Project description
Groundbreaking lab-on-a-chip for cancer diagnosis
Circulating tumour cells (CTCs), carried around the body in the blood circulation, are responsible for cancer metastasis. The EU-funded BIOCELLPHE project proposes the generation of engineered bacteria that can identify and bind to specific protein targets on the surface of CTCs, triggering the production of chemical signals that can be identified with extreme sensitivity using surface-enhanced Raman scattering (SERS). SERS is an analytical technique employing plasmonic nanoparticles as optical enhancers for ultrasensitive chemical analysis at a single-molecule detection level. Researchers will create a lab-on-a-chip SERS device for the ultrasensitive identification and multiplex phenotyping of CTCs. This initiative will pave the way for a new era of medical diagnostics, providing a new paradigm for biology and biomedicine.
Fields of science
- natural sciencescomputer and information sciencesartificial intelligence
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- natural sciencesbiological sciencessynthetic biology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesclinical medicineoncology
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
36310 Vigo Pontevedra
Spain
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Participants (8)
75654 Paris
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75007 Paris Cedex 07
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28006 Madrid
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4715-330 Braga
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27100 Pavia
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28040 Madrid
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4700314 Braga
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
75009 Paris
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.