Revolutionary Platform to Decipher Immunogenicity of Tumour Neoantigens- the Ultimate Targets for Future Immunotherapies to Eradicate Cancer

Informations projet

DECOD-Ag

N° de convention de subvention: 964998

DOI

10.3030/964998

Date de signature de la CE 8 Mars 2021

Date de début 1 Juin 2021

Date de fin 31 Mai 2026

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 2 999 993,75

Contribution de l’UE

€ 2 999 993,75

Coordonné par

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (4)

Preparation of responder cells

Isolation of responder cells healthy donor T cells HLAmatched to the aAPC line

Plan for communication, dissemination, and exploitation (first release)

Dissemination and communication activities planned and ongoing plan for results exploitation is in place

Project Management Plan

Generation of project management plan covering work plan monitoring quality and communication

Ethical Management Plan

A strategic document describing all the fundamental ethical issues relevant to the project and defining the procedures to be followed by all Consortium partners

Demonstrators, pilots, prototypes (1)

Stable transduction of single HLA alleles into subpools of aAPC produced in 1.2

Generation of a aAPC line expressing mutant peptides and single HLA alleles using existing vectors for common HLA types.

Websites, patent fillings, videos etc. (1)

Website and logo available

Establishment of website and logo

Open Research Data Pilot (1)

Data management plan

Generation of a data management plan containing roles and responsibilities and development of a data model to capture WP outputs

Publications

Peer reviewed articles (2)

Breaking the performance ceiling for neoantigen immunogenicity prediction

Auteurs: Hugh O’Brien, Max Salm, Laura T. Morton, Maciej Szukszto, Felix O’Farrell, Charlotte Boulton, Pablo D. Becker, Yardena Samuels, Charles Swanton, Marc R. Mansour, Sine Reker Hadrup, Sergio A. Quezada
Publié dans: Nature Cancer, Numéro 4, 2024, Page(s) 1618-1621, ISSN 2662-1347
Éditeur: Nature Cancer
DOI: 10.1038/s43018-023-00675-z

A modular protein language modelling approach to immunogenicity prediction

Auteurs: Hugh O’Brien, Max Salm, Laura T. Morton, Maciej Szukszto, Felix O’Farrell, Charlotte Boulton, Laurence King, Supreet Kaur Bola, Pablo D. Becker, Andrew Craig, Morten Nielsen, Yardena Samuels, Charles Swanton, Marc R. Mansour, Sine Reker Hadrup, Sergio A. Quezada
Publié dans: PLOS Computational Biology, Numéro 20, 2024, Page(s) e1012511, ISSN 1553-7358
Éditeur: PLOS Computational Biology
DOI: 10.1371/journal.pcbi.1012511