Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment

Informations projet

PLASTICHEAL

N° de convention de subvention: 965196

DOI 10.3030/965196

Date de signature de la CE 29 Janvier 2021

Date de début 1 Avril 2021

Date de fin 31 Mars 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total € 5 999 571,25

Contribution de l’UE € 5 999 571,25

Coordonné par

UNIVERSITAT AUTONOMA DE BARCELONA
Spain

Livrables

Open Research Data Pilot (1)

Data Management Plan

Report containing the management strategy of the project

Documents, reports (9)

Legal & Ethics Management Handbook

Ethics manual

Protocol of synthesis of reference MNPLs together with their respective characterization

Report containing the datasheets of the reference MNPLs of the project

Communication and Dissemination Plan

Detail of the communication and dissemination action

Joint policy brief 1

The Cluster policy briefs will be defined by the cluster partners

Project Management Handbook

Management strategy of the project

Common dissemination and communication strategy for the cluster

Cluster communication and dissemination plan will take into account projects individual plans shared This report will be updated during clusters life

Cluster brochure
Validated in vitro models to quantify the effect of gastrointestinal digestion on MNPLs bioavailability and toxicity and of associated harmful contaminants and toxic additives

Report related to the in vitro models useful to study MNPLs impact on the GIT

Standard operating procedures for the application of analytical methods to the detection and measurement of MNPLs in biological tissues

SOPs to study MNPLs in tissue samples

Websites, patent fillings, videos etc. (2)

Project website

Project website in full operation

Cluster web portal and visual identity

The Cluster webportal will be updated regularly.

Publications

Conference proceedings (36)

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Auteurs: Villacorta A., L. Rubio, M. Alaraby, M. Lopez-Mesas, V. Fuentes-Cebrian, O.H. Moriones, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Oncogenic effects caused by in vitro long-term co-exposure to polystyrene nanoparticles and arsenic

Auteurs: Barguilla I, J. Domenech, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 17, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Auteurs: Villacorta A., L. Rubio, M. Alaraby, M. Lopez-Mesas, V. Fuentes-Cebrian, O.H. Moriones, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 31, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Modeling human-derived in vitro barriers for environmental toxicology

Auteurs: García-Rodríguez, A., Martín Pérez, J., Rubio, L., Banaei, G., Marcos, R., & Hernández, A.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 27, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Drosophila melanogaster as bioindicator of microbiome dysfunction

Auteurs: García-Rodríguez, A., Martín Pérez, J., Rocabert, A., Pareres, L., Alaraby, M., Marcos, R., & Hernández, A.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 165, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Stem cells as unique models to study long-term effects triggered by micro- and nanoplastic exposure: a focus on cell transformation and differentiation

Auteurs: Barguilla, I., Guyot, B., & Maguer-Satta, V.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 141, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Effects of the in vitro digestive process on the toxicological profile of polystyrene nanoplastics in different human hematopoietic cell lines

Auteurs: Vela L., J. Domenech, R. Marcos. A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 20, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Hazard assessment of different-sized polystyrene nanoplastics in a human B-lymphoblastoid cell line

Auteurs: Tavakolpournegari, A., Annangi, B., Villacorta, A., Banaei, G., Martin, J., Pastor, S., Marcos, R., & Hernández, A.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 157, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Long-term exposure to PS and PET nanoparticles in human lung cells

Auteurs: Gutiérrez J., L. Rubio, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 30, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Polystyrene nanoplastics: Surface- and size-dependent effects on human primary endothelial cells

Auteurs: Martín J., A. García, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 27(1), 166, 2023, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

In vitro cell transforming capacity of different types of nano-plastics

Auteurs: Domenech, J., Villacorta, A., Ferrer, J. F., Llorens, R., Marcos, R., Hernández, A., & Catalán, J.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 38, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Can the digestion of polystyrene nanoplastics modulate their toxicological profile? Studies in three different human hematopoietic cell lines -

