Revolutionary Platform to Decipher Immunogenicity of Tumour Neoantigens- the Ultimate Targets for Future Immunotherapies to Eradicate Cancer

Informazioni relative al progetto

DECOD-Ag

ID dell’accordo di sovvenzione: 964998

DOI

10.3030/964998

Data della firma CE 8 Marzo 2021

Data di avvio 1 Giugno 2021

Data di completamento 31 Maggio 2026

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 2 999 993,75

Contributo UE

€ 2 999 993,75

Coordinato da

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (4)

Preparation of responder cells

Isolation of responder cells healthy donor T cells HLAmatched to the aAPC line

Plan for communication, dissemination, and exploitation (first release)

Dissemination and communication activities planned and ongoing plan for results exploitation is in place

Project Management Plan

Generation of project management plan covering work plan monitoring quality and communication

Ethical Management Plan

A strategic document describing all the fundamental ethical issues relevant to the project and defining the procedures to be followed by all Consortium partners

Demonstrators, pilots, prototypes (1)

Stable transduction of single HLA alleles into subpools of aAPC produced in 1.2

Generation of a aAPC line expressing mutant peptides and single HLA alleles using existing vectors for common HLA types.

Websites, patent fillings, videos etc. (1)

Website and logo available

Establishment of website and logo

Open Research Data Pilot (1)

Data management plan

Generation of a data management plan containing roles and responsibilities and development of a data model to capture WP outputs

Pubblicazioni

Peer reviewed articles (2)

Breaking the performance ceiling for neoantigen immunogenicity prediction

Autori: Hugh O’Brien, Max Salm, Laura T. Morton, Maciej Szukszto, Felix O’Farrell, Charlotte Boulton, Pablo D. Becker, Yardena Samuels, Charles Swanton, Marc R. Mansour, Sine Reker Hadrup, Sergio A. Quezada
Pubblicato in: Nature Cancer, Numero 4, 2024, Pagina/e 1618-1621, ISSN 2662-1347
Editore: Nature Cancer
DOI: 10.1038/s43018-023-00675-z

A modular protein language modelling approach to immunogenicity prediction

Autori: Hugh O’Brien, Max Salm, Laura T. Morton, Maciej Szukszto, Felix O’Farrell, Charlotte Boulton, Laurence King, Supreet Kaur Bola, Pablo D. Becker, Andrew Craig, Morten Nielsen, Yardena Samuels, Charles Swanton, Marc R. Mansour, Sine Reker Hadrup, Sergio A. Quezada
Pubblicato in: PLOS Computational Biology, Numero 20, 2024, Pagina/e e1012511, ISSN 1553-7358
Editore: PLOS Computational Biology
DOI: 10.1371/journal.pcbi.1012511