Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment

Project Information

PLASTICHEAL

Grant agreement ID: 965196

DOI 10.3030/965196

EC signature date 29 January 2021

Start date 1 April 2021

End date 31 March 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 999 571,25

EU contribution € 5 999 571,25

Coordinated by

UNIVERSITAT AUTONOMA DE BARCELONA
Spain

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Report containing the management strategy of the project

Documents, reports (9)

Legal & Ethics Management Handbook

Ethics manual

Protocol of synthesis of reference MNPLs together with their respective characterization

Report containing the datasheets of the reference MNPLs of the project

Communication and Dissemination Plan

Detail of the communication and dissemination action

Joint policy brief 1

The Cluster policy briefs will be defined by the cluster partners

Project Management Handbook

Management strategy of the project

Common dissemination and communication strategy for the cluster

Cluster communication and dissemination plan will take into account projects individual plans shared This report will be updated during clusters life

Cluster brochure
Validated in vitro models to quantify the effect of gastrointestinal digestion on MNPLs bioavailability and toxicity and of associated harmful contaminants and toxic additives

Report related to the in vitro models useful to study MNPLs impact on the GIT

Standard operating procedures for the application of analytical methods to the detection and measurement of MNPLs in biological tissues

SOPs to study MNPLs in tissue samples

Websites, patent fillings, videos etc. (2)

Project website

Project website in full operation

Cluster web portal and visual identity

The Cluster webportal will be updated regularly.

Publications

Conference proceedings (36)

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Author(s): Villacorta A., L. Rubio, M. Alaraby, M. Lopez-Mesas, V. Fuentes-Cebrian, O.H. Moriones, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Oncogenic effects caused by in vitro long-term co-exposure to polystyrene nanoparticles and arsenic

Author(s): Barguilla I, J. Domenech, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 17, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Author(s): Villacorta A., L. Rubio, M. Alaraby, M. Lopez-Mesas, V. Fuentes-Cebrian, O.H. Moriones, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 31, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Modeling human-derived in vitro barriers for environmental toxicology

Author(s): García-Rodríguez, A., Martín Pérez, J., Rubio, L., Banaei, G., Marcos, R., & Hernández, A.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 27, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Drosophila melanogaster as bioindicator of microbiome dysfunction

Author(s): García-Rodríguez, A., Martín Pérez, J., Rocabert, A., Pareres, L., Alaraby, M., Marcos, R., & Hernández, A.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 165, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Stem cells as unique models to study long-term effects triggered by micro- and nanoplastic exposure: a focus on cell transformation and differentiation

Author(s): Barguilla, I., Guyot, B., & Maguer-Satta, V.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 141, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Effects of the in vitro digestive process on the toxicological profile of polystyrene nanoplastics in different human hematopoietic cell lines

Author(s): Vela L., J. Domenech, R. Marcos. A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 20, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Hazard assessment of different-sized polystyrene nanoplastics in a human B-lymphoblastoid cell line

Author(s): Tavakolpournegari, A., Annangi, B., Villacorta, A., Banaei, G., Martin, J., Pastor, S., Marcos, R., & Hernández, A.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 157, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Long-term exposure to PS and PET nanoparticles in human lung cells

Author(s): Gutiérrez J., L. Rubio, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 30, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Polystyrene nanoplastics: Surface- and size-dependent effects on human primary endothelial cells

Author(s): Martín J., A. García, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 27(1), 166, 2023, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society

In vitro cell transforming capacity of different types of nano-plastics

Author(s): Domenech, J., Villacorta, A., Ferrer, J. F., Llorens, R., Marcos, R., Hernández, A., & Catalán, J.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 38, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Can the digestion of polystyrene nanoplastics modulate their toxicological profile? Studies in three different human hematopoietic cell lines -

Author(s): Vela L., A. Villacorta, L. Rubio, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society, 2022, Page(s) 26, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Human white blood cells after ex vivo exposure to polystyrene nanoplastics

Author(s): Ballesteros S., J. Domenech, I. Barguilla, C. Cortés, R. Marcos, , A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue Vol. 25 No. 1 (2021), 2021, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Author(s): A. Villacorta L. Rubio M. Alaraby M. Lopez-Mesas V. Fuentes-Cebrián O. H. Moriones R. Marcos A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 31, Issue Vol. 26 No. 1 (2022), 2022
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Interactions of in-house made polyethylene terephthalate nanoparticles with human hematopoietic cell lines as an improved model for assessing the health risk of nanoplastics

