Skip to main content

Redefining mass spectrometry – a breakthrough platform for real-time noninvasive breath analysis with single ion detection of intact viruses and bacteria and post-analysis molecular characterization

Objective

The extraordinary ability of the coronavirus to spread in the environment has established the Covid-19 pandemic as the biggest challenge humanity faces in the XXI century. Covid-19 attacks humans regardless of age, claiming the life of over 8,000 people in a single day, with a devastating death toll exceeding 350,000 in just a few months. The virus is likely to survive for the foreseeable future and disperse further, requiring long-term planning and investment in developing means of detection, protection and cure. Protective measures based on monitoring the dispersion of the coronavirus in the environment and fast screening of individuals has become paramount for ensuring safety of our ageing population and restarting/supporting the worldwide economy. The objective of the ARIADNE project is to develop a multiple-stage analytical platform based on multi-dimensional mass spectrometry instrumentation. Performing direct and instant detection of intact virus particles in breath and in water, and going far beyond that task, this unique analytical platform will push the scientific boundaries in all aspects of analytical sciences centered on mass spectrometry, incorporating a series of potentially disruptive technologies integrated into a single system. ARIADNE integrates state-of-the-art technological advancements in breath sampling and post-ionization methods, new analytical tools for characterization of the protein content of viruses by top-down mass spectrometry, non-destructive ultra-high mass analysis of single particles followed by their soft landing and further processing based on advanced single proteomic workflows. A compact and simplified version of this versatile and powerful analytical platform is also envisaged for advancing the field of real-time breath analytics. Applications extending the analytical capabilities of the system to new viruses, intact bacteria as well as whole human cells will also become accessible.

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

FASMATECH EPISTIMONIKI KAI TECHNOLOGIKI ANONYMI ETAIREIA
Address
Patriarchou Grigoriou E Kai Neapoleos, Lefkippos Technology Park, Ncsr Demokritos, Building 27
153 41 Agia Paraskevi
Greece
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 367 500

Participants (5)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 617 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
FOSSIL ION TECHNOLOGY SL
Spain
EU contribution
€ 495 000
Address
Calle Cipreses 18
28036 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE
Germany
EU contribution
€ 600 000
Address
Martinistrasse 52
20251 Hamburg
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 452 500
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
SPECTROSWISS SARL
Switzerland
EU contribution
€ 450 000
Address
Epfl Innovation Park Building I
1015 Lausanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)