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Restoring Odorant detection and recognition in Smell dEficits

Project description

Digital technology for olfaction restoration

Partial or total loss of smell (hyposmia/anosmia) affects 20 % of the world population with harmful effects on quality of life. However, while scientists have developed prostheses and implants for other sensory deficits, no devices as yet exist that restore olfactory capacity as scientific knowledge linking artificial systems to human biological olfaction is scarce. The EU-funded Rose project will generate new segments of knowledge to be combined for the construction of a final proof of concept, the Digital Olfaction Module (DOM). DOM will enable people with loss of smell to perceive their olfactory environment. In the domain of sensory prostheses, the project will provide stepwise innovation that was previously unfathomed.

Objective

Sensory deficits are a major source of handicap in people's lives. Scientists have already developed prostheses and implants for hearing impairments and are developing those for vision. Partial and total loss of smell (hyposmia / anosmia) impacts 20% of the world-wide population with deleterious effects on quality of life. However, we have yet to develop such devices to restore the sense of smell, primarily because scientific knowledge linking artificial systems to human biological olfaction is still lacking. Within Rose we envision such a long-term idea. Rose will generate new pieces of scientific knowledge that will be merged to construct a final proof of concept: the Digital Olfaction Module (DOM), a science-to-technology breakthrough enabling people with olfactory loss to perceive their olfactory environment. To this end, Rose will conduct ambitious interdisciplinary research: each partner will be assigned a specific role aligned with their domain of expertise and asked to push conventional boundaries. The Grenoble team (nanotechnology) will develop a new generation of miniaturized odor sensors. The Lausanne team (microtechnology) will develop a stimulation array. The Aryballe team (SME, biotechnology) and the Milano team (design and mechanics) will combine the sensors and the stimulators to design the DOM. The Dresden (neurosurgery), Thessaloniki (clinical olfaction) and Lyon (cognitive neuroscience) teams will test the DOM in humans with smell disorders. To the millions that suffer from hyposmia and anosmia, Rose will provide stepwise innovation previously unfathomed to overcome scientific and societal challenges and industrial competitiveness in the domain of sensory protheses.

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RIA - Research and Innovation action

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(opens in new window) H2020-FETOPEN-2018-2020

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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 435 838,75
Address
RUE MICHEL ANGE 3
75794 PARIS
France

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Region
Ile-de-France Ile-de-France Hauts-de-Seine
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Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 435 838,75

Participants (6)

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