHT
Simulation requirements & design report

Simulation requirements design report

Risk assessment report - M24

Risk assessment report

Risk assessment report - M12

Risk assessment report

Immunological and device modelling report
DMP report

Publications

Peer reviewed articles (7)

A Miniaturized Imaging Window to Quantify Intravital Tissue Regeneration within a 3D Microscaffold in Longitudinal Studies

Author(s): Claudio Conci, Emanuela Jacchetti, Laura Sironi, Lorenzo Gentili, Giulio Cerullo, Roberto Osellame, Giuseppe Chirico, Manuela Teresa Raimondi
Published in: Advanced Optical Materials, Issue 2101103, 2022, Page(s) 1-12, ISSN 2195-1071
Publisher: Wiley online
DOI: 10.1002/adom.202101103

Proteinaceous microstructure in a capillary: a study of non-linear bending dynamics

Author(s): Marini, M., Zeynali, A., Collini, M., Bouzin M, Sironi L., D'Alfonso L., Mantegazza F., Cassina, V., Chirico, G.
Published in: Lab on a chip, Issue 22, 2022, Page(s) 4917-4932, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2lc00697a

Development of an Oriented Co-Culture System Using 3D Scaffolds Fabricated via Non-Linear Lithography.

Author(s): Kordas, A., Manganas, P., Selimis, A., Barmparis, G. D., Farsari, M., & Ranella, A.
Published in: Materials, 2022, Page(s) 15(12), ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma15124349

Multiphoton laser fabrication of hybrid photo-activable biomaterials

Author(s): Margaux Bouzin; Amirbahador Zeynali; Mario Marini; Laura Sironi; Riccardo Scodellaro; Laura D'Alfonso; Maddalena Collini; Giuseppe Chirico
Published in: Sensors (Basel, Switzerland), Issue 1, 2021, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21175891

Microlenses Fabricated by Two-Photon Laser Polymerization for Cell Imaging with Non-Linear Excitation Microscopy.

Author(s): Marini, M., Nardini, A., Vázquez, R. M., Conci, C., Bouzin, M., Collini, M., Osellame, R., Cerullo, G., Kariman, B. S., Farsari, M., Kabouraki, E., Raimondi, M. T., & Chirico, G.
Published in: Adv. Funct. Mater., 2023, Page(s) 2213926, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202213926

High-resolution lightweight and multifunctional 3D printed scaffolds for cell studies.

Author(s): Flamourakis, G., Kordas, A., Papageorgiou, M., Pateraki, V., Farsari, M., & Ranella, A.
Published in: Results in Materials, 2023, ISSN 2590-048X
Publisher: Elsevier
DOI: 10.1016/j.rinma.2023.100393

Two-Photon Polymerization Lithography for Optics and Photonics: Fundamentals, Materials, Technologies, and Applications

Author(s): Wang, H., Zhang, W., Ladika, D., Yu, H., Gailevičius, D., Wang, H., Pan, C. F., Nair, P. N. S., Ke, Y., Mori, T., Chan, J. Y. E., Ruan, Q., Farsari, M., Malinauskas, M., Juodkazis, S., Gu, M., & Yang, J. K. W.
Published in: Advanced Functional Materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214211