Auteurs: Vela L., A. Villacorta, L. Rubio, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society, 2022, Page(s) 26, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Human white blood cells after ex vivo exposure to polystyrene nanoplastics

Auteurs: Ballesteros S., J. Domenech, I. Barguilla, C. Cortés, R. Marcos, , A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro Vol. 25 No. 1 (2021), 2021, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Auteurs: A. Villacorta L. Rubio M. Alaraby M. Lopez-Mesas V. Fuentes-Cebrián O. H. Moriones R. Marcos A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 31, Numéro Vol. 26 No. 1 (2022), 2022
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Interactions of in-house made polyethylene terephthalate nanoparticles with human hematopoietic cell lines as an improved model for assessing the health risk of nanoplastics

Auteurs: Villacorta A., J. Domenech, M. Alaraby, L. Vela, A. Tavakolpournegari, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 21, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Detection and Quantification of Micro(nano)plastics Release from Photolysis of Surgical Masks

Auteurs: Guyu Peng, Dusan Materic, Thorsten Reemtsma
Publié dans: EGU General Assembly 2023, Numéro EGU23-4226, 2023
Éditeur: EGU
DOI: 10.5194/egusphere-egu23-4226

Preliminary data on the cytotoxic effects of polyethylene terephthalate and polystyrene nanoplastics on Huh-7 hepatocytes

Auteurs: Morataya-Reyes M., A. Villacorta, A. Hernández, R. Marcos
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 29, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Understanding the health risks of exposure to micro- & nano-plastics

Auteurs: A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 71, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Sub-lethal in vitro effects of nanoplastics (PET and PS) in primary human nasal epithelial cells (HNEpC) –Role of the autophagy

Auteurs: B. Annangi J. Gutiérrez A. Villacorta R. Marcos A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 32, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 32, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Long-term effects of PS and PET nanoplastics in lung cell lines

Auteurs: J. Gutiérrez L. Rubio B. Guyot I. Barguilla A. Villacorta A. Bodelón R. Marcos A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 164, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Stemness imbalance and oncogenic effects induced by in vitro chronic exposure to PS and PET nanoplastics in breast progenitor cells

Auteurs: I. Barguilla, B. Guyot and V. Maguer-Satta
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 24, Numéro Vol. 26 No. 1 (2022), 2022
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Deciphering the effects induced by nanoplastics in peripheral blood immune cells

Auteurs: Arribas Arranz, J., Cozzuto, L., Ponomarenko, J., Marcos, R., & Hernández, A.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Size-dependent effects of PSNPLs on human hematopoietic cell lines

Auteurs: Tavakolpournegari A., S. Pastor, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society, 2022, Page(s) 24, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Lung barrier establishment using Calu-3 cell line as an in vitro model to study the pulmonary effects of micro and nanoplastics

Auteurs: Rubio, L., Gutiérrez, J., García-Rodríguez, A., Marcos, R., & Hernández, A.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 173, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Polystyrene nanoparticles as carriers of environmental pollutants and its toxicological assessment on in vitro human intestinal Caco-2 cells

Auteurs: Domenech J., C. Cortés , L. Vela, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2021, Page(s) 16, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

The impact of polystyrene and polyethylene terephthalate nanoplastics on the growth of Staphylococcus aureus,Pseudomonas aeruginosa and M. smegmatis

Auteurs: Nadiia Tytarenko, Iris Romero, Alba Hernández, Jose Domínguez, Alicia Lacoma
Publié dans: The International Journal of Tuberculosis and Lung Disease (IJTLD), Numéro VOLUME 26 NUMBER 11 Supplement 1, 2023, Page(s) S499, ISSN 1027-3719
Éditeur: The International Union Against Tuberculosis and Lung Disease

Long-term exposure to PS and PET nanoparticles in human lung cells

Auteurs: Gutiérrez J., L. Rubio, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 26(1), 29, Numéro 26, 2022, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Potential harmful effects of nanoplastics derived from teabags in an in vitro model of the intestinal barrier