Author(s): Villacorta A., J. Domenech, M. Alaraby, L. Vela, A. Tavakolpournegari, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 21, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Detection and Quantification of Micro(nano)plastics Release from Photolysis of Surgical Masks

Author(s): Guyu Peng, Dusan Materic, Thorsten Reemtsma
Published in: EGU General Assembly 2023, Issue EGU23-4226, 2023
Publisher: EGU
DOI: 10.5194/egusphere-egu23-4226

Preliminary data on the cytotoxic effects of polyethylene terephthalate and polystyrene nanoplastics on Huh-7 hepatocytes

Author(s): Morataya-Reyes M., A. Villacorta, A. Hernández, R. Marcos
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 29, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Understanding the health risks of exposure to micro- & nano-plastics

Author(s): A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 71, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Sub-lethal in vitro effects of nanoplastics (PET and PS) in primary human nasal epithelial cells (HNEpC) –Role of the autophagy

Author(s): B. Annangi J. Gutiérrez A. Villacorta R. Marcos A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 32, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 32, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Long-term effects of PS and PET nanoplastics in lung cell lines

Author(s): J. Gutiérrez L. Rubio B. Guyot I. Barguilla A. Villacorta A. Bodelón R. Marcos A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 164, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Stemness imbalance and oncogenic effects induced by in vitro chronic exposure to PS and PET nanoplastics in breast progenitor cells

Author(s): I. Barguilla, B. Guyot and V. Maguer-Satta
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 24, Issue Vol. 26 No. 1 (2022), 2022
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Deciphering the effects induced by nanoplastics in peripheral blood immune cells

Author(s): Arribas Arranz, J., Cozzuto, L., Ponomarenko, J., Marcos, R., & Hernández, A.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Size-dependent effects of PSNPLs on human hematopoietic cell lines

Author(s): Tavakolpournegari A., S. Pastor, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society, 2022, Page(s) 24, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Lung barrier establishment using Calu-3 cell line as an in vitro model to study the pulmonary effects of micro and nanoplastics

Author(s): Rubio, L., Gutiérrez, J., García-Rodríguez, A., Marcos, R., & Hernández, A.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 173, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Polystyrene nanoparticles as carriers of environmental pollutants and its toxicological assessment on in vitro human intestinal Caco-2 cells

Author(s): Domenech J., C. Cortés , L. Vela, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 16, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

The impact of polystyrene and polyethylene terephthalate nanoplastics on the growth of Staphylococcus aureus,Pseudomonas aeruginosa and M. smegmatis

Author(s): Nadiia Tytarenko, Iris Romero, Alba Hernández, Jose Domínguez, Alicia Lacoma
Published in: The International Journal of Tuberculosis and Lung Disease (IJTLD), Issue VOLUME 26 NUMBER 11 Supplement 1, 2023, Page(s) S499, ISSN 1027-3719
Publisher: The International Union Against Tuberculosis and Lung Disease

Long-term exposure to PS and PET nanoparticles in human lung cells

Author(s): Gutiérrez J., L. Rubio, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 29, Issue 26, 2022, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Potential harmful effects of nanoplastics derived from teabags in an in vitro model of the intestinal barrier

Author(s): Banaei G., A. Villacorta, A. Tavakolpournegari, A. Garcia-Rodriguez, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 23, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Human white blood cells after ex vivo exposure to polystyrene nanoplastics

Author(s): Ballesteros S., J. Domenech, I. Barguilla, C. Cortés, R. Marcos, , A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics

Author(s): Morataya-Reyes, M., Vela, L., Villacorta, A., Venus, T., Pastor, S., Estrela-Lopis, i., Marcos, R., & Hernández, A.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 154, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process

Author(s): I. Barguilla, J. Domenech, S. Ballesteros, L. Rubio. R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 143, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Studying the effects of nanoplastics derived from teabags in an in vitro model of the intestinal epithelium

Author(s): Banaei, G., Villacorta, A., Tavakolpournegari, A., Garcia-Rodriguez, A., Martin, J., Marcos, R., & Hernández, A.
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 158, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Polystyrene nanoplastics: Surface- and size-dependent effects on human primary endothelial cells

