AN IN VIVO BIOENGINEERED CHIP AS A SMART INTRAVITAL MULTIPHOTON IMAGING WINDOW FOR NEW VALIDATION PROTOCOLS OF BIOMATERIALS

Informacje na temat projektu

IN2SIGHT

Identyfikator umowy o grant: 964481

DOI

10.3030/964481

Projekt został zamknięty

Data podpisania przez KE 21 Grudnia 2020

Data rozpoczęcia 1 Marca 2021

Data zakończenia 31 Sierpnia 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 3 438 959,00

Wkład UE

€ 3 438 959,00

Koordynowany przez

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (11)

Report on the design of IN2SIGHT, atlas and microlenses

Report on the design of IN2SIGHT atlas and lenses

Protocols for chip implantation and in vivo imaging
Report on the 2PP structuring of the IN2SIGHT
Regulatory Action Plan
Hybrid Nanolithography-2PP fabrication

Hybrid Nanolithography2PP fabrication

Report of immune reaction to INSIGHT
Simulation requirements & design report

Simulation requirements design report

Risk assessment report - M24

Risk assessment report

Risk assessment report - M12

Risk assessment report

Immunological and device modelling report
DMP report

Publikacje

Peer reviewed articles (21)

CollagenFitJ, a FIJI plugin for the quantification of collagen in polarization-resolved second harmonic generation image sets

Autorzy: Radu Hristu, Farzad Fereidouni, Stefan G. Stanciu, Lucian G. Eftimie, Oana C. Voinea, Danielis Rutkauskas, Laura Sironi, Giuseppe Chirico, Denis E. Tranca, Remus R. Glogojeanu, Alberto Diaspro, George A. Stanciu
Opublikowane w: Advanced Photonics Nexus, Numer 4, 2025, Strona(/y) Vol. 4, Numer 3, 037001, ISSN 2791-1519
Wydawca: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.apn.4.3.037001

Neural Precursor Cells Expanded Inside the 3D Micro-Scaffold Nichoid Present Different Non-Coding RNAs Profiles and Transcript Isoforms Expression: Possible Epigenetic Modulation by 3D Growth

Autorzy: Letizia Messa, Bianca Barzaghini, Federica Rey, Cecilia Pandini, Gian Vincenzo Zuccotti, Cristina Cereda, Stephana Carelli Carelli, Manuela Teresa Raimondi
Opublikowane w: Biomedicines, Numer 9, 2025, Strona(/y) 1120, ISSN 2227-9059
Wydawca: MDPI AG
DOI: 10.3390/biomedicines9091120

A Miniaturized Imaging Window to Quantify Intravital Tissue Regeneration within a 3D Microscaffold in Longitudinal Studies

Autorzy: Claudio Conci, Emanuela Jacchetti, Laura Sironi, Lorenzo Gentili, Giulio Cerullo, Roberto Osellame, Giuseppe Chirico, Manuela Teresa Raimondi
Opublikowane w: Advanced Optical Materials, Numer 2101103, 2022, Strona(/y) 1-12, ISSN 2195-1071
Wydawca: Wiley online
DOI: 10.1002/adom.202101103

Proteinaceous microstructure in a capillary: a study of non-linear bending dynamics

Autorzy: Marini, M., Zeynali, A., Collini, M., Bouzin M, Sironi L., D'Alfonso L., Mantegazza F., Cassina, V., Chirico, G.
Opublikowane w: Lab on a chip, Numer 22, 2022, Strona(/y) 4917-4932, ISSN 1473-0197
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2lc00697a

Melanin concentration maps by label-free super-resolution photo-thermal imaging on melanoma biopsies

Autorzy: Margaux Bouzin, Mario Marini, Giuseppe Chirico, Francesca Granucci, Francesca Mingozzi, Roberto Colombo, Laura D’Alfonso, Laura Sironi, Maddalena Collini
Opublikowane w: Biomedical Optics Express, Numer 13, 2024, Strona(/y) 1173, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.445945

Effect of 3D Synthetic Microscaffold Nichoid on the Morphology of Cultured Hippocampal Neurons and Astrocytes