Auteurs: Banaei G., A. Villacorta, A. Tavakolpournegari, A. Garcia-Rodriguez, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 23, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Human white blood cells after ex vivo exposure to polystyrene nanoplastics

Auteurs: Ballesteros S., J. Domenech, I. Barguilla, C. Cortés, R. Marcos, , A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 25 - XXV Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics

Auteurs: Morataya-Reyes, M., Vela, L., Villacorta, A., Venus, T., Pastor, S., Estrela-Lopis, i., Marcos, R., & Hernández, A.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 154, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process

Auteurs: I. Barguilla, J. Domenech, S. Ballesteros, L. Rubio. R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 143, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Studying the effects of nanoplastics derived from teabags in an in vitro model of the intestinal epithelium

Auteurs: Banaei, G., Villacorta, A., Tavakolpournegari, A., Garcia-Rodriguez, A., Martin, J., Marcos, R., & Hernández, A.
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 158, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Polystyrene nanoplastics: Surface- and size-dependent effects on human primary endothelial cells

Auteurs: Martín J., A. García, R. Marcos, A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 33, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Hazard assessment of polystyrene nanoplastics in primary human nasal epithelial cells, focusing on the autophagic effects

Auteurs: B. Annangi A. Villacorta M. López-Mesas V. Fuentes-Cebrián R. Marcos A. Hernández
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, 27(1), 178, Numéro Vol. 27 No. 1 (2023), 2023
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Preliminary data on the cytotoxic effects of polyethylene terephthalate and polystyrene nanoplastics on Huh-7 hepatocytes

Auteurs: Morataya-Reyes M., A. Villacorta, A. Hernández, R. Marcos
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro Vol. 26 No. 1 (2022), 2022
Éditeur: Spanish Environmental Mutagenesis and Genomics Society

Stemness imbalance and oncogenic effects induced by in vitro chronic exposure to PS and PET nanoplastics in breast progenitor cells

Auteurs: I. Barguilla, B. Guyot and V. Maguer-Satta
Publié dans: Spanish Journal of Environmental Mutagenesis and Genomics, Numéro 26 - XXVI Meeting of the Spanish Environmental Mutagenesis and Genomics Society -, 2022, Page(s) 21, ISSN 2952-1742
Éditeur: Spanish Environmental Mutagenesis and Genomics Society (SEMA)

Other (7)

Regulatory Relevance of the European Research Cluster to Understand the Health Impacts of Micro- and Nanoplastics (CUSP)

Auteurs: Foss Hansen, Steffen
Publié dans: 2022
Éditeur: CUSP
DOI: 10.5281/zenodo.7101443

Size-dependent effects of PSNPLs on a human B-lymphocyte cell line

Auteurs: Tavakolpournegari A, B. Annangi, R. Marcos, A. Hernández
Publié dans: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Numéro Poster 16, 2022
Éditeur: IDAEA - CSIC

Polystyrene nanoplastics: surface- and size dependent effects on human primary endothelial cells

Auteurs: Martín J, A. García-Rodriguez, R. Marcos, A. Hernández
Publié dans: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Numéro Poster 17, 2022
Éditeur: IDAEA - CSIC

The potential effects of the in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics (Poster)

Auteurs: Vela L., A. Villacorta, T. Venus, S. Pastor, I. Estrela-Lopis, R. Marcos, A. Hernández
Publié dans: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Numéro Poster 20, 2022
Éditeur: IDAEA - CSIC

Development of a fluorescent staining protocol of nanoplastics for cell internalization studies

Auteurs: López-Mesas M., I.H. Valido, C. Cazorla Ares, V. Fuentes-Cebrian, A. Hernández, F Carrillo-Navarrete
Publié dans: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Numéro Poster 2, 2022
Éditeur: IDAEA - CSIC

Deciphering the effects induced by NPLs in peripheral blood immune cells

Auteurs: Arribas Arranz J, J. Ponomarenko, R. Marcos, A. Hernández
Publié dans: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Numéro Poster 15, 2022
Éditeur: IDAEA - CSIC