Author(s): Martín J., A. García, R. Marcos, A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 33, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Hazard assessment of polystyrene nanoplastics in primary human nasal epithelial cells, focusing on the autophagic effects

Author(s): B. Annangi A. Villacorta M. López-Mesas V. Fuentes-Cebrián R. Marcos A. Hernández
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 178, Issue Vol. 27 No. 1 (2023), 2023
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Preliminary data on the cytotoxic effects of polyethylene terephthalate and polystyrene nanoplastics on Huh-7 hepatocytes

Author(s): Morataya-Reyes M., A. Villacorta, A. Hernández, R. Marcos
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue Vol. 26 No. 1 (2022), 2022
Publisher: Spanish Environmental Mutagenesis and Genomics Society

Stemness imbalance and oncogenic effects induced by in vitro chronic exposure to PS and PET nanoplastics in breast progenitor cells

Author(s): I. Barguilla, B. Guyot and V. Maguer-Satta
Published in: Spanish Journal of Environmental Mutagenesis and Genomics, Issue 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 21, ISSN 2952-1742
Publisher: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Other (7)

Regulatory Relevance of the European Research Cluster to Understand the Health Impacts of Micro- and Nanoplastics (CUSP)

Author(s): Foss Hansen, Steffen
Published in: 2022
Publisher: CUSP
DOI: 10.5281/zenodo.7101443

Size-dependent effects of PSNPLs on a human B-lymphocyte cell line

Author(s): Tavakolpournegari A, B. Annangi, R. Marcos, A. Hernández
Published in: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Issue Poster 16, 2022
Publisher: IDAEA - CSIC

Polystyrene nanoplastics: surface- and size dependent effects on human primary endothelial cells

Author(s): Martín J, A. García-Rodriguez, R. Marcos, A. Hernández
Published in: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Issue Poster 17, 2022
Publisher: IDAEA - CSIC

The potential effects of the in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics (Poster)

Author(s): Vela L., A. Villacorta, T. Venus, S. Pastor, I. Estrela-Lopis, R. Marcos, A. Hernández
Published in: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Issue Poster 20, 2022
Publisher: IDAEA - CSIC

Development of a fluorescent staining protocol of nanoplastics for cell internalization studies

Author(s): López-Mesas M., I.H. Valido, C. Cazorla Ares, V. Fuentes-Cebrian, A. Hernández, F Carrillo-Navarrete
Published in: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Issue Poster 2, 2022
Publisher: IDAEA - CSIC

Deciphering the effects induced by NPLs in peripheral blood immune cells

Author(s): Arribas Arranz J, J. Ponomarenko, R. Marcos, A. Hernández
Published in: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Issue Poster 15, 2022
Publisher: IDAEA - CSIC

Studying the effects of nano plastics derived from teabags in an in vitro model of the intestinal epithelium (Poster)

Author(s): Banaei G, A. Villacorta, A. Tavakolpournegari, A. Garcia-Rodriguez, R. Marcos, A. Hernández
Published in: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Issue Poster 21, 2022
Publisher: IDAEA - CSIC

Peer reviewed articles (31)

Does size matter? A proteomics-informed comparison of the effects of polystyrene beads of different sizes on macrophages

Author(s): Bastien Dalzon, Véronique Collin-Faure, Julie Devcic, Hélène Diemer, Sarah Cianférani, Thierry Rabilloud
Published in: Environmental Science: Nano, Issue 20518161, 2022, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2en00214k

In Vitro Approaches to Determine the Potential Carcinogenic Risk of Environmental Pollutants

Author(s): Irene Barguilla; Veronique Maguer-Satta; Boris Guyot; Susana Pastor; Ricard Marcos; Alba Hernández
Published in: International Journal of Molecular Sciences, Issue 25, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24097851

Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models

Author(s): Busch, Mathias; Brouwer, Hugo; Aalderink, Germaine; Bredeck, Gerrit; Kämpfer, Angela A.M.; Schins, Roel P.F.; Bouwmeester, Hans
Published in: Frontiers in Toxicology, Vol 5 (2023), Issue 33, 2023, ISSN 2673-3080
Publisher: Frontiers Media SA
DOI: 10.3389/ftox.2023.1112212

Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome

Author(s): Malvina, Pizzuto; Pablo, Pelegrin; Jean-Marie, Ruysschaert
Published in: Progress in Lipid Research, Issue 37, 2022, ISSN 0163-7827
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2022.101182

Hazard assessment of ingested polystyrene nanoplastics in <i>Drosophila</i> larvae

Author(s): Mohamed Alaraby; Doaa Abass; Josefa Domenech; Alba Hernández; Ricard Marcos
Published in: Environmental Sciences: Nano, Issue 20518153, 2022, ISSN 2051-8153
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en01199e

NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers

Author(s): Laura Hurtado-Navarro; Diego Angosto-Bazarra; Pablo Pelegrín; Alberto Baroja-Mazo; Santiago Cuevas
Published in: Antioxidants, Issue 36, 2022, ISSN 2076-3921
Publisher: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antiox11050870

The release of polylactic acid nanoplastics (PLA-NPLs) from commercial teabags. Obtention, characterization, and hazard effects of true-to-life PLA-NPLs

Author(s): Gooya Banaei, Alba García-Rodríguez, Alireza Tavakolpournegari, Juan Martín-Pérez, Aliro Villacorta, Ricard Marcos, Alba Hernández
Published in: Journal of Hazardous Materials, Issue Volume 458, 2023, 2023, Page(s) 131899, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2023.131899

Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process

Author(s): Barguilla, Irene; Domenech, Josefa; Ballesteros Ribera, Sandra; Rubio Lorente, Laura; Marcos Dauder, Ricardo; Hernández Bonilla, Alba
Published in: Journal of Hazardous Materials, Issue 03043894, 2022, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2022.129470

Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity

Author(s): Julio García-Villalba; Laura Hurtado-Navarro; Alejandro Peñín-Franch; Cristina Molina-López; Laura Martínez-Alarcón; Diego Angosto-Bazarra; Alberto Baroja-Mazo; Pablo Pelegrin; Pablo Pelegrin
Published in: Frontiers in Immunology, Issue Vol. 13, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.1101/2022.03.04.483019

Long-Term Effects of Polystyrene Nanoplastics in Human Intestinal Caco-2 Cells.

Author(s): Josefa Domenech; Mariana de Britto; Antonia Velázquez; Susana Pastor; Alba Hernández; Ricard Marcos; Constanza Cortés
Published in: Biomolecules, Issue 1, 2021, ISSN 2218-273X
Publisher: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/biom11101442

Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

Author(s): Irene Barguilla; Vicente Candela-Noguera; Patrick Oliver; Balasubramanyam Annangi; Paula Díez; Elena Aznar; Ramón Martínez-Máñez; Ricard Marcos; Alba Hernández; María Dolores Marcos
Published in: International Journal of Molecular Sciences, Vol 24, Iss 22, p 16158 (2023), Issue 23, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242216158

NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy

Author(s): Laura Hurtado-Navarro, Ernesto José Cuenca-Zamora, Lurdes Zamora, Raúl Teruel-Montoya, Pablo Pelegrín, Francisca Ferrer-Marín
Published in: Cell Reports Medicine, Issue Volume 4, ISSUE 12, 101329, December 19, 2023, 2023, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2023.101329

Are bioplastics safe? Hazardous effects of polylactic acid (PLA) nanoplastics in Drosophila

Author(s): Mohamed Alaraby, Doaa Abass, Marinella Farre, Alba Hernández, Ricard Marcos
Published in: Science of The Total Environment, Issue Vol. 919, 2024, Page(s) 170592, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.170592

P2X7 receptor activation impairs antitumour activity of natural killer cells

Author(s): Alberto Baroja-Mazo, Alejandro Peñín-Franch, Fernando Lucas-Ruiz, Carlos de Torre-Minguela, Cristina Alarcón-Vila, Trinidad Hernández-Caselles, Pablo Pelegrín
Published in: British Journal of Pharmacology, Issue 14765381, 2022, ISSN 1476-5381
Publisher: John Wiley & Sons Ltd on behalf of British Pharmacological Society
DOI: 10.1111/bph.15951

Harmful effects of true-to-life nanoplastics derived from PET water bottles in mouse alveolar macrophages

Author(s): Alireza Tavakolpournegari, Aliro Villacorta, Michelle Morataya-Reyes, Jéssica Arribas Arranz, Gooya Banaei, Susana Pastor, Antonia Velázquez, Ricard Marcos, Alba Hernández, Balasubramanyam Annangi
Published in: Environmental Pollution, Issue Vol. 348, 2024, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123823