Autorzy: Clara Alice Musi, Luca Colnaghi, Arianna Giani, Erica Cecilia Priori, Giacomo Marchini, Matteo Tironi, Claudio Conci, Giulio Cerullo, Roberto Osellame, Manuela Teresa Raimondi, Andrea Remuzzi, Tiziana Borsello
Opublikowane w: Cells, Numer 11, 2025, Strona(/y) 2008, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells11132008

<i>In vivo</i> label-free tissue histology through a microstructured imaging window

Autorzy: Claudio Conci, Laura Sironi, Emanuela Jacchetti, Davide Panzeri, Donato Inverso, Rebeca Martínez Vázquez, Roberto Osellame, Maddalena Collini, Giulio Cerullo, Giuseppe Chirico, Manuela Teresa Raimondi
Opublikowane w: APL Bioengineering, Numer 8, 2025, Strona(/y) 016102, ISSN 2473-2877
Wydawca: AIP Publishing
DOI: 10.1063/5.0165411

Understanding local immunity to enable regionalized medicine

Autorzy: Marco De Giovanni, Donato Inverso, Matteo Iannacone
Opublikowane w: The EMBO Journal, Numer 43, 2024, Strona(/y) 5788-5792, ISSN 1460-2075
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00255-6

Development of an Oriented Co-Culture System Using 3D Scaffolds Fabricated via Non-Linear Lithography.

Autorzy: Kordas, A., Manganas, P., Selimis, A., Barmparis, G. D., Farsari, M., & Ranella, A.
Opublikowane w: Materials, 2022, Strona(/y) 15(12), ISSN 1996-1944
Wydawca: MDPI Open Access Publishing
DOI: 10.3390/ma15124349

Quantitative active super-resolution thermal imaging: The melanoma case study

Autorzy: Mario Marini, Margaux Bouzin, Riccardo Scodellaro, Laura D’Alfonso, Laura Sironi, Francesca Granucci, Francesca Mingozzi, Giuseppe Chirico, Maddalena Collini
Opublikowane w: Biomolecular Concepts, Numer 13, 2022, Strona(/y) 242-255, ISSN 1868-503X
Wydawca: Walter de Gruyter GmbH
DOI: 10.1515/bmc-2022-0015

3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells

Autorzy: Francesca Donnaloja, Manuela Teresa Raimondi, Letizia Messa, Bianca Barzaghini, Federica Carnevali, Emanuele Colombo, Davide Mazza, Chiara Martinelli, Lucia Boeri, Federica Rey, Cristina Cereda, Roberto Osellame, Giulio Cerullo, Stephana Carelli, Monica Soncini, Emanuela Jacchetti
Opublikowane w: APL Bioengineering, Numer 7, 2025, Strona(/y) 036112, ISSN 2473-2877
Wydawca: AIP Publishing
DOI: 10.1063/5.0153215

Implantable Micro-optics for label-free non-linear imaging

Autorzy: Mario Marini, Davide Panzeri, Alessandra Nardini, Behjat S. Kariman, Claudio Conci, Laura Sironi, Donato Inverso, Emanuela Jacchetti, Rebeca Martinez Vázquez, Roberto Osellame, Maddalena Collini, Giulio Cerullo, Manuela Teresa Raimondi, Elmina Kabouraki, Maria Farsari, Nikos Kehaghias, Konstantina Tourlouki, Giuseppe Chirico
Opublikowane w: EPJ Web of Conferences, Numer 309, 2024, Strona(/y) 04011, ISSN 2100-014X
Wydawca: EDP Sciences
DOI: 10.1051/epjconf/202430904011

Multiphoton laser fabrication of hybrid photo-activable biomaterials

Autorzy: Margaux Bouzin; Amirbahador Zeynali; Mario Marini; Laura Sironi; Riccardo Scodellaro; Laura D'Alfonso; Maddalena Collini; Giuseppe Chirico
Opublikowane w: Sensors (Basel, Switzerland), Numer 1, 2021, ISSN 1424-8220
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21175891

Fabrication of Plano-convex Microlenses using Two-Photon Polymerization for Bioimaging with Non-Linear Excitation Microscopy