Studying the effects of nano plastics derived from teabags in an in vitro model of the intestinal epithelium (Poster)

Auteurs: Banaei G, A. Villacorta, A. Tavakolpournegari, A. Garcia-Rodriguez, R. Marcos, A. Hernández
Publié dans: 2nd Conference on PLASTIC POLLUTION: the Textile Sector, an example towards a sustainable economy (PLASTIC'2022), Numéro Poster 21, 2022
Éditeur: IDAEA - CSIC

Peer reviewed articles (31)

Does size matter? A proteomics-informed comparison of the effects of polystyrene beads of different sizes on macrophages

Auteurs: Bastien Dalzon, Véronique Collin-Faure, Julie Devcic, Hélène Diemer, Sarah Cianférani, Thierry Rabilloud
Publié dans: Environmental Science: Nano, Numéro 20518161, 2022, ISSN 2051-8161
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2en00214k

In Vitro Approaches to Determine the Potential Carcinogenic Risk of Environmental Pollutants

Auteurs: Irene Barguilla; Veronique Maguer-Satta; Boris Guyot; Susana Pastor; Ricard Marcos; Alba Hernández
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24097851

Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models

Auteurs: Busch, Mathias; Brouwer, Hugo; Aalderink, Germaine; Bredeck, Gerrit; Kämpfer, Angela A.M.; Schins, Roel P.F.; Bouwmeester, Hans
Publié dans: Frontiers in Toxicology, Vol 5 (2023), Numéro 33, 2023, ISSN 2673-3080
Éditeur: Frontiers Media SA
DOI: 10.3389/ftox.2023.1112212

Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome

Auteurs: Malvina, Pizzuto; Pablo, Pelegrin; Jean-Marie, Ruysschaert
Publié dans: Progress in Lipid Research, Numéro 37, 2022, ISSN 0163-7827
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2022.101182

Hazard assessment of ingested polystyrene nanoplastics in <i>Drosophila</i> larvae

Auteurs: Mohamed Alaraby; Doaa Abass; Josefa Domenech; Alba Hernández; Ricard Marcos
Publié dans: Environmental Sciences: Nano, Numéro 20518153, 2022, ISSN 2051-8153
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1en01199e

NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers

Auteurs: Laura Hurtado-Navarro; Diego Angosto-Bazarra; Pablo Pelegrín; Alberto Baroja-Mazo; Santiago Cuevas
Publié dans: Antioxidants, Numéro 36, 2022, ISSN 2076-3921
Éditeur: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/antiox11050870

The release of polylactic acid nanoplastics (PLA-NPLs) from commercial teabags. Obtention, characterization, and hazard effects of true-to-life PLA-NPLs

Auteurs: Gooya Banaei, Alba García-Rodríguez, Alireza Tavakolpournegari, Juan Martín-Pérez, Aliro Villacorta, Ricard Marcos, Alba Hernández
Publié dans: Journal of Hazardous Materials, Numéro Volume 458, 2023, 2023, Page(s) 131899, ISSN 0304-3894
Éditeur: Elsevier BV
DOI: 10.1016/j.jhazmat.2023.131899

Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process

Auteurs: Barguilla, Irene; Domenech, Josefa; Ballesteros Ribera, Sandra; Rubio Lorente, Laura; Marcos Dauder, Ricardo; Hernández Bonilla, Alba
Publié dans: Journal of Hazardous Materials, Numéro 03043894, 2022, ISSN 0304-3894
Éditeur: Elsevier BV
DOI: 10.1016/j.jhazmat.2022.129470

Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity

Auteurs: Julio García-Villalba; Laura Hurtado-Navarro; Alejandro Peñín-Franch; Cristina Molina-López; Laura Martínez-Alarcón; Diego Angosto-Bazarra; Alberto Baroja-Mazo; Pablo Pelegrin; Pablo Pelegrin
Publié dans: Frontiers in Immunology, Numéro Vol. 13, 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.1101/2022.03.04.483019

Long-Term Effects of Polystyrene Nanoplastics in Human Intestinal Caco-2 Cells.