The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages

Author(s): Brouwer, Hugo; Porbahaie, Mojtaba; Boeren, Sjef; Busch, Mathias; Bouwmeester, Hans
Published in: Particle and Fibre Toxicology, Issue Vol 21, Iss 1, Pp 1-26 (2024), 2024, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.21203/rs.3.rs-3453458/v1

Insights into the potential carcinogenicity of micro- and nano-plastics

Author(s): Domenech, Josefe; Annangi, Balasubramanyam||; Marcos Dauder, Ricardo||; Hernández Bonilla, Alba||; Catalán Rodríguez, Julia||
Published in: Mutation Research/Reviews in Mutation Research, Issue Volume 791, 2023, ISSN 1383-5742
Publisher: Elsevier BV
DOI: 10.1016/j.mrrev.2023.108453

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Author(s): Angosto-Bazarra, D., Molina-López, C. & Pelegrín, P.
Published in: Communications Biology, Issue 23993642, 2022, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-022-03491-w

Polystyrene Nanoplastics as Carriers of Metals. Interactions of Polystyrene Nanoparticles with Silver Nanoparticles and Silver Nitrate, and Their Effects on Human Intestinal Caco-2 Cells

Author(s): Josefa Domenech; Constanza Cortés; Lourdes Vela; Ricard Marcos; Alba Hernández
Published in: Biomolecules, Issue 2218273X, 2021, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom11060859

Can Current Regulations Account for Intentionally Produced Nanoplastics?

Author(s): Fazel Abdolahpur Monikh, Steffen Foss Hansen, Martina G. Vijver, Esther Kentin, Maria Bille Nielsen, Anders Baun, Kristian Syberg, Iseult Lynch, Eugenia Valsami-Jones, and Willie J.G.M. Peijnenburg
Published in: Environmental Science & Technology, Issue 0013936X, 2022, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.2c00965

ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux

Author(s): Fátima Martín-Sánchez; Vincent Compan; Alejandro Peñín-Franch; Ana Tapia-Abellán; Ana I. Gómez; María C. Baños-Gregori; Florian I. Schmidt; Pablo Pelegrin
Published in: Journal of Cell Biology, Issue 222, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202003053

The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics

Author(s): Lourdes Vela; Aliro Villacorta; Tom Venus; Irina Estrela-Lopis; Susana Pastor; Alba García-Rodriguez; Laura Rubio; Ricard Marcos; Alba Hernández
Published in: Environmental Pollution, Issue 329, 2023, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.121656

ASC nanobodies to counteract the consequences of inflammasome activation

Author(s): Pablo Pelegrin; Sahil ADRIOUCH
Published in: EMBO Molecular Medicine, Issue 17574684, 2022, ISSN 1757-4684
Publisher: EMBO Press on behalf of the European Molecular Biology Organization
DOI: 10.15252/emmm.202216087

Effects of true-to-life PET nanoplastics using primary human nasal epithelial cells

Author(s): Balasubramanyam Annangi; Aliro Villacorta; Lourdes Vela; Alireza Tavakolpournegari; Ricard Marcos; Alba Hernández
Published in: Environmental Toxicology and Pharmacology, Issue 100, 2023, Page(s) 104140, ISSN 1382-6689
Publisher: Elsevier BV
DOI: 10.1016/j.etap.2023.104140

Antagonistic in vivo interaction of polystyrene nanoplastics and silver compounds. A study using Drosophila

Author(s): Mohamed Alaraby; Doaa Abass; Aliro Villacorta; Alba Hernández; Ricard Marcos
Published in: Science of The Total Environment, Issue 18791026, 2022, ISSN 1879-1026
Publisher: Elsevier
DOI: 10.1016/j.scitotenv.2022.156923

Nanoplastics and arsenic co-exposures exacerbate oncogenic biomarkers under an in vitro long-term exposure scenario

Author(s): Irene Barguilla; Josefa Domenech; Laura Rubio; Ricard Marcos; Alba Hernández
Published in: International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 2958, Issue 14220067, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.21203/rs.3.rs-1042926/v1