Autorzy: Behjat S. Kariman, Alessandra Nardini, Marco Grassi, Mario Marini, Claudio Conci, Margaux Bouzin, Maddalena Collini, Manuela T. Raimondi, Giuseppe Chirico, Roberto Osellame, Giulio Cerullo, Rebeca Martínez Vázquez
Opublikowane w: EPJ Web of Conferences, Numer 287, 2023, Strona(/y) 03009, ISSN 2100-014X
Wydawca: EDP Sciences
DOI: 10.1051/epjconf/202328703009

Engineering macrophage responses through 3D scaffold microarchitecture

Autorzy: Chiara Martinelli, Srijan Chakraborty, Giovanni Buccioli, Matteo Vicini, Claudio Conci, Giulio Cerullo, Roberto Osellame, Giuseppe Chirico, Emanuela Jacchetti, Manuela Teresa Raimondi
Opublikowane w: Materials Today Bio, Numer 35, 2025, Strona(/y) 102328, ISSN 2590-0064
Wydawca: Elsevier BV
DOI: 10.1016/j.mtbio.2025.102328

High dioptric power micro-lenses fabricated by two-photon polymerization

Autorzy: Giuseppe Chirico, Behjat Kariman, Alessandra Nardini, Mario Marini, Pablo Roldan, claudio Conci, Manuela Raimondi, Roberto Osellame, Giulio Cerullo, REBECA MARTINEZ VAZQUEZ
Opublikowane w: Optics Express, Numer Vol. 32, Numer 27, 2024, Strona(/y) 48114-48131, ISSN 1094-4087
Wydawca: Optical Society of America
DOI: 10.1364/opticaopen.27231798.v1

A 3D millifluidic model of a dermal perivascular microenvironment on a chip

Autorzy: Chiara Martinelli, Alberto Bocconi, Sofia Milone, Teresa Baldissera, Leonardo Cherubin, Giovanni Buccioli, Simone Perottoni, Claudio Conci, Giulio Cerullo, Roberto Osellame, Giuseppe Chirico, Emanuela Jacchetti, Manuela Teresa Raimondi
Opublikowane w: Lab on a Chip, Numer 25, 2025, Strona(/y) 423-439, ISSN 1473-0197
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4lc00898g

Microlenses Fabricated by Two-Photon Laser Polymerization for Cell Imaging with Non-Linear Excitation Microscopy.

Autorzy: Marini, M., Nardini, A., Vázquez, R. M., Conci, C., Bouzin, M., Collini, M., Osellame, R., Cerullo, G., Kariman, B. S., Farsari, M., Kabouraki, E., Raimondi, M. T., & Chirico, G.
Opublikowane w: Adv. Funct. Mater., 2023, Strona(/y) 2213926, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202213926

High-resolution lightweight and multifunctional 3D printed scaffolds for cell studies.

Autorzy: Flamourakis, G., Kordas, A., Papageorgiou, M., Pateraki, V., Farsari, M., & Ranella, A.
Opublikowane w: Results in Materials, 2023, ISSN 2590-048X
Wydawca: Elsevier
DOI: 10.1016/j.rinma.2023.100393

Agent-based modeling of macrophage-fibroblast interactions in the immune response to biomaterials

Autorzy: Jennifer Riccio, Luca Presotto, Shir Bahiri, Liad Doniza, Donato Inverso, Laura Sironi, Uri Nevo, Giuseppe Chirico
Opublikowane w: PLOS One, Numer 20, 2025, Strona(/y) e0329186, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0329186

Two-Photon Polymerization Lithography for Optics and Photonics: Fundamentals, Materials, Technologies, and Applications

Autorzy: Wang, H., Zhang, W., Ladika, D., Yu, H., Gailevičius, D., Wang, H., Pan, C. F., Nair, P. N. S., Ke, Y., Mori, T., Chan, J. Y. E., Ruan, Q., Farsari, M., Malinauskas, M., Juodkazis, S., Gu, M., & Yang, J. K. W.
Opublikowane w: Advanced Functional Materials, 2023, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202214211