Auteurs: Josefa Domenech; Mariana de Britto; Antonia Velázquez; Susana Pastor; Alba Hernández; Ricard Marcos; Constanza Cortés
Publié dans: Biomolecules, Numéro 1, 2021, ISSN 2218-273X
Éditeur: MDPI Multidisciplinary Digital Publishing Institute
DOI: 10.3390/biom11101442

Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

Auteurs: Irene Barguilla; Vicente Candela-Noguera; Patrick Oliver; Balasubramanyam Annangi; Paula Díez; Elena Aznar; Ramón Martínez-Máñez; Ricard Marcos; Alba Hernández; María Dolores Marcos
Publié dans: International Journal of Molecular Sciences, Vol 24, Iss 22, p 16158 (2023), Numéro 23, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242216158

NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy

Auteurs: Laura Hurtado-Navarro, Ernesto José Cuenca-Zamora, Lurdes Zamora, Raúl Teruel-Montoya, Pablo Pelegrín, Francisca Ferrer-Marín
Publié dans: Cell Reports Medicine, Numéro Volume 4, ISSUE 12, 101329, December 19, 2023, 2023, ISSN 2666-3791
Éditeur: Elsevier
DOI: 10.1016/j.xcrm.2023.101329

Are bioplastics safe? Hazardous effects of polylactic acid (PLA) nanoplastics in Drosophila

Auteurs: Mohamed Alaraby, Doaa Abass, Marinella Farre, Alba Hernández, Ricard Marcos
Publié dans: Science of The Total Environment, Numéro Vol. 919, 2024, Page(s) 170592, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.170592

P2X7 receptor activation impairs antitumour activity of natural killer cells

Auteurs: Alberto Baroja-Mazo, Alejandro Peñín-Franch, Fernando Lucas-Ruiz, Carlos de Torre-Minguela, Cristina Alarcón-Vila, Trinidad Hernández-Caselles, Pablo Pelegrín
Publié dans: British Journal of Pharmacology, Numéro 14765381, 2022, ISSN 1476-5381
Éditeur: John Wiley & Sons Ltd on behalf of British Pharmacological Society
DOI: 10.1111/bph.15951

Harmful effects of true-to-life nanoplastics derived from PET water bottles in mouse alveolar macrophages

Auteurs: Alireza Tavakolpournegari, Aliro Villacorta, Michelle Morataya-Reyes, Jéssica Arribas Arranz, Gooya Banaei, Susana Pastor, Antonia Velázquez, Ricard Marcos, Alba Hernández, Balasubramanyam Annangi
Publié dans: Environmental Pollution, Numéro Vol. 348, 2024, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123823

The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages

Auteurs: Brouwer, Hugo; Porbahaie, Mojtaba; Boeren, Sjef; Busch, Mathias; Bouwmeester, Hans
Publié dans: Particle and Fibre Toxicology, Numéro Vol 21, Iss 1, Pp 1-26 (2024), 2024, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.21203/rs.3.rs-3453458/v1

Insights into the potential carcinogenicity of micro- and nano-plastics

Auteurs: Domenech, Josefe; Annangi, Balasubramanyam||; Marcos Dauder, Ricardo||; Hernández Bonilla, Alba||; Catalán Rodríguez, Julia||
Publié dans: Mutation Research/Reviews in Mutation Research, Numéro Volume 791, 2023, ISSN 1383-5742
Éditeur: Elsevier BV
DOI: 10.1016/j.mrrev.2023.108453

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Auteurs: Angosto-Bazarra, D., Molina-López, C. & Pelegrín, P.
Publié dans: Communications Biology, Numéro 23993642, 2022, ISSN 2399-3642
Éditeur: Springer Nature
DOI: 10.1038/s42003-022-03491-w

Polystyrene Nanoplastics as Carriers of Metals. Interactions of Polystyrene Nanoparticles with Silver Nanoparticles and Silver Nitrate, and Their Effects on Human Intestinal Caco-2 Cells

Auteurs: Josefa Domenech; Constanza Cortés; Lourdes Vela; Ricard Marcos; Alba Hernández
Publié dans: Biomolecules, Numéro 2218273X, 2021, ISSN 2218-273X
Éditeur: MDPI
DOI: 10.3390/biom11060859

Can Current Regulations Account for Intentionally Produced Nanoplastics?