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Author(s): Aliro Villacorta, Laura Rubio, Mohamed Alaraby, Montserrat López-Mesas, Victor Fuentes-Cebrian, Oscar H. Moriones, Ricard Marcos, Alba Hernández*
Published in: Journal of Hazardous Materials, Issue 03043894, 2022, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2022.129593

Validated method for polystyrene nanoplastic separation in aqueous matrices by asymmetric-flow field flow fraction coupled to MALS and UV–Vis detectors

Author(s): Iris H.Valido, Victor Fuentes-Cebrian, Alba Hernández, Manuel Valiente & Montserrat López-Mesas
Published in: Microchimica Acta, Issue Volume 190, article number 285, 2023, ISSN 0026-3672
Publisher: Springer Verlag
DOI: 10.1007/s00604-023-05851-7

NLRP3 and pyroptosis blockers for treating inflammatory diseases

Author(s): Rebecca C.Coll, KateSchroder, PabloPelegrín
Published in: Trends in Pharmacological Sciences, Issue 01656147, 2022, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2022.04.003

Hazard assessment of nanoplastics is driven by their surface-functionalization. Effects in human-derived primary endothelial cells

Author(s): Joan Martín-Pérez, Aliro Villacorta, Gooya Banaei, Michelle Morataya-Reyes, Alireza Tavakolpournegari, Ricard Marcos, Alba Hernández, Alba García-Rodriguez
Published in: Science of The Total Environment, Issue Volume 934, 2024, Page(s) 173236, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.173236

Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila

Author(s): Mohamed Alaraby, Aliro Villacorta, Doaa Abass, Alba Hernández, Ricard Marcos
Published in: Environmental Pollution, Issue Volume 341, 2024, Page(s) 122968, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122968

Book chapters (2)

Dosimetry and Imaging of Micro and Nanoparticles by Means of High Resolution Techniques

Author(s): T. Venus, T. Meyer, C. Zilberfain, J. Böttner, A. Lampen, O. Creutzenberg, M. Niehof, J. Meijer and I. Estrela-Lopis
Published in: Environmental Nanopollutants: Sources, Occurrence, Analysis and Fate, Issue Special Collection: 2022 ebook collection Series: Chemistry in the Environment, 2022, Page(s) pp. 363-388., ISBN 978-1-83916-489-7
Publisher: The Royal Society of Chemistry
DOI: 10.1039/9781839166570-00363

Potential human health effects following exposure to nano- and microplastics, lessons learned from nanomaterials

Author(s): Hugo Brouwer, Femke L. N. van Oijen and Hans Bouwmeester
Published in: Present Knowledge in Food Safety A Risk-Based Approach Through The Food Chain, 2022, ISBN 978-0-12-823154-8
Publisher: Academic Press (Elsevier)
DOI: 10.1016/b978-0-12-819470-6.00014-7

Non-peer reviewed articles (3)

Environmental Pollutants: Micro and Nanoplastics in Immunity and Respiratory Infections

Author(s): Iris Romero-Andrada, Alicia Lacoma, Alba Hernández, José Domínguez
Published in: Archivos de Bronconeumología, Issue Volume 59, Issue 11, 2023, Page(s) 709-711, ISSN 0300-2896
Publisher: Ediciones Doyma S.A.
DOI: 10.1016/j.arbres.2023.07.005

Evaluation of the toxicity, alveolar cell accumulation and clearance of PET and PS nanoplastics in mouse lungs

Author(s): Thomas Loret, Sonja Holme, Aswin Kuttykattil, Aliro Villacorta, Adriana Rodríguez-Garraus, Tom Venus, Irina Irina Estrela-Lopis, Julia Catalán, Ricard Marcos, Alba Hernández, Cyrill Bussy
Published in: Annals of Work Exposures and Health. Abstracts from the 2023 Inhaled Particles and NanOEH conference, Issue Volume 67, Issue Supplement_1, 2023, Page(s) i53–i54, ISSN 2398-7316
Publisher: Oxford University Press
DOI: 10.1093/annweh/wxac087.130

To be or not to be a nanomaterial

Author(s): Steffen Foss Hansen*, Maria Bille Nielsen, Oliver Foss Hessner Hansen, Lauge Peter Westergaard Clausen, Lars Michael Skjolding, Anders Baun, Rickard Arvidsson
Published in: Journal of NanoParticle Research, Issue Volume 24, article number 235, 2022, ISSN 1388-0764
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11051-022-05613-1