Description du projet
Un nouveau souffle contre le coronavirus
Pour vaincre la propagation du coronavirus, il faut planifier et investir dans le développement de moyens de détection, de protection et de traitement. Des mesures visant à surveiller la dispersion du coronavirus et le dépistage rapide des individus sont indispensables. Il est également urgent de distinguer rapidement la COVID‑19 des autres affections respiratoires. Dans ce contexte, le projet ARIADNE, financé par l’UE, proposera une analyse de l’haleine pour dépister la COVID‑19. Plus précisément, il développe une plateforme analytique à plusieurs étapes basée sur une instrumentation de spectrométrie de masse multidimensionnelle. Elle intégrera les avancées technologiques en matière d’échantillonnage de l’haleine et de méthodes de post‑ionisation. Une version réduite et simplifiée de cette plateforme révolutionnaire sera également développée pour faire progresser le domaine de l’analyse de l’haleine en temps réel.
Objectif
The extraordinary ability of the coronavirus to spread in the environment has established the Covid-19 pandemic as the biggest challenge humanity faces in the XXI century. Covid-19 attacks humans regardless of age, claiming the life of over 8,000 people in a single day, with a devastating death toll exceeding 350,000 in just a few months. The virus is likely to survive for the foreseeable future and disperse further, requiring long-term planning and investment in developing means of detection, protection and cure. Protective measures based on monitoring the dispersion of the coronavirus in the environment and fast screening of individuals has become paramount for ensuring safety of our ageing population and restarting/supporting the worldwide economy. The objective of the ARIADNE project is to develop a multiple-stage analytical platform based on multi-dimensional mass spectrometry instrumentation. Performing direct and instant detection of intact virus particles in breath and in water, and going far beyond that task, this unique analytical platform will push the scientific boundaries in all aspects of analytical sciences centered on mass spectrometry, incorporating a series of potentially disruptive technologies integrated into a single system. ARIADNE integrates state-of-the-art technological advancements in breath sampling and post-ionization methods, new analytical tools for characterization of the protein content of viruses by top-down mass spectrometry, non-destructive ultra-high mass analysis of single particles followed by their soft landing and further processing based on advanced single proteomic workflows. A compact and simplified version of this versatile and powerful analytical platform is also envisaged for advancing the field of real-time breath analytics. Applications extending the analytical capabilities of the system to new viruses, intact bacteria as well as whole human cells will also become accessible.
Champ scientifique
- natural sciencesbiological sciencesmicrobiologybacteriology
- natural sciencesbiological sciencesmicrobiologyvirology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
Mots‑clés
Programme(s)
Régime de financement
RIA - Research and Innovation actionCoordinateur
153 41 AGIA PARASKEVI
Grèce
L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.