Auteurs: Fazel Abdolahpur Monikh, Steffen Foss Hansen, Martina G. Vijver, Esther Kentin, Maria Bille Nielsen, Anders Baun, Kristian Syberg, Iseult Lynch, Eugenia Valsami-Jones, and Willie J.G.M. Peijnenburg
Publié dans: Environmental Science & Technology, Numéro 0013936X, 2022, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.2c00965

ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux

Auteurs: Fátima Martín-Sánchez; Vincent Compan; Alejandro Peñín-Franch; Ana Tapia-Abellán; Ana I. Gómez; María C. Baños-Gregori; Florian I. Schmidt; Pablo Pelegrin
Publié dans: Journal of Cell Biology, Numéro 222, 2023, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.202003053

The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics

Auteurs: Lourdes Vela; Aliro Villacorta; Tom Venus; Irina Estrela-Lopis; Susana Pastor; Alba García-Rodriguez; Laura Rubio; Ricard Marcos; Alba Hernández
Publié dans: Environmental Pollution, Numéro 329, 2023, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.121656

ASC nanobodies to counteract the consequences of inflammasome activation

Auteurs: Pablo Pelegrin; Sahil ADRIOUCH
Publié dans: EMBO Molecular Medicine, Numéro 17574684, 2022, ISSN 1757-4684
Éditeur: EMBO Press on behalf of the European Molecular Biology Organization
DOI: 10.15252/emmm.202216087

Effects of true-to-life PET nanoplastics using primary human nasal epithelial cells

Auteurs: Balasubramanyam Annangi; Aliro Villacorta; Lourdes Vela; Alireza Tavakolpournegari; Ricard Marcos; Alba Hernández
Publié dans: Environmental Toxicology and Pharmacology, Numéro 100, 2023, Page(s) 104140, ISSN 1382-6689
Éditeur: Elsevier BV
DOI: 10.1016/j.etap.2023.104140

Antagonistic in vivo interaction of polystyrene nanoplastics and silver compounds. A study using Drosophila

Auteurs: Mohamed Alaraby; Doaa Abass; Aliro Villacorta; Alba Hernández; Ricard Marcos
Publié dans: Science of The Total Environment, Numéro 18791026, 2022, ISSN 1879-1026
Éditeur: Elsevier
DOI: 10.1016/j.scitotenv.2022.156923

Nanoplastics and arsenic co-exposures exacerbate oncogenic biomarkers under an in vitro long-term exposure scenario

Auteurs: Irene Barguilla; Josefa Domenech; Laura Rubio; Ricard Marcos; Alba Hernández
Publié dans: International Journal of Molecular Sciences; Volume 23; Numéro 6; Pages: 2958, Numéro 14220067, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.21203/rs.3.rs-1042926/v1

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

Auteurs: Aliro Villacorta, Laura Rubio, Mohamed Alaraby, Montserrat López-Mesas, Victor Fuentes-Cebrian, Oscar H. Moriones, Ricard Marcos, Alba Hernández*
Publié dans: Journal of Hazardous Materials, Numéro 03043894, 2022, ISSN 0304-3894
Éditeur: Elsevier BV
DOI: 10.1016/j.jhazmat.2022.129593

Validated method for polystyrene nanoplastic separation in aqueous matrices by asymmetric-flow field flow fraction coupled to MALS and UV–Vis detectors

Auteurs: Iris H.Valido, Victor Fuentes-Cebrian, Alba Hernández, Manuel Valiente & Montserrat López-Mesas
Publié dans: Microchimica Acta, Numéro Volume 190, article number 285, 2023, ISSN 0026-3672
Éditeur: Springer Verlag
DOI: 10.1007/s00604-023-05851-7

