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Ultrasensitive BIOsensing platform for multiplex CELLular protein PHEnotyping at single-cell level

Objective

BIOCELLPHE provides frontier scientific and technological advancements to generate a breakthrough technology realizing the identification of proteins (i.e. phenotyping) as diagnostic biomarkers at single-cell level with unmatched sensitivity, multiplexing capabilities and portability. BIOCELLPHE proposes the generation of engineered bacteria able to recognize and bind to specific protein targets on the surface of circulating tumor cells (CTCs) responsible for cancer metastasis, thereby triggering the production of chemical signals that can be detected simultaneously, and with extremely high sensitivity by surface-enhanced Raman scattering (SERS). SERS is a powerful analytical technique that employs plasmonic nanoparticles as optical enhancers for ultrasensitive chemical analysis achieving single-molecule detection level. BIOCELLPHE will implement these advancements toward the generation of an optofluidic lab-on-a-chip SERS device enabling ultrasensitive identification and multiplex phenotyping of CTCs. We anticipate that BIOCELLPHE long-term vision and scientific breakthrough will lead to a sky limit technology that will be widely applicable, not only in the diagnostic arena, but also in many other applications (e.g. biomedical, environmental). No one has previously been able to attempt this vision due to current challenges and technical limitations, but we believe to be in a position to pave a way for achieving this now. To realize this highly ambitious project, BIOCELLPHE gathers a highly multidisciplinary community of leading experts in synthetic biology, nanotechnology, plasmonics, microfluidics, artificial intelligence, and cancer diagnosis. We believe that successful deployment of BIOCELLPHE has the potential to usher in a new era of medical diagnostics and it will provide new paradigms in biology and biomedicine, advancing frontier science and technologies at the European academic and industrial sectors.

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
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Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSIDAD DE VIGO
Address
Lg Campus Lagoas Marcosende
36310 Vigo Pontevedra
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 708 000

Participants (8)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 530 375
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 531 875
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 534 187,50
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA
Portugal
EU contribution
€ 448 125
Address
Avenida Mestre Jose Veiga Congredados
4715 330 Braga
Activity type
Research Organisations
ISTITUTI CLINICI SCIENTIFICI MAUGERI SOCIETA' PER AZIONI SOCIETA' BENEFIT
Italy
EU contribution
€ 155 625
Address
Via Salvatore Maugeri 4
27100 Pavia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDAD POLITECNICA DE MADRID
Spain
EU contribution
€ 303 250
Address
Calle Ramiro De Maeztu 7 Edificio Rectorado
28040 Madrid
Activity type
Higher or Secondary Education Establishments
RUBYNANOMED, UNIPESSOAL LDA
Portugal
EU contribution
€ 150 000
Address
Edificio Gnration 123
4700314 Braga
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TEMATYS
France
EU contribution
€ 215 875
Address
6 Cite De Trevise
75009 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)