NLRP3 and pyroptosis blockers for treating inflammatory diseases

Auteurs: Rebecca C.Coll, KateSchroder, PabloPelegrín
Publié dans: Trends in Pharmacological Sciences, Numéro 01656147, 2022, ISSN 0165-6147
Éditeur: Elsevier BV
DOI: 10.1016/j.tips.2022.04.003

Hazard assessment of nanoplastics is driven by their surface-functionalization. Effects in human-derived primary endothelial cells

Auteurs: Joan Martín-Pérez, Aliro Villacorta, Gooya Banaei, Michelle Morataya-Reyes, Alireza Tavakolpournegari, Ricard Marcos, Alba Hernández, Alba García-Rodriguez
Publié dans: Science of The Total Environment, Numéro Volume 934, 2024, Page(s) 173236, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.173236

Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila

Auteurs: Mohamed Alaraby, Aliro Villacorta, Doaa Abass, Alba Hernández, Ricard Marcos
Publié dans: Environmental Pollution, Numéro Volume 341, 2024, Page(s) 122968, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122968

Book chapters (2)

Dosimetry and Imaging of Micro and Nanoparticles by Means of High Resolution Techniques

Auteurs: T. Venus, T. Meyer, C. Zilberfain, J. Böttner, A. Lampen, O. Creutzenberg, M. Niehof, J. Meijer and I. Estrela-Lopis
Publié dans: Environmental Nanopollutants: Sources, Occurrence, Analysis and Fate, Numéro Special Collection: 2022 ebook collection Series: Chemistry in the Environment, 2022, Page(s) pp. 363-388., ISBN 978-1-83916-489-7
Éditeur: The Royal Society of Chemistry
DOI: 10.1039/9781839166570-00363

Potential human health effects following exposure to nano- and microplastics, lessons learned from nanomaterials

Auteurs: Hugo Brouwer, Femke L. N. van Oijen and Hans Bouwmeester
Publié dans: Present Knowledge in Food Safety A Risk-Based Approach Through The Food Chain, 2022, ISBN 978-0-12-823154-8
Éditeur: Academic Press (Elsevier)
DOI: 10.1016/b978-0-12-819470-6.00014-7

Non-peer reviewed articles (3)

Environmental Pollutants: Micro and Nanoplastics in Immunity and Respiratory Infections

Auteurs: Iris Romero-Andrada, Alicia Lacoma, Alba Hernández, José Domínguez
Publié dans: Archivos de Bronconeumología, Numéro Volume 59, Numéro 11, 2023, Page(s) 709-711, ISSN 0300-2896
Éditeur: Ediciones Doyma S.A.
DOI: 10.1016/j.arbres.2023.07.005

Evaluation of the toxicity, alveolar cell accumulation and clearance of PET and PS nanoplastics in mouse lungs

Auteurs: Thomas Loret, Sonja Holme, Aswin Kuttykattil, Aliro Villacorta, Adriana Rodríguez-Garraus, Tom Venus, Irina Irina Estrela-Lopis, Julia Catalán, Ricard Marcos, Alba Hernández, Cyrill Bussy
Publié dans: Annals of Work Exposures and Health. Abstracts from the 2023 Inhaled Particles and NanOEH conference, Numéro Volume 67, Numéro Supplement_1, 2023, Page(s) i53–i54, ISSN 2398-7316
Éditeur: Oxford University Press
DOI: 10.1093/annweh/wxac087.130

To be or not to be a nanomaterial

Auteurs: Steffen Foss Hansen*, Maria Bille Nielsen, Oliver Foss Hessner Hansen, Lauge Peter Westergaard Clausen, Lars Michael Skjolding, Anders Baun, Rickard Arvidsson
Publié dans: Journal of NanoParticle Research, Numéro Volume 24, article number 235, 2022, ISSN 1388-0764
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s11051-022-